Treprostinil
證據等級: L5 | 預測適應症: 10 個
## 藥師評估報告
Treprostinil：從肺動脈高壓到相關併發症
一句話總結
Treprostinil (勵脈展素) 原本用於治療特發性或遺傳性肺動脈高壓。 TxGNN 模型預測它可能對**多種肺動脈高壓相關疾病**有效， 其中**結締組織疾病相關肺動脈高壓**有最強的臨床證據支持。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 特發性或遺傳性肺動脈高壓 (WHO functional class III/IV) |
| 預測新適應症 | pulmonary arteriovenous malformation (disease)、pulmonary arterial hypertension、pulmonary arterial hypertension associated with congenital heart disease、pulmonary arterial hypertension associated with HIV infection、pulmonary arterial hypertension associated with chronic hemolytic anemia、pulmonary arterial hypertension associated with connective tissue disease、pulmonary arterial hypertension associated with schistosomiasis、hypotrichosis simplex of the scalp、congenital hypotrichosis milia、malformation syndrome with odontal and/or periodontal component |
| TxGNN 最高預測分數 | 99.70% (肺動靜脈畸形) |
| 證據等級 | L2 (結締組織疾病相關 PAH) |
| 台灣上市 | 已上市 |
| 許可證數 | 25 張 |
| 建議決策 | Proceed with Guardrails |
預測新適應症一覽
| 疾病名稱 | TxGNN 分數 | 臨床試驗 | 文獻數 |
|---|---|---|---|
| 肺動靜脈畸形 | 99.70% | 0 | 0 |
| 先天性心臟病相關 PAH | 99.60% | 2 | 20+ |
| HIV 感染相關 PAH | 99.55% | 1 | 5 |
| 結締組織疾病相關 PAH | 99.55% | 2 | 20+ |
| 慢性溶血性貧血相關 PAH | 99.55% | 0 | 0 |
| 血吸蟲病相關 PAH | 99.55% | 0 | 0 |
預測適應症詳細分析
1. pulmonary arteriovenous malformation (disease) L5 99.70% 主要分析
2. pulmonary arterial hypertension associated with congenital heart disease L3 99.60%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01383083 | N/A | UNKNOWN | 42 | Effects of Iloprost Treatment in Adult Patients With Pulmonary Arterial Hyperten... |
| NCT02261883 | PHASE2 | TERMINATED | 42 | Intravenous Remodulin (Treprostinil) as Add-on Therapy for the Treatment of Pers... |
相關文獻（19 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35412560 | 2022 | Article | JAMA | Diagnosis and Treatment of Pulmonary Arterial Hypertension: A Review. |
| 29436381 | 2018 | Article | Heart (British Cardiac Society | Subcutaneous treprostinil in congenital heart disease-related pulmonary arterial... |
| 21852894 | 2009 | Article | Progress in pediatric cardiolo | Non-congenital heart disease associated pediatric pulmonary arterial hypertensio... |
| 16919006 | 2006 | Article | European journal of clinical i | Current treatment options in children with pulmonary arterial hypertension and e... |
| 16725066 | 2006 | Article | Cardiology in the young | Bosentan for the treatment of pulmonary arterial hypertension associated with co... |
| 36983605 | 2023 | Article | Journal of personalized medici | Patient Satisfaction with a Dedicated Infusion Pump for Subcutaneous Treprostini... |
| 23890862 | 2013 | Article | International journal of cardi | Long-term effects of continuous prostacyclin therapy in adults with pulmonary hy... |
| 22621693 | 2012 | Article | Drugs | Treatment of pulmonary arterial hypertension in connective tissue disease. |
| 28643420 | 2017 | Article | Cardiovascular therapeutics | Impact on survival of warfarin in patients with pulmonary arterial hypertension ... |
| 35000655 | 2022 | Article | Cardiology in the young | Clinical impact of subcutaneous treprostinil in trisomy 21 patient with pulmonar... |
| 18473715 | 2008 | Article | Expert opinion on pharmacother | Treprostinil for the treatment of pulmonary hypertension. |
| 37892005 | 2023 | Article | Diagnostics (Basel, Switzerlan | Rapidly Progressive Idiopathic Pulmonary Arterial Hypertension in a Paediatric P... |
| 18022071 | 2007 | Article | The Journal of heart and lung | Safety and efficacy of transition from subcutaneous treprostinil to oral sildena... |
| 22872790 | 2012 | Article | Clinical medicine insights. Ci | Clinical utility of treprostinil and its overall place in the treatment of pulmo... |
| 31738929 | 2020 | Article | Chest | Results of an Expert Consensus Survey on the Treatment of Pulmonary Arterial Hyp... |
| 36204579 | 2022 | Article | Frontiers in cardiovascular me | Selexipag-based triple combination therapy improves prognosis in Chinese pulmona... |
| 16098438 | 2005 | Article | Journal of the American Colleg | Effects of long-term bosentan in children with pulmonary arterial hypertension. |
| 21029834 | 2010 | Article | The American journal of cardio | Long-term outcomes in children with pulmonary arterial hypertension treated with... |
| 34925762 | 2021 | Article | Pulmonary circulation | Vasodilator therapy for pulmonary hypertension in children: a national study of ... |
3. pulmonary arterial hypertension associated with HIV infection L2 99.55%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00494533 | PHASE4 | TERMINATED | 45 | Treprostinil for Untreated Symptomatic PAH Trial: A 12-Week Multicenter Randomiz... |
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 14720012 | 2003 | Article | American journal of respirator | Prostanoids for pulmonary arterial hypertension. |
| 18473715 | 2008 | Article | Expert opinion on pharmacother | Treprostinil for the treatment of pulmonary hypertension. |
| 18260882 | 2007 | Article | Kardiologiia | [Pulmonary hypertension and right ventricular failure. Part X. Prostanoids in th... |
4. pulmonary arterial hypertension associated with chronic hemolytic anemia L5 99.55%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
5. pulmonary arterial hypertension associated with connective tissue disease L3 99.55%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT02663895 | PHASE2 | COMPLETED | 12 | A Pilot Study to Evaluate the Safety and Efficacy of Oral Treprostinil in the Tr... |
相關文獻（19 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35412560 | 2022 | Article | JAMA | Diagnosis and Treatment of Pulmonary Arterial Hypertension: A Review. |
| 38378970 | 2024 | Article | Internal and emergency medicin | Treatment of pulmonary arterial hypertension in patients with connective tissue ... |
| 11897647 | 2002 | Article | American journal of respirator | Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in pa... |
| 37765060 | 2023 | Article | Pharmaceuticals (Basel, Switze | Recent Advances in the Treatment of Pulmonary Arterial Hypertension Associated w... |
| 40566626 | 2025 | Article | Life (Basel, Switzerland) | Efficacy and Safety of Selexipag Treatment in Connective Tissue Disease-Associat... |
| 16218473 | 2005 | Article | Lupus | Pulmonary arterial hypertension associated to connective tissue diseases. |
| 22621693 | 2012 | Article | Drugs | Treatment of pulmonary arterial hypertension in connective tissue disease. |
| 15302727 | 2004 | Article | Chest | Treprostinil, a prostacyclin analogue, in pulmonary arterial hypertension associ... |
| 41594679 | 2026 | Article | Biomolecules | Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: Current Th... |
| 34462153 | 2021 | Article | La Revue de medecine interne | [Characteristics of patients with connective tissue disease-associated pulmonary... |
| 11936539 | 2002 | Article | The European respiratory journ | Pulmonary hypertension in collagen vascular disease. |
| 22291467 | 2012 | Article | Drug design, development and t | Inhaled treprostinil: a therapeutic review. |
| 37677880 | 2023 | Article | The American journal of cardio | Transition from Intravenous Epoprostenol to Treprostinil Due to Intolerable Side... |
| 16725066 | 2006 | Article | Cardiology in the young | Bosentan for the treatment of pulmonary arterial hypertension associated with co... |
| 18473715 | 2008 | Article | Expert opinion on pharmacother | Treprostinil for the treatment of pulmonary hypertension. |
| 24387049 | 2014 | Article | Expert opinion on drug safety | Current therapies for the treatment of systemic sclerosis-related pulmonary arte... |
| 18022071 | 2007 | Article | The Journal of heart and lung | Safety and efficacy of transition from subcutaneous treprostinil to oral sildena... |
| 22872790 | 2012 | Article | Clinical medicine insights. Ci | Clinical utility of treprostinil and its overall place in the treatment of pulmo... |
| 31738929 | 2020 | Article | Chest | Results of an Expert Consensus Survey on the Treatment of Pulmonary Arterial Hyp... |
6. pulmonary arterial hypertension associated with schistosomiasis L5 99.55%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
7. hypotrichosis simplex of the scalp L5 99.48%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
8. congenital hypotrichosis milia L5 99.30%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
9. malformation syndrome with odontal and/or periodontal component L4 99.21%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35688447 | 2022 | Article | Journal of clinical periodonto | Treatment of stage IV periodontitis: The EFP S3 level clinical practice guidelin... |
| 37435999 | 2023 | Article | Periodontology 2000 | Complications and treatment errors related to regenerative periodontal surgery. |
| 35420698 | 2022 | Article | The Cochrane database of syste | Treatment of periodontitis for glycaemic control in people with diabetes mellitu... |
| 9495612 | 1998 | Article | Journal of clinical periodonto | Microbial complexes in subgingival plaque. |
| 22057194 | 2012 | Article | Diabetologia | Periodontitis and diabetes: a two-way relationship. |
| 37452425 | 2023 | Article | Advanced science (Weinheim, Ba | Melatonin Engineering M2 Macrophage-Derived Exosomes Mediate Endoplasmic Reticul... |
| 36883660 | 2023 | Article | Journal of dental research | The Role of Gingival Fibroblasts in the Pathogenesis of Periodontitis. |
| 39233377 | 2024 | Article | Periodontology 2000 | Sleep and periodontal health. |
| 29193334 | 2018 | Article | Periodontology 2000 | Comparison of peri-implant and periodontal marginal soft tissues in health and d... |
| 38362600 | 2024 | Article | Journal of dental research | Effect of Periodontitis and Periodontal Therapy on Oral and Gut Microbiota. |
| 29194794 | 2018 | Article | Periodontology 2000 | The periodontal pocket. |
| 7782979 | 1995 | Article | Journal of periodontology | The modified papilla preservation technique. A new surgical approach for interpr... |
| 38907216 | 2024 | Article | Journal of nanobiotechnology | A new direction in periodontitis treatment: biomaterial-mediated macrophage immu... |
| 12010523 | 2002 | Article | Journal of clinical periodonto | Clinical significance of non-surgical periodontal therapy: an evidence-based per... |
| 17243998 | 2007 | Article | Journal of clinical periodonto | A minimally invasive surgical technique with an enamel matrix derivative in the ... |
| 29291254 | 2018 | Article | The Cochrane database of syste | Supportive periodontal therapy (SPT) for maintaining the dentition in adults tre... |
| 34269040 | 2021 | Article | Quintessence international (Be | The apically incised coronally advanced surgical technique (AICAST) for periodon... |
| 27861820 | 2017 | Article | International dental journal | Periodontal disease and the metabolic syndrome. |
| 20599785 | 2010 | Article | Biochemical pharmacology | Complement and periodontitis. |
| 3533789 | 1986 | Article | International dental journal | Juvenile periodontitis. |
10. Ambras type hypertrichosis universalis congenita L5 99.17%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
台灣上市資訊
| 許可證號 | 品名 | 劑型 | 核准適應症 |
|---|---|---|---|
| 衛部罕藥輸字第000071號 | 勵脈展素注射劑1毫克/毫升 | 注射劑 | 特發性或遺傳性肺動脈高壓 (WHO class III/IV) |
| 衛部罕藥輸字第000072號 | 勵脈展素注射劑2.5毫克/毫升 | 注射劑 | 特發性或遺傳性肺動脈高壓 (WHO class III/IV) |
| 衛部罕藥輸字第000074號 | 勵脈展素注射劑10毫克/毫升 | 注射劑 | 特發性或遺傳性肺動脈高壓 (WHO class III/IV) |
| 衛部罕藥輸字第000096號 | 泰肺舒口腔吸入液 | 口腔吸入劑 | 特發性或遺傳性肺動脈高壓 (NYHA class III) |
| 衛部藥輸字第029038號 | 拓肺鬆口腔吸入液 | 口腔吸入劑 | 間質性肺病造成的肺高壓 |
安全性考量
- 給藥途徑：皮下注射可能引起注射部位疼痛及反應
- 血壓影響：可能引起低血壓
- 出血風險：抗血小板作用可能增加出血風險
- 主要交互作用 (Moderate)：
- Acetylsalicylic acid（增加出血風險）
- SGLT2 抑制劑（Canagliflozin、Dapagliflozin、Empagliflozin）
- Epinephrine（可能影響血壓調節）
藥物-疾病注意事項 (DDSI)
資料來源：DDInter 2.0（原文內容請參閱該網站）
Hemorrhage 🟡 Moderate
- 需定期監測。風險包括：出血。
Diverticulum 🟡 Moderate
- 注意事項：The tablet shell of the manufactured form of treprostinil, Orenitram does not dissolve and can lodge in the diverticulum of patients with diverticulos…
低血壓 🟡 Moderate
- 風險包括：低血壓。
肝臟疾病 🟡 Moderate
- 需密切監測。可能有嚴重不良反應。
Pneumonia 🟡 Moderate
- 需定期監測。風險包括：感染。
腎臟疾病 🟡 Moderate
- 通常無需調整劑量。
Hepatic Insufficiency 🟢 Minor
- 本藥物在此情況下禁用。可能有嚴重不良反應。
結論與下一步
決策：Proceed with Guardrails
理由： Treprostinil 在結締組織疾病相關肺動脈高壓中已有充分的臨床證據支持，歐洲治療指南已將其列為 I-B 等級推薦。對於其他預測的適應症（如先天性心臟病相關 PAH），也有臨床試驗和文獻支持。
若要推進需要：
- 針對特定亞型（如 HIV 相關 PAH）的進一步研究
- 吸入式劑型在不同 PAH 亞型中的療效評估
- 與其他 PAH 治療藥物的比較研究
相關藥物報告
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引用本報告
如需引用本報告，請使用以下格式：
APA 格式：
TwTxGNN. (2026). Treprostinil老藥新用驗證報告. https://twtxgnn.yao.care/drugs/treprostinil/
BibTeX 格式：
@misc{twtxgnn_treprostinil,
title = {Treprostinil老藥新用驗證報告},
author = {TwTxGNN Team},
year = {2026},
url = {https://twtxgnn.yao.care/drugs/treprostinil/}
}
免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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