Magnesium Sulfate
證據等級: L5 | 預測適應症: 10 個
## 藥師評估報告
Magnesium Sulfate (硫酸鎂) - 藥師筆記
一句話總結
Magnesium sulfate 為多用途藥物，TxGNN 預測其用於子癇前症/子癇症的預測與台灣現行核准適應症完全一致，具有極豐富的 RCT 及 Phase 3/4 臨床試驗證據，為最高證據等級 (L1)。
快速總覽
| 項目 | 內容 |
|---|---|
| 藥物名稱 | Magnesium Sulfate (硫酸鎂) |
| DrugBank ID | DB00653 |
| 台灣商品名 | 硫酸鎂、濟生硫酸鎂注射液等 |
| 原核准適應症 | 子癇症、子癇前症、妊娠毒血症、抗痙攣、電解質補充、瀉劑 |
| 預測適應症 | 子癇前症/子癇症 (preeclampsia/eclampsia) |
| TxGNN 預測分數 | 0.99999 (極高) |
| TxGNN 排名 | 60 |
| 證據等級 | L1 (多個 RCT 及 Phase 3/4 臨床試驗) |
| 臨床試驗 | 30+ 項相關臨床試驗 |
| PubMed 文獻 | 極豐富 |
預測適應症詳細分析
1. preeclampsia/eclampsia L1 100.00% 主要分析
為什麼這個預測合理？
### 機轉推論
- 中樞神經保護作用：
- Magnesium sulfate 可阻斷 NMDA 受體，減少興奮性神經傳導
- 降低腦血管痙攣及腦灌流壓
- 有效預防子癇症痙攣發作
- 血管擴張效應：
- 作為鈣離子拮抗劑，可放鬆血管平滑肌
- 減少周邊血管阻力
- 改善子宮胎盤血流
- 神經肌肉阻斷：
- 減少乙醯膽鹼釋放
- 降低神經肌肉接合處興奮性
- 預防痙攣性抽搐
- 抗發炎作用：
- 減少促發炎細胞激素釋放
- 保護內皮細胞功能
臨床試驗
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00004399 | NA | COMPLETED | 2000 | Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Ecl... |
| NCT01030627 | PHASE4 | COMPLETED | 85 | Treatment Approaches to Preeclampsia |
| NCT02396030 | PHASE4 | TERMINATED | 62 | Effectiveness and Safety of 1g/Hour vs. 2g/Hour of Magnesium Sulfate Maintenance... |
| NCT03210350 | N/A | COMPLETED | 30 | Effect of Magnesium Sulphate on the Intracranial Pressure of Preeclamptic Patien... |
| NCT05789381 | NA | WITHDRAWN | 0 | Patient Satisfaction and Abbreviated Postpartum Magnesium Sulfate for Preeclamps... |
| NCT04586348 | PHASE4 | ACTIVE_NOT_RECRUITING | 794 | Prenatal Iodine Supplementation and Early Childhood Neurodevelopment |
| NCT02647268 | NA | COMPLETED | 26 | Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in D... |
| NCT00344058 | NA | COMPLETED | 200 | Abbreviated Post-partum Magnesium Sulfate Seizure Prophylaxis in Preeclampsia: A... |
| NCT03549767 | NA | UNKNOWN | 241 | Randomized Trial to Compare Magnesium Sulphate Administration for Preeclampsia a... |
| NCT02317146 | PHASE2, PHASE3 | COMPLETED | 280 | A Novel Protocol for Postpartum Magnesium Sulfate in Severe Preeclampsia When th... |
| NCT01911494 | NA | COMPLETED | 87500 | The CLIP (Community Level Interventions for Pre-eclampsia) Cluster Randomized Co... |
| NCT02307201 | PHASE2, PHASE3 | COMPLETED | 1114 | Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia Receiv... |
| NCT04645719 | PHASE3 | UNKNOWN | 75 | Best Dose of Magnesium Sulfate Infusion in Obese. A Blind and Randomized Trial |
| NCT03318211 | PHASE4 | UNKNOWN | 100 | Continuation Versus Discontinuation of Magnesium Sulfate After Delivery in Women... |
| NCT06126068 | NA | COMPLETED | 120 | Comparison of Loading Dose Magnesium Sulphate With Prichard Regimen in the Manag... |
| NCT02091401 | PHASE4 | COMPLETED | 200 | A Randomized Open-label Study to Compare the Clinical Outcomes and Magnesium Ser... |
| NCT07220902 | PHASE3 | NOT_YET_RECRUITING | 1240 | Levetiracetam Compared to Magnesium Sulfate for Prevention of Eclamptic Seizure:... |
| NCT01360060 | N/A | COMPLETED | 503 | Analgesia After Cesarean Section |
| NCT03412552 | N/A | COMPLETED | 1238 | Risk Analysis of Intensive Care Management on Maternal and Fetal Outcome of Seve... |
| NCT04003688 | NA | COMPLETED | 74 | Strategy to Calculate Magnesium Sulfate Dose in Obese Patients. A Randomized and... |
| NCT06306040 | PHASE3 | NOT_YET_RECRUITING | 105 | Effect of Intravenous Nalbuphine Versus Magnesium Sulfate on Emergence Agitation... |
| NCT01801410 | PHASE3 | COMPLETED | 602 | Induction of Labour in Pre-eclamptic Women: a Randomised Trial Comparing the Fol... |
| NCT00293735 | PHASE2, PHASE3 | WITHDRAWN | 0 | Labetalol Versus MgSO4 for the Prevention of Eclampsia Trial (LAMPET) |
| NCT03237819 | PHASE3 | UNKNOWN | 74 | Interest of Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensiv... |
| NCT05610774 | NA | COMPLETED | 50 | Using Optic Nerve Sheath Diameter to Monitor Intracranial Tension in Pre-Eclampt... |
| NCT01408979 | PHASE4 | COMPLETED | 120 | Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsi... |
| NCT06563908 | NA | NOT_YET_RECRUITING | 784 | Lipiodol® For Enhancing Live Birth Rates In Infertile Couples Undergoing In Vitr... |
| NCT00666133 | NA | COMPLETED | 304 | Treatment Approaches for Preeclampsia in Low-Resource Settings |
| NCT04387565 | N/A | COMPLETED | 210 | Analysis of Maternal Plasma/Urine/Hair Magnesium and Vanadium Levels in Preeclam... |
| NCT04474704 | NA | COMPLETED | 53 | Use of Cheetah® Non-invasive Cardiac Monitoring System to Guide Discontinuation ... |
| NCT05283473 | N/A | COMPLETED | 64 | Serum Concentration of Magnesium Attained in Magnesium Sulfate Therapy in Pregna... |
| NCT01846156 | PHASE3 | COMPLETED | 240 | The Best Magnesium Sulphate Protocol for Severe Pre-eclampsia : A Randomized Con... |
| NCT03891498 | NA | UNKNOWN | 100 | The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal... |
| NCT04501289 | NA | COMPLETED | 114 | Low Dose Magnesium Sulphate Versus Standard Pritchard Regimen In Management Of S... |
| NCT01972659 | PHASE4 | COMPLETED | 80 | Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Block... |
| NCT04300985 | PHASE3 | COMPLETED | 90 | Magnesium Sulfate Versus Dexmedetomidine on Anesthesia Awakening. Randomized Cli... |
| NCT05558969 | NA | COMPLETED | 30 | The Effect of Prophylactic Magnesium Use in Pregnant Women on Reversal of Neurom... |
| NCT06791668 | N/A | RECRUITING | 400 | Comparison of Different Regimens of Magnesium Sulphate in Patients With Severe P... |
| NCT05284474 | NA | NOT_YET_RECRUITING | 340 | Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Fe... |
| NCT02911701 | PHASE4 | COMPLETED | 100 | Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia Wit... |
| NCT04462367 | N/A | ACTIVE_NOT_RECRUITING | 180 | Clinical and Laboratory Predictors of COVID-19 Progression and Maternal and Peri... |
| NCT04468763 | N/A | UNKNOWN | 263 | Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future... |
| NCT03112551 | NA | UNKNOWN | 100 | Safety and Efficacy of Twelve Hours Duration of Magnesium Sulphate in the Treatm... |
| NCT03494517 | N/A | UNKNOWN | 35 | Detection of Epileptiform Activity in Severe Preeclampsia: A Prospective Observa... |
| NCT02835339 | PHASE4 | COMPLETED | 66 | Randomized Trial of Magnesium Sulfate in Obese Preeclamptic Women |
| NCT05358483 | N/A | RECRUITING | 1000 | The PROMISE Study: PROspective Study of Mothers' and Infants' Social and Epidemi... |
| NCT05119101 | PHASE1 | UNKNOWN | 100 | Dexamedtomidine as Adjuvant to Magnesium Sulphate for Intracranial Pressure Cont... |
| NCT05687669 | PHASE4 | COMPLETED | 170 | Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their ... |
| NCT02443259 | N/A | COMPLETED | 60 | Short Term Neurobehavioural Outcomes in Late Preterm Neonates Born to Pre Eclamp... |
| NCT03928691 | N/A | UNKNOWN | 400 | Impact of Body Mass Index on Serum Maternal and Fetal Magnesium Level in Pregnan... |
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 9794688 | 1998 | Article | Obstetrics and gynecology | Magnesium sulfate therapy in preeclampsia and eclampsia. |
| 39110688 | 2024 | Article | PloS one | Perspectives of providing magnesium sulfate to patients with preeclampsia and ec... |
| 2288560 | 1990 | Article | American journal of obstetrics | Magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia. |
| 31527059 | 2019 | Article | Global health, science and pra | It Takes a System: Magnesium Sulfate for Prevention of Eclampsia in a Resource-L... |
| 2672428 | 1989 | Article | Stroke | Action of magnesium sulfate in the treatment of preeclampsia-eclampsia. |
| 490496 | 1979 | Article | The Journal of reproductive me | The use of magnesium sulfate in preeclampsia-eclampsia. |
| 16978425 | 2006 | Article | Obstetrical & gynecological su | Cerebral hemodynamics in preeclampsia: cerebral perfusion and the rationale for ... |
| 38865319 | 2024 | Article | PloS one | Randomized trial to compare acceptability of magnesium sulphate administration f... |
| 7726272 | 1995 | Article | American journal of obstetrics | Blindness associated with preeclampsia and eclampsia. |
| 17441885 | 2007 | Article | The journal of obstetrics and | Ionized and total magnesium concentration in patients with severe preeclampsia-e... |
| 36413336 | 2023 | Article | Biological trace element resea | Critical Hypermagnesemia in Preeclamptic Women Under a Magnesium Sulfate Regimen... |
| 41054655 | 2025 | Article | Cureus | Magnesium Sulfate in Pediatric Emergency Medicine: Pharmacology, Evidence, and C... |
| 28867883 | 2017 | Article | Journal of obstetrics and gyna | Examining the Use of Magnesium Sulfate to Treat Pregnant Women with Preeclampsia... |
| 8319988 | 1993 | Article | Hypertension (Dallas, Tex. : 1 | Hypertension in pregnancy. |
| 25353716 | 2015 | Article | Acta obstetricia et gynecologi | Reducing maternal mortality from preeclampsia and eclampsia in low-resource coun... |
| 28301493 | 2017 | Article | PloS one | Obstetrician's risk perception on the prescription of magnesium sulfate in sever... |
| 26069818 | 2012 | Article | Clinical kidney journal | Magnesium in disease. |
| 1566765 | 1992 | Article | American journal of obstetrics | Anticonvulsant effects of magnesium sulfate on hippocampal seizures: therapeutic... |
| 29470266 | 2018 | Article | MCN. The American journal of m | Posterior Reversible Encephalopathy Syndrome. |
| 23282276 | 2012 | Article | Revista medica del Instituto M | [Clinical guideline. Preeclampsia-eclampsia]. |
2. toxemia of pregnancy L1 100.00%
臨床試驗（50 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00004399 | NA | COMPLETED | 2000 | Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Ecl... |
| NCT01030627 | PHASE4 | COMPLETED | 85 | Treatment Approaches to Preeclampsia |
| NCT02396030 | PHASE4 | TERMINATED | 62 | Effectiveness and Safety of 1g/Hour vs. 2g/Hour of Magnesium Sulfate Maintenance... |
| NCT03210350 | N/A | COMPLETED | 30 | Effect of Magnesium Sulphate on the Intracranial Pressure of Preeclamptic Patien... |
| NCT05789381 | NA | WITHDRAWN | 0 | Patient Satisfaction and Abbreviated Postpartum Magnesium Sulfate for Preeclamps... |
| NCT00185900 | NA | COMPLETED | 192 | Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A ... |
| NCT04586348 | PHASE4 | ACTIVE_NOT_RECRUITING | 794 | Prenatal Iodine Supplementation and Early Childhood Neurodevelopment |
| NCT02647268 | NA | COMPLETED | 26 | Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in D... |
| NCT00344058 | NA | COMPLETED | 200 | Abbreviated Post-partum Magnesium Sulfate Seizure Prophylaxis in Preeclampsia: A... |
| NCT02619799 | PHASE2, PHASE3 | COMPLETED | 50 | A Comparative Study Between Intrathecal Magnesium Sulphate Versus Midazolam Alon... |
| NCT03549767 | NA | UNKNOWN | 241 | Randomized Trial to Compare Magnesium Sulphate Administration for Preeclampsia a... |
| NCT02317146 | PHASE2, PHASE3 | COMPLETED | 280 | A Novel Protocol for Postpartum Magnesium Sulfate in Severe Preeclampsia When th... |
| NCT01911494 | NA | COMPLETED | 87500 | The CLIP (Community Level Interventions for Pre-eclampsia) Cluster Randomized Co... |
| NCT02307201 | PHASE2, PHASE3 | COMPLETED | 1114 | Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia Receiv... |
| NCT04645719 | PHASE3 | UNKNOWN | 75 | Best Dose of Magnesium Sulfate Infusion in Obese. A Blind and Randomized Trial |
| NCT03318211 | PHASE4 | UNKNOWN | 100 | Continuation Versus Discontinuation of Magnesium Sulfate After Delivery in Women... |
| NCT06126068 | NA | COMPLETED | 120 | Comparison of Loading Dose Magnesium Sulphate With Prichard Regimen in the Manag... |
| NCT02091401 | PHASE4 | COMPLETED | 200 | A Randomized Open-label Study to Compare the Clinical Outcomes and Magnesium Ser... |
| NCT07220902 | PHASE3 | NOT_YET_RECRUITING | 1240 | Levetiracetam Compared to Magnesium Sulfate for Prevention of Eclamptic Seizure:... |
| NCT01360060 | N/A | COMPLETED | 503 | Analgesia After Cesarean Section |
| NCT03412552 | N/A | COMPLETED | 1238 | Risk Analysis of Intensive Care Management on Maternal and Fetal Outcome of Seve... |
| NCT04003688 | NA | COMPLETED | 74 | Strategy to Calculate Magnesium Sulfate Dose in Obese Patients. A Randomized and... |
| NCT05345132 | NA | UNKNOWN | 264 | Nifedipine Plus Magnesium Sulfate Versus Magnesium Sulfate Alone for Tocolysis i... |
| NCT04752475 | PHASE3 | COMPLETED | 82 | Lasix for the Prevention of De Novo Postpartum Hypertension: A Randomized Contro... |
| NCT06306040 | PHASE3 | NOT_YET_RECRUITING | 105 | Effect of Intravenous Nalbuphine Versus Magnesium Sulfate on Emergence Agitation... |
| NCT01801410 | PHASE3 | COMPLETED | 602 | Induction of Labour in Pre-eclamptic Women: a Randomised Trial Comparing the Fol... |
| NCT00293735 | PHASE2, PHASE3 | WITHDRAWN | 0 | Labetalol Versus MgSO4 for the Prevention of Eclampsia Trial (LAMPET) |
| NCT03237819 | PHASE3 | UNKNOWN | 74 | Interest of Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensiv... |
| NCT05610774 | NA | COMPLETED | 50 | Using Optic Nerve Sheath Diameter to Monitor Intracranial Tension in Pre-Eclampt... |
| NCT01408979 | PHASE4 | COMPLETED | 120 | Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsi... |
| NCT06563908 | NA | NOT_YET_RECRUITING | 784 | Lipiodol® For Enhancing Live Birth Rates In Infertile Couples Undergoing In Vitr... |
| NCT00666133 | NA | COMPLETED | 304 | Treatment Approaches for Preeclampsia in Low-Resource Settings |
| NCT04387565 | N/A | COMPLETED | 210 | Analysis of Maternal Plasma/Urine/Hair Magnesium and Vanadium Levels in Preeclam... |
| NCT02454322 | N/A | COMPLETED | 300 | The Effect of Magnesium on Maternal Mood, Cognitive Function, and Birth Experien... |
| NCT04492072 | NA | COMPLETED | 150 | Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation fo... |
| NCT03863613 | NA | TERMINATED | 219 | The Effectiveness of Cervical Pessary Compared to Cervical Cerclage With or With... |
| NCT04474704 | NA | COMPLETED | 53 | Use of Cheetah® Non-invasive Cardiac Monitoring System to Guide Discontinuation ... |
| NCT06463652 | NA | RECRUITING | 328 | Cervical Cerclage With Vaginal Progesterone Versus Vaginal Progesterone Only for... |
| NCT05671081 | PHASE3 | COMPLETED | 60 | Dexmedetomidine Versus Magnesium Sulfate in Ultrasound Guided Bilateral Bi-level... |
| NCT05283473 | N/A | COMPLETED | 64 | Serum Concentration of Magnesium Attained in Magnesium Sulfate Therapy in Pregna... |
| NCT01846156 | PHASE3 | COMPLETED | 240 | The Best Magnesium Sulphate Protocol for Severe Pre-eclampsia : A Randomized Con... |
| NCT03891498 | NA | UNKNOWN | 100 | The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal... |
| NCT04501289 | NA | COMPLETED | 114 | Low Dose Magnesium Sulphate Versus Standard Pritchard Regimen In Management Of S... |
| NCT01972659 | PHASE4 | COMPLETED | 80 | Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Block... |
| NCT04300985 | PHASE3 | COMPLETED | 90 | Magnesium Sulfate Versus Dexmedetomidine on Anesthesia Awakening. Randomized Cli... |
| NCT05558969 | NA | COMPLETED | 30 | The Effect of Prophylactic Magnesium Use in Pregnant Women on Reversal of Neurom... |
| NCT06791668 | N/A | RECRUITING | 400 | Comparison of Different Regimens of Magnesium Sulphate in Patients With Severe P... |
| NCT04300322 | NA | UNKNOWN | 804 | The Effectiveness of Cervical Pessary Versus Vaginal Progesterone for the Preven... |
| NCT05284474 | NA | NOT_YET_RECRUITING | 340 | Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Fe... |
| NCT05624151 | PHASE3 | COMPLETED | 75 | Dexmedetomidine Versus Magnesium Sulphate Added to Bupivacaine in Infraorbital N... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 10803454 | 2000 | Article | Clinical pharmacokinetics | Magnesium sulfate in eclampsia and pre-eclampsia: pharmacokinetic principles. |
| 36822712 | 2023 | Article | Obstetrics and gynecology clin | Magnesium Sulfate Use in Pregnancy for Preeclampsia Prophylaxis and Fetal Neurop... |
| 38669914 | 2024 | Article | Pregnancy hypertension | Magnesium sulfate in preeclampsia: Broad indications, not only in neurological s... |
| 37415326 | 2023 | Article | Medical science monitor : inte | Eclampsia: A Critical Pregnancy Complication Demanding Enhanced Maternal Care: A... |
| 12057549 | 2002 | Article | Lancet (London, England) | Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? ... |
| 21069663 | 2010 | Article | The Cochrane database of syste | Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. |
| 35704050 | 2022 | Article | The journal of maternal-fetal | Intrapartum magnesium sulfate exposure and obstetric hemorrhage risk. |
| 35271534 | 2022 | Article | Obstetrics and gynecology | Duration of Postpartum Magnesium Sulphate for the Prevention of Eclampsia: A Sys... |
| 34187284 | 2022 | Article | The journal of maternal-fetal | Duration of postpartum magnesium sulfate for seizure prophylaxis in women with p... |
| 22060216 | 2011 | Article | Journal of midwifery & women's | Magnesium sulfate: past, present, and future. |
| 35656755 | 2022 | Article | International journal of gynae | The effect of magnesium sulfate on maternal serum electrolytes and parathyroid h... |
| 32642964 | 2020 | Article | Drugs in R&D | Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated ... |
| 38872116 | 2024 | Article | BMC pregnancy and childbirth | Population pharmacokinetics and dose optimization of magnesium sulfate in Chines... |
| 2225578 | 1990 | Article | Clinical obstetrics and gyneco | Eclampsia. |
| 26599617 | 2016 | Article | BJOG : an international journa | Clinical pharmacokinetic properties of magnesium sulphate in women with pre-ecla... |
| 452989 | 1979 | Article | American family physician | Toxemia of pregnancy. |
| 8879973 | 1996 | Article | Drug safety | Role of magnesium sulfate in seizure prevention in patients with eclampsia and p... |
| 31527059 | 2019 | Article | Global health, science and pra | It Takes a System: Magnesium Sulfate for Prevention of Eclampsia in a Resource-L... |
| 9794688 | 1998 | Article | Obstetrics and gynecology | Magnesium sulfate therapy in preeclampsia and eclampsia. |
| 26767791 | 2016 | Article | American journal of obstetrics | Pharmacokinetics and placental transfer of magnesium sulfate in pregnant women. |
3. thrombotic disease L2 99.90%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT04844801 | NA | RECRUITING | 240 | Comparison of Three Care Strategies in Cases of New-onset Supraventricular Arrhy... |
| NCT03237819 | PHASE3 | UNKNOWN | 74 | Interest of Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensiv... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35615616 | 2021 | Article | Indian journal of critical car | Preeclampsia and Related Problems. |
| 26747754 | 2016 | Article | Digestive and liver disease : | AISF position paper on liver disease and pregnancy. |
| 37867165 | 2023 | Article | Intensive care medicine | Magnesium sulphate in patients with thrombotic thrombocytopenic purpura (MAGMAT)... |
| 32938758 | 2020 | Article | Open heart | Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and CO... |
| 8024163 | 1994 | Article | Angiology | Effect of magnesium sulfate infusion on circulating levels of noradrenaline and ... |
| 27749350 | 2016 | Article | Anesthesia and analgesia | Spine Surgery and Blood Loss: Systematic Review of Clinical Evidence. |
| 19566552 | 2009 | Article | The Australian & New Zealand j | Guidelines for the management of hypertensive disorders of pregnancy 2008. |
| 27568839 | 2016 | Article | European journal of pharmacolo | Anti-inflammatory and anti-thrombotic effects of zingerone in a rat model of myo... |
| 3724238 | 1986 | Article | Magnesium | Prompt termination and/or prevention of cold-pressor-stimulus-induced vasoconstr... |
| 22463492 | 2012 | Article | International journal of strok | Progressive lacunar stroke: review of mechanisms, prognostic features, and putat... |
| 8519163 | 1993 | Article | Clinical physiology (Oxford, E | Effects of cold pressor test on circulating atrial natriuretic peptide 99-126 (A... |
| 3441141 | 1987 | Article | Magnesium | Effect of magnesium sulfate on thrombus formation following partial arterial con... |
| 34784343 | 2021 | Article | The American journal of case r | Reversible Cerebral Vasoconstriction Syndrome in a Background of Eclampsia Respo... |
| 14506544 | 2003 | Article | Journal of cardiovascular phar | A prospective, nonrandomized, open-labeled pilot study investigating the use of ... |
| 14168822 | 1964 | Article | The Practitioner | PARENTERAL MAGNESIUM SULPHATE IN ARTERIAL DISEASE. |
| 38803431 | 2024 | Article | Frontiers in pharmacology | Expectant management for umbilical artery thrombosis in the third trimester of p... |
| 25738044 | 2015 | Article | Journal of clinical and diagno | Cerebral venous sinus thrombosis and posterior reversible encephalopathy syndrom... |
| 7368083 | 1980 | Article | Surgery | Effect of magnesium sulfate on platelet deposition in rabbits following temporar... |
| 8819258 | 1996 | Article | Thrombosis and haemostasis | Magnesium inhibits platelet activity--an in vitro study. |
| 7475761 | 1995 | Article | Lancet (London, England) | Magnesium sulphate increases plasma noradrenaline and neuropeptide-Y-like immuno... |
4. pharyngitis L1 99.61%
臨床試驗（12 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT07213037 | PHASE3 | NOT_YET_RECRUITING | 102 | Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Sup... |
| NCT02100293 | NA | COMPLETED | 84 | Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium |
| NCT07381036 | NA | NOT_YET_RECRUITING | 150 | Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Preven... |
| NCT01923831 | NA | COMPLETED | 146 | Comparison of the Effect of Magnesium Sulfate and Dexamethasone on Postoperative... |
| NCT07123714 | NA | NOT_YET_RECRUITING | 140 | Effect of Preoperative Nebulized Magnesium Sulfate on Post-intubation Stress Res... |
| NCT03729973 | PHASE3 | COMPLETED | 100 | Comparing The Efficacy Of Preoperative Nebulized: Ketamine, Magnesium Sulfate, a... |
| NCT04462367 | N/A | ACTIVE_NOT_RECRUITING | 180 | Clinical and Laboratory Predictors of COVID-19 Progression and Maternal and Peri... |
| NCT04705948 | NA | COMPLETED | 60 | Comparing the Effect of Ketamine and Magnesium Sulfate Gargling With Placebo on ... |
| NCT02826746 | NA | COMPLETED | 20 | Effect of Intravenous Magnesium on Postoperative Sore Throat After Thyroidectomy |
| NCT05714540 | PHASE4 | UNKNOWN | 90 | The Effect of Oropharyngeal Pack Soaked With Ketamine or Magnesium Sulphate on P... |
| NCT07131033 | PHASE1, PHASE2 | ACTIVE_NOT_RECRUITING | 120 | Effects of Perioperative Intravenous Infusion Esketamine Combined With Magnesium... |
| NCT06091631 | NA | COMPLETED | 100 | Effect of Magnesium Sulfate Nebulization on Postoperative Sore Throat and Stress... |
相關文獻（12 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 37929508 | 2024 | Article | Medical gas research | Comparison of adding magnesium sulfate, dexmedetomidine and ondansetron to lidoc... |
| 40098904 | 2025 | Article | Drug design, development and t | Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulf... |
| 28183544 | 2017 | Article | Journal of clinical anesthesia | Magnesium sulfate accelerates the onset of low-dose rocuronium in patients under... |
| 38693477 | 2024 | Article | BMC anesthesiology | Role of preoperative zinc, magnesium and budesonide gargles in Postoperative Sor... |
| 27275043 | 2016 | Article | Journal of anaesthesiology, cl | Effect of magnesium sulfate nebulization on the incidence of postoperative sore ... |
| 39780052 | 2025 | Article | BMC anesthesiology | The effect of preoperative topical magnesium sulfate spraying in the oropharynge... |
| 31119554 | 2019 | Article | Canadian journal of anaesthesi | Topical application of magnesium to prevent intubation-related sore throat in ad... |
| 35089202 | 2022 | Article | Medicine | Nebulized fentanyl for respiratory symptoms in patients with COVID-19 (ventanyl ... |
| 26516308 | 2015 | Article | International journal of medic | A Randomized, Double-blind, Non-inferiority Trial of Magnesium Sulphate versus D... |
| 22593134 | 2012 | Article | British journal of anaesthesia | Postoperative sore throat: a multifactorial problem. |
| 22157461 | 2012 | Article | British journal of anaesthesia | Nebulized magnesium for prevention of postoperative sore throat. |
| 960443 | 1976 | Article | Vestnik otorinolaringologii | [Protective effect of magnesium in sensitization (clinico-experimental study)]. |
5. nasal cavity disease L3 99.59%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT04462367 | N/A | ACTIVE_NOT_RECRUITING | 180 | Clinical and Laboratory Predictors of COVID-19 Progression and Maternal and Peri... |
6. psychotic disorder L2 99.50%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT06702488 | PHASE1 | RECRUITING | 58 | The Efficacy of Dexmedetomidine and Magnesium Sulfate in Cognitive Dysfunction |
| NCT05669417 | PHASE2, PHASE3 | TERMINATED | 265 | Randomized Controlled Trial of Magnesium Sulfate Versus Placebo on the Preventio... |
相關文獻（12 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 2497643 | 1989 | Article | American journal of kidney dis | The effects of administration of lithium salts and magnesium sulfate on the seru... |
| 5131870 | 1971 | Article | The Journal of laboratory and | Therapy of delirium tremens with urea (or dexamethasone) and magnesium sulfate. |
| 5259585 | 1969 | Article | Annals of the New York Academy | The relationship of hypomagnesemia and alkalosis to alcohol withdrawal symptoms. |
| 4289114 | 1967 | Article | Southern medical journal | Management of withdrawal from alcohol (including delirium tremens). |
| 21189701 | 2010 | Article | The Journal of the Association | Primary hypoparathyroidism: psychosis in postpartum period. |
| 4030178 | 1985 | Article | The International journal of t | Clinical experience with 781 cases of alcoholism evaluated and treated on an inp... |
| 4393191 | 1967 | Article | Journal de medecine de Lyon | [On the treatment of delirium tremens. Apropos of 414 cases]. |
| 20354061 | 2011 | Article | Human & experimental toxicolog | Intoxication by large amounts of barium nitrate overcome by early massive K supp... |
| 14854267 | 1951 | Article | Rassegna di studi psichiatrici | [Magnesium sulfate in alcoholic psychoses]. |
| 14015718 | 1963 | Article | Belgisch tijdschrift voor gene | [Chronic alcoholism and its treatment]. |
| 6113628 | 1980 | Article | Revista medica de Chile | [Pharmacotherapy of the alcohol withdrawal syndrome (author's transl)]. |
| 5745947 | 1968 | Article | Laval medical | [Comparative study of chlordiazepoxide and hypertonic MgSO4 in the alcohol withd... |
7. acute laryngopharyngitis L5 99.47%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
8. headache disorder L1 99.36%
臨床試驗（15 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT05789381 | NA | WITHDRAWN | 0 | Patient Satisfaction and Abbreviated Postpartum Magnesium Sulfate for Preeclamps... |
| NCT00344058 | NA | COMPLETED | 200 | Abbreviated Post-partum Magnesium Sulfate Seizure Prophylaxis in Preeclampsia: A... |
| NCT04814381 | PHASE4 | RECRUITING | 90 | Evaluation of the Efficacy of a Single Infusion of Ketamine Combined With Magnes... |
| NCT03412552 | N/A | COMPLETED | 1238 | Risk Analysis of Intensive Care Management on Maternal and Fetal Outcome of Seve... |
| NCT06376916 | PHASE3 | RECRUITING | 153 | Atrial Tachycardia Reduction With Intravenous Use of Magnesium (ATRIUM) Study: C... |
| NCT06791668 | N/A | RECRUITING | 400 | Comparison of Different Regimens of Magnesium Sulphate in Patients With Severe P... |
| NCT05967442 | PHASE3 | COMPLETED | 157 | A Randomized, Placebo-Controlled, Double-Blind Study of the Effects of Magnesium... |
| NCT06920576 | PHASE1, PHASE2 | ACTIVE_NOT_RECRUITING | 144 | Effect of Perioperative Intravenous Infusion of Esketamine or Magnesium Sulphate... |
| NCT05843812 | N/A | UNKNOWN | 104 | "Evaluation of the Clinical Response to Magnesium Sulfate as an Adjuvant in Anes... |
| NCT04462367 | N/A | ACTIVE_NOT_RECRUITING | 180 | Clinical and Laboratory Predictors of COVID-19 Progression and Maternal and Peri... |
| NCT03112551 | NA | UNKNOWN | 100 | Safety and Efficacy of Twelve Hours Duration of Magnesium Sulphate in the Treatm... |
| NCT06272916 | N/A | NOT_YET_RECRUITING | 630 | Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Pre... |
| NCT05227716 | PHASE4 | UNKNOWN | 104 | Evaluation of the Clinical Response to Magnesium Sulfate as an Adjunct in the An... |
| NCT04225793 | NA | UNKNOWN | 98 | Comparative Analysis of the Osmotic Laxative Application Efficiency and Safety E... |
| NCT02523911 | NA | WITHDRAWN | 0 | Sodium Sulfate/Potassium Sulfate/Magnesium Sulfate Bowel Preparation With and Wi... |
相關文獻（19 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35177218 | 2022 | Article | American journal of obstetrics | Postpartum preeclampsia or eclampsia: defining its place and management among th... |
| 38307660 | 2024 | Article | Handbook of clinical neurology | Status migrainosus. |
| 30198804 | 2018 | Article | Expert opinion on pharmacother | Treating status migrainosus in the emergency setting: what is the best strategy? |
| 25622379 | 2014 | Article | Acta anaesthesiologica Belgica | Preeclampsia: an update. |
| 41216917 | 2025 | Article | The Cochrane database of syste | Magnesium supplementation for migraine prophylaxis. |
| 28286809 | 2017 | Article | Emergency (Tehran, Iran) | Ketorolac versus Magnesium Sulfate in Migraine Headache Pain Management; a Preli... |
| 2802287 | 1989 | Article | Annals of emergency medicine | Postpartum eclampsia. |
| 31498421 | 2019 | Article | The Cochrane database of syste | Magnesium for treating sickle cell disease. |
| 28409830 | 2017 | Article | The Cochrane database of syste | Magnesium for treating sickle cell disease. |
| 1840336 | 1991 | Article | Acta Universitatis Palackianae | Magnesium and its combination with cinnarizine in the long-term treatment of hea... |
| 25278139 | 2015 | Article | The Journal of emergency medic | Comparison of therapeutic effects of magnesium sulfate vs. dexamethasone/metoclo... |
| 35615616 | 2021 | Article | Indian journal of critical car | Preeclampsia and Related Problems. |
| 9523054 | 1998 | Article | Clinical neuroscience (New Yor | Role of magnesium in the pathogenesis and treatment of migraines. |
| 28757917 | 2017 | Article | The Korean journal of pain | Intravenous caffeine citrate vs. magnesium sulfate for reducing pain in patients... |
| 3619172 | 1987 | Article | Annals of emergency medicine | Late postpartum eclampsia. |
| 33128280 | 2020 | Article | Headache | Ketamine-Magnesium for Refractory Chronic Cluster Headache: A Case Series. |
| 40225988 | 2025 | Article | American journal of translatio | Effects of labetalol plus magnesium sulfate on brain symptoms and pregnancy outc... |
| 11719739 | 2001 | Article | Annals of emergency medicine | Randomized clinical trial of intravenous magnesium sulfate as an adjunctive medi... |
| 27017021 | 2016 | Article | Seminars in pediatric neurolog | Management of Primary Headache in the Emergency Department and Inpatient Headach... |
9. trigeminal autonomic cephalalgia L2 99.18%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT04814381 | PHASE4 | RECRUITING | 90 | Evaluation of the Efficacy of a Single Infusion of Ketamine Combined With Magnes... |
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 33128280 | 2020 | Article | Headache | Ketamine-Magnesium for Refractory Chronic Cluster Headache: A Case Series. |
| 8550360 | 1995 | Article | Headache | Intravenous magnesium sulfate relieves cluster headaches in patients with low se... |
| 28670718 | 2017 | Article | Headache | Ketamine Infusion Combined With Magnesium as a Therapy for Intractable Chronic C... |
10. treatment-refractory schizophrenia L5 99.11%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
台灣上市資訊
許可證狀態 (精選有效許可證)
| 許可證字號 | 商品名 | 劑型 | 持證商 | 效期 |
|---|---|---|---|---|
| 衛署藥製字第013386號 | 濟生硫酸鎂注射液 | 注射劑 | 濟生醫藥生技 | 2028/05/25 |
| 衛署藥製字第047652號 | 欣滿福注射液 | 注射劑 | 台灣拜耳 | 2030/12/20 |
| 多項藥陸輸字號 | 硫酸鎂 | 原料藥 | 多家 | 各異 |
核准適應症
- 產科用途：
- 子癇症 (Eclampsia)
- 子癇前症 (Preeclampsia)
- 妊娠毒血症
- 產科全身麻醉輔助
- 抗痙攣：
- 抗痙攣藥
- 電解質補充：
- 體內鎂離子缺乏時之補充
- 其他：
- 瀉劑/緩瀉劑
- 靜脈營養輸注
- 維他命與礦物質缺乏症
安全性考量
藥物交互作用 (DDI)
嚴重 (Major) 交互作用
| 併用藥物 | 影響說明 |
|---|---|
| Amikacin, Gentamicin (氨基糖苷類抗生素) | 增強神經肌肉阻斷效應，可能導致呼吸抑制 |
| Neuromuscular blockers (Cisatracurium 等) | 協同增強神經肌肉阻斷 |
| Nifedipine, 其他鈣通道阻斷劑 | 增強低血壓及神經肌肉阻斷風險 |
中度 (Moderate) 交互作用
| 併用藥物類別 | 代表藥物 | 影響 |
|---|---|---|
| 利尿劑 | Furosemide, HCTZ | 增加電解質流失 |
| ACE 抑制劑 | Captopril, Benazepril | 可能加強低血壓效應 |
| SGLT2 抑制劑 | Canagliflozin, Empagliflozin | 電解質異常風險 |
| 抗癲癇藥 | Carbamazepine | 藥物代謝影響 |
| 瀉劑 | Bisacodyl, Picosulfuric acid | 電解質流失加劇 |
| beta-2 促效劑 | Salbutamol, Formoterol | 低血鉀風險 |
| 顯影劑 | Diatrizoate, Iothalamic acid | 腎功能考量 |
重要警語與監測
- 鎂中毒風險：
- 治療範圍窄 (4-7 mEq/L)
- 需監測深部腱反射消失 (早期徵兆)
- 呼吸抑制可能在 12-15 mEq/L 發生
- 心跳停止可能在 >15 mEq/L 發生
- 解毒劑：
- Calcium gluconate 為鎂中毒的首選解毒劑
- 應隨時備妥
- 監測項目：
- 尿量 (需 >= 25-30 mL/hr)
- 深部腱反射
- 呼吸頻率 (需 >= 12 次/分)
- 血清鎂濃度
- 腎功能考量：
- 鎂由腎臟排泄
- 腎功能不全者需減量或延長給藥間隔
禁忌症
- 心臟傳導阻滯
- 嚴重腎功能不全
- 重症肌無力
- 已知對 MgSO4 過敏
特殊族群
- 孕婦：核准用於子癇前症/子癇症，但需嚴密監測
- 新生兒：產前使用 MgSO4 可能導致新生兒低鈣血症及骨骼異常 (長期使用時)
- 哺乳婦女：鎂可進入乳汁，但量不大
- 腎功能不全：需調整劑量
藥物-疾病注意事項 (DDSI)
資料來源：DDInter 2.0（原文內容請參閱該網站）
Arrhythmias, Cardiac 🟡 Moderate
- 應謹慎使用本藥物。風險包括：心律不整、癲癇發作。可能有嚴重不良反應。
Depressive Disorder 🟢 Minor
- 需定期監測。
Inflammatory Bowel Diseases 🟢 Minor
- 本藥物在此情況下禁用。
Intestinal Obstruction 🟢 Minor
- 本藥物在此情況下禁用。
Heart Diseases 🟢 Minor
- 本藥物在此情況下禁用。需密切監測。
Pre-Eclampsia 🟢 Minor
- 注意事項：Intravenous magnesium should not be given to mothers with preeclampsia during the two hours preceding delivery…
腎臟疾病 🟢 Minor
- 需定期監測。風險包括：低血壓。
重症肌無力 🟢 Minor
- 本藥物在此情況下禁用。可能危及生命。
結論與下一步
藥師評估
| 評估項目 | 結論 |
|---|---|
| 預測可信度 | 極高 - 與核准適應症一致 |
| 機轉合理性 | 極高 - 機轉明確 |
| 臨床證據強度 | 極高 - 多個大型 RCT |
| 證據等級 | L1 |
| 臨床實用性 | 已是標準治療 |
建議
- 臨床應用現況：
- Magnesium sulfate 已是子癇前症/子癇症的全球標準治療
- 台灣各醫院產科均有常規使用
- 持續研究方向：
- 劑量優化 (特別是肥胖族群)
- 縮短產後療程的安全性
- 新型給藥裝置在資源有限地區的應用
- 藥師角色：
- 確保醫療單位備有 MgSO4 及解毒劑
- 提供給藥速度與監測項目的教育
- 注意藥物交互作用 (特別是氨基糖苷類抗生素)
- 實務提醒：
- 標準負荷劑量：4-6g IV (20-30 分鐘)
- 標準維持劑量：1-2g/hr IV 持續輸注
- 確認解毒劑 Calcium gluconate 隨時可用
- 監測膝反射、呼吸、尿量
證據等級說明
L1 (多個 RCT)：Magnesium sulfate 用於子癇前症/子癇症具有最高等級的臨床證據，包括超過 30 項臨床試驗及多個大型多國 RCT (如 Magpie Trial)，已被 WHO 列為基本藥物。
本筆記由 TxGNN 老藥新用預測系統生成，僅供研究參考，不構成醫療建議。
生成日期：2026-02-11
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引用本報告
如需引用本報告，請使用以下格式：
APA 格式：
TwTxGNN. (2026). Magnesium Sulfate老藥新用驗證報告. https://twtxgnn.yao.care/drugs/magnesium_sulfate/
BibTeX 格式：
@misc{twtxgnn_magnesium_sulfate,
title = {Magnesium Sulfate老藥新用驗證報告},
author = {TwTxGNN Team},
year = {2026},
url = {https://twtxgnn.yao.care/drugs/magnesium_sulfate/}
}
免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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