Famotidine
證據等級: L5 | 預測適應症: 10 個
## 藥師評估報告
Famotidine 藥師評估筆記
一句話總結
Famotidine 是 H2 受體拮抗劑，TxGNN 預測其可用於十二指腸胃食道逆流和消化性潰瘍，這些預測與原核准適應症高度重疊，具有充分的臨床證據支持。
快速總覽
| 項目 | 內容 |
|---|---|
| 藥物名稱 | Famotidine (法莫替丁) |
| DrugBank ID | DB00927 |
| 台灣商品名 | 諾得舒胃福治潰膜衣錠 |
| 原核准適應症 | 胃潰瘍、十二指腸潰瘍、逆流性食道炎、Zollinger-Ellison 症候群 |
| 預測新適應症 | peptic esophagitis、gastrin secretion abnormality、duodenogastric reflux、duodenal obstruction、duodenal ulcer (disease)、active peptic ulcer disease、peptic ulcer perforation、gastrojejunal ulcer、esophagitis (disease)、Zollinger-Ellison syndrome |
| 最高預測分數 | 0.9999 (duodenogastric reflux) |
| 證據等級 | L2 (單一 RCT/多個 Phase 2) |
預測適應症詳細分析
1. duodenogastric reflux L4 99.99% 主要分析
2. duodenal obstruction L1 99.99%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00450216 | PHASE3 | COMPLETED | 906 | A Randomized, Double-Blind, Phase 3 Study of the Efficacy and Safety of HZT-501 ... |
| NCT00450658 | PHASE3 | COMPLETED | 627 | A Randomized, Double-Blind, Phase 3 Study of the Efficacy and Safety of HZT-501 ... |
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 8165479 | 1994 | Article | Surgical endoscopy | Giant marginal ulcer. |
| 9306611 | 1997 | Article | Surgery today | Surgical treatment for duodenal involvement in Crohn's disease: report of a case... |
| 2816881 | 1989 | Article | The American journal of gastro | Failure of single night-time dose of H2-receptor antagonists in the treatment of... |
3. active peptic ulcer disease L4 99.98%
相關文獻（19 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 9506245 | 1998 | Article | Drugs | Rabeprazole. |
| 2905237 | 1988 | Article | Drugs | Prostaglandins, H2-receptor antagonists and peptic ulcer disease. |
| 3310199 | 1987 | Article | Scandinavian journal of gastro | Ulcer pain mechanisms. The clinical features of active peptic ulcer disease and ... |
| 34798155 | 2022 | Article | International journal of pharm | Famotidine-loaded solid self-nanoemulsifying drug delivery system demonstrates e... |
| 39345794 | 2024 | Article | Toxicology research | Diospyros kaki fruit aqueous extract individual/combined with famotidine mitigat... |
| 2889257 | 1987 | Article | Scandinavian journal of gastro | Clinical benefits of intravenously administered famotidine in the treatment of u... |
| 25926722 | 2015 | Article | Drug design, development and t | Evaluation of combined famotidine with quercetin for the treatment of peptic ulc... |
| 2877912 | 1987 | Article | Gastroenterology | A multicenter, double-blind, randomized, placebo-controlled comparison of noctur... |
| 8865446 | 1996 | Article | Scandinavian journal of gastro | A review on treatment of bleeding peptic ulcer: a collaborative task of gastroen... |
| 26283843 | 2015 | Article | Journal of natural science, bi | Protective effects of ginger and marshmallow extracts on indomethacin-induced pe... |
| 1863945 | 1991 | Article | Clinical therapeutics | The efficacy and tolerability of famotidine and ranitidine on the healing of act... |
| 7594320 | 1995 | Article | Journal of clinical gastroente | Gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazol... |
| 1976583 | 1990 | Article | Hepato-gastroenterology | Acid secretion and acid suppression in pathogenesis and healing of peptic ulcer ... |
| 27888865 | 2016 | Article | Gastroenterologia y hepatologi | Advances in gastrointestinal bleeding. |
| 2877570 | 1986 | Article | The American journal of medici | A multicenter, randomized, double-blind study comparing famotidine with ranitidi... |
| 2570005 | 1989 | Article | Digestion | A multicenter, randomized, double-blind study comparing famotidine with cimetidi... |
| 2670647 | 1989 | Article | Digestion | A multicenter, randomized, double-blind study comparing a daily bedtime administ... |
| 1420739 | 1992 | Article | Alimentary pharmacology & ther | Omeprazole versus famotidine in the short-term treatment of duodenal ulcer disea... |
| 9690716 | 1998 | Article | Prostaglandins, leukotrienes, | Hypothesis: cis-unsaturated fatty acids as potential anti-peptic ulcer drugs. |
4. peptic ulcer perforation L1 99.98%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00683111 | PHASE4 | COMPLETED | 500 | Famotidine Compared With Esomeprazole in the Prevention of Ulcer Complications i... |
| NCT00450658 | PHASE3 | COMPLETED | 627 | A Randomized, Double-Blind, Phase 3 Study of the Efficacy and Safety of HZT-501 ... |
相關文獻（9 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 8165479 | 1994 | Article | Surgical endoscopy | Giant marginal ulcer. |
| 19837071 | 2010 | Article | Gastroenterology | Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-relat... |
| 21954519 | 2011 | Article | Prescrire international | Nonsteroidal anti-inflammatory drugs: add an anti-ulcer drug for patients at hig... |
| 10379475 | 1999 | Article | Italian journal of gastroenter | A clinical approach to management of patients with non-steroidal anti-inflammato... |
| 21387691 | 2011 | Article | Nihon rinsho. Japanese journal | [Strategy to manage low dose aspirin-induced gastrointestinal injury]. |
| 10063300 | 1998 | Article | Journal of the Indian Medical | Simple closure of perforated duodenal ulcer. |
| 12658910 | 2003 | Article | Wiener klinische Wochenschrift | [Adverse effects of non-steroidal anti-inflammatory drugs. A prevalence study in... |
| 2500018 | 1989 | Article | The American journal of medici | Sucralfate in the prevention of porcine experimental peptic ulceration. |
| 19391208 | 2009 | Article | Khirurgiia | [Antisecretory therapy strategy for patients with bleeding and perforated gastro... |
5. gastrojejunal ulcer L2 99.98%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00557349 | PHASE4 | COMPLETED | 40 | A Randomized, Double-blind Clinical Trial Comparing Zegerid Capsule to Famotidin... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35348552 | 2022 | Article | The Medical letter on drugs an | Drugs for GERD and peptic ulcer disease. |
| 2028638 | 1991 | Article | DICP : the annals of pharmacot | Famotidine and cardiac arrhythmia. |
| 8853932 | 1996 | Article | Clinical pharmacokinetics | Pharmacokinetics and pharmacodynamics of famotidine in paediatric patients. |
| 2892567 | 1988 | Article | British medical journal (Clini | Peptic ulceration. |
| 2875864 | 1986 | Article | Drugs | Famotidine. Pharmacodynamic and pharmacokinetic properties and a preliminary rev... |
| 16437673 | 2005 | Article | World journal of gastroenterol | Synergistic action of famotidine and chlorpheniramine on acetic acid-induced chr... |
| 2573505 | 1989 | Article | Drugs | Famotidine. An updated review of its pharmacodynamic and pharmacokinetic propert... |
| 2979698 | 1987 | Article | Alimentary pharmacology & ther | The place of famotidine in anti-ulcer therapy. |
| 1428035 | 1992 | Article | Indian journal of gastroentero | Comparative study of omeprazole and famotidine in the treatment of duodenal ulce... |
| 7594320 | 1995 | Article | Journal of clinical gastroente | Gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazol... |
| 8218758 | 1993 | Article | Alimentary pharmacology & ther | Omeprazole versus famotidine in the healing and relapse of duodenal ulcer. |
| 7594335 | 1995 | Article | Journal of clinical gastroente | Comparison of lansoprazole and famotidine for gastric ulcer by endoscopic ultras... |
| 22273212 | 2011 | Article | The American surgeon | Famotidine use and thrombocytopenia in the trauma patient. |
| 11943947 | 2002 | Article | European journal of gastroente | Effects of omeprazole and famotidine on fibroblast growth factor-2 during artifi... |
| 8835890 | 1996 | Article | Journal of clinical gastroente | Candida overgrowth after treatment of duodenal ulcer. A comparison of cimetidine... |
| 26165391 | 2015 | Article | The Physician and sportsmedici | Gastroprotective efficacy and safety of single-tablet ibuprofen/famotidine vs ib... |
| 3075106 | 1988 | Article | Acta gastroenterologica Latino | Famotidine in the short and long-term treatment of duodenal ulcer. |
| 25521726 | 2014 | Article | Journal of gastroenterology an | Comparison of teprenone and famotidine against gastroduodenal mucosal damage in ... |
| 2901868 | 1988 | Article | Bailliere's clinical gastroent | Histamine H2-receptor antagonists. |
| 1764869 | 1991 | Article | Clinical pharmacokinetics | Clinical pharmacokinetics of famotidine. |
6. abnormality of glucagon secretion L5 99.91%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
7. gastroduodenitis L4 99.80%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 25521726 | 2014 | Article | Journal of gastroenterology an | Comparison of teprenone and famotidine against gastroduodenal mucosal damage in ... |
| 9178671 | 1997 | Article | Gastroenterology | Famotidine for healing and maintenance in nonsteroidal anti-inflammatory drug-as... |
| 7846741 | 1994 | Article | Therapeutic drug monitoring | Pharmacokinetics and pharmacodynamics of famotidine in children with gastroduode... |
| 22066725 | 2012 | Article | Neurogastroenterology and moti | Influence of gastric acid on gastric emptying and gastric distension-induced pai... |
| 14653238 | 2003 | Article | Eksperimental'naia i kliniches | [Laser therapy and famotidine in complex restorative treatment of primary chroni... |
| 24531083 | 2014 | Article | Internal medicine (Tokyo, Japa | Geranylgeranylacetone, a gastromucoprotective drug, protects against NSAID-induc... |
| 10321752 | 1999 | Article | European journal of gastroente | Toxicity of NSAIDs in the stomach and duodenum. |
| 2905237 | 1988 | Article | Drugs | Prostaglandins, H2-receptor antagonists and peptic ulcer disease. |
| 32020689 | 2020 | Article | Journal of veterinary internal | Comparative analysis of the effect of IV administered acid suppressants on gastr... |
| 22388022 | 2012 | Article | The American journal of gastro | Editorial: single-tablet ibuprofen/double-dose famotidine for reduction of gastr... |
| 31229990 | 2020 | Article | Gut | Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind... |
| 11827362 | 2001 | Article | Digestive and liver disease : | Prophylaxis and treatment of non-steroidal anti-inflammatory drug-induced upper ... |
| 15704743 | 2004 | Article | Khirurgiia | [Study on the efficacy of famotidine (Quamatel) in the complex treatment of eros... |
| 10203432 | 1999 | Article | Canadian journal of gastroente | Management of nonsteroidal anti-inflammatory drug-induced gastroduodenal disease... |
| 8165833 | 1994 | Article | Zeitschrift fur Gastroenterolo | [High-dose omeprazole versus famotidine, pirenzepine and antacid in therapy of a... |
| 2129490 | 1990 | Article | Alimentary pharmacology & ther | NSAID-associated gastroduodenal damage: does famotidine protection extend into t... |
| 7970643 | 1994 | Article | Orvosi hetilap | [Famotidine in the treatment of gastroduodenal ulcer]. |
| 1783354 | 1991 | Article | Fukuoka igaku zasshi = Hukuoka | Effects of combination therapy with pirenzepine and famotidine on tetragastrin-s... |
| 40323256 | 2025 | Article | Biomarkers : biochemical indic | Aqueous Pistacia lentiscus leaves extract protects against ethanol-induced gastr... |
| 10392669 | 1999 | Article | Drug safety | Prophylaxis and treatment of NSAID-induced gastroduodenal disorders. |
8. peptic ulcer disease L1 99.72%
臨床試驗（14 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00683111 | PHASE4 | COMPLETED | 500 | Famotidine Compared With Esomeprazole in the Prevention of Ulcer Complications i... |
| NCT03667703 | PHASE4 | COMPLETED | 70 | Stress Ulcer Prophylaxis Versus Placebo - a Blinded Randomized Control Trial to ... |
| NCT00839488 | PHASE4 | TERMINATED | 6 | Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylax... |
| NCT01180179 | PHASE4 | COMPLETED | 228 | Prevention of Recurrent Idiopathic Gastroduodenal Ulcer Bleeding: a Double-blind... |
| NCT00229424 | PHASE3 | COMPLETED | 325 | Verification Study on Lafutidine in Mild Reflux Oesophagitis - Double Blind Cont... |
| NCT02551744 | NA | COMPLETED | 101 | Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in ... |
| NCT00978159 | PHASE4 | UNKNOWN | 128 | Esomeprazole or Famotidine in the Management of Aspirin Related Non-ulcer Dyspep... |
| NCT01408186 | PHASE3 | COMPLETED | 264 | Histamine-2 Receptor Antagonist Versus Proton-Pump Inhibitor for the Prevention ... |
| NCT02418312 | NA | COMPLETED | 228 | Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Pepti... |
| NCT00153673 | PHASE3 | COMPLETED | 200 | Phase III Study of a Double-Blind Randomized Comparison of Famotidine Plus Celec... |
| NCT00843063 | PHASE4 | COMPLETED | 161 | Famotidine vs. Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Er... |
| NCT04123899 | NA | UNKNOWN | 32 | An Open-Label, Randomized, Two-sequence, Two-period, Fasting Condition, Single O... |
| NCT00557349 | PHASE4 | COMPLETED | 40 | A Randomized, Double-blind Clinical Trial Comparing Zegerid Capsule to Famotidin... |
| NCT00450658 | PHASE3 | COMPLETED | 627 | A Randomized, Double-Blind, Phase 3 Study of the Efficacy and Safety of HZT-501 ... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35348552 | 2022 | Article | The Medical letter on drugs an | Drugs for GERD and peptic ulcer disease. |
| 2573505 | 1989 | Article | Drugs | Famotidine. An updated review of its pharmacodynamic and pharmacokinetic propert... |
| 2875864 | 1986 | Article | Drugs | Famotidine. Pharmacodynamic and pharmacokinetic properties and a preliminary rev... |
| 2905237 | 1988 | Article | Drugs | Prostaglandins, H2-receptor antagonists and peptic ulcer disease. |
| 34798155 | 2022 | Article | International journal of pharm | Famotidine-loaded solid self-nanoemulsifying drug delivery system demonstrates e... |
| 2869852 | 1986 | Article | Clinical pharmacy | Current concepts in clinical therapeutics: peptic ulcer disease. |
| 2892567 | 1988 | Article | British medical journal (Clini | Peptic ulceration. |
| 3061768 | 1988 | Article | Drugs | The significance of gastrin in the pathogenesis and therapy of peptic ulcer dise... |
| 7551483 | 1995 | Article | British journal of hospital me | Drug therapy of peptic ulcer disease. |
| 40914367 | 2025 | Article | International journal of biolo | Famotidine-loaded chitosan hybridized fibroin nanoparticles exhibit outstanding ... |
| 25926722 | 2015 | Article | Drug design, development and t | Evaluation of combined famotidine with quercetin for the treatment of peptic ulc... |
| 1764869 | 1991 | Article | Clinical pharmacokinetics | Clinical pharmacokinetics of famotidine. |
| 16437673 | 2005 | Article | World journal of gastroenterol | Synergistic action of famotidine and chlorpheniramine on acetic acid-induced chr... |
| 2901868 | 1988 | Article | Bailliere's clinical gastroent | Histamine H2-receptor antagonists. |
| 2883883 | 1987 | Article | The American journal of gastro | Effect of famotidine on hepatic hemodynamics and peptic ulcer. |
| 7594320 | 1995 | Article | Journal of clinical gastroente | Gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazol... |
| 1428035 | 1992 | Article | Indian journal of gastroentero | Comparative study of omeprazole and famotidine in the treatment of duodenal ulce... |
| 2210613 | 1990 | Article | Hepato-gastroenterology | Effects of hepatic disease on the pharmacokinetics of famotidine and effects of ... |
| 2889257 | 1987 | Article | Scandinavian journal of gastro | Clinical benefits of intravenously administered famotidine in the treatment of u... |
| 7594335 | 1995 | Article | Journal of clinical gastroente | Comparison of lansoprazole and famotidine for gastric ulcer by endoscopic ultras... |
9. multiple endocrine neoplasia L2 99.69%
臨床試驗（3 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT05417594 | PHASE1, PHASE2 | RECRUITING | 695 | A Modular Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tole... |
| NCT01248962 | PHASE2 | COMPLETED | 146 | Standard Infusion Carboplatin Versus Prophylactic Extended Infusion Carboplatin ... |
| NCT00451880 | PHASE1 | COMPLETED | 180 | A Phase 1 Dose-Escalation Study of the Safety and Pharmacokinetics of XL281 Admi... |
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 2874977 | 1986 | Article | Drugs | Current management of Zollinger-Ellison syndrome. |
10. acne (disease) L5 99.55%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
台灣上市資訊
Famotidine 在台灣有多種劑型和品牌上市：
| 許可證字號 | 中文品名 | 劑型 | 許可證持有者 | 狀態 |
|---|---|---|---|---|
| 衛署藥製字第037684號 | 諾得舒胃福治潰膜衣錠40毫克 | 膜衣錠 | 約克製藥股份有限公司 | 有效 |
| 衛署藥製字第034815號 | 胃康舒膜衣錠20毫克 | 膜衣錠 | 永信藥品工業股份有限公司 | 有效 |
| 衛署藥製字第036152號 | 法瑪乳頓膠囊20毫克 | 膠囊 | 中國化學製藥股份有限公司 | 有效 |
劑型多樣：錠劑、膠囊、注射劑、口溶錠等
安全性考量
已知風險
- 整體安全性良好：H2 拮抗劑是最安全的抑酸藥物之一
- 頭痛：最常見的副作用(約 4%)
- 腸胃不適：便秘、腹瀉
- 血液學異常：罕見的血小板減少症
藥物交互作用
根據 DDInter 資料庫：
| 交互作用藥物 | 嚴重度 | 說明 |
|---|---|---|
| Ketoconazole | Moderate | 減少 ketoconazole 吸收 |
| Atazanavir | Major | 減少 atazanavir 吸收，避免併用 |
| Delavirdine | Major | 減少 delavirdine 吸收 |
| Dasatinib | Moderate | 可能減少吸收 |
特殊族群
- 孕婦：B 級，相對安全
- 哺乳：分泌至乳汁，建議謹慎使用
- 腎功能不全：CrCl < 50 mL/min 需減量
- 老年人：一般無需調整劑量
藥物-食物交互作用 (DFI)
咖啡因（咖啡、茶、可樂） 🟢 Minor
- 影響：H2 阻斷劑可能增加咖啡因吸收
- 建議：無需特別限制
藥物-疾病注意事項 (DDSI)
資料來源：DDInter 2.0（原文內容請參閱該網站）
腎臟疾病 🟡 Moderate
- 可能需要調整劑量。風險包括：癲癇發作。可能有嚴重不良反應。
Peptic Ulcer Hemorrhage 🟢 Minor
- 不應使用本藥物。可能有嚴重不良反應。
結論與下一步
整體評估
此預測已有充分臨床證據支持，原因如下：
- 預測適應症與原核准適應症高度重疊
- 有多個 RCT 和系統性回顧支持
- 藥理機轉明確
- 長期安全性資料完整
建議行動
- 這些適應症在臨床實務中已被廣泛使用
- 可考慮向 TFDA 申請適應症擴展（如明確的「十二指腸胃逆流」適應症）
- 持續監測長期使用的安全性
臨床建議
Famotidine 可安全用於：
- 輕至中度消化性潰瘍
- NSAID 相關潰瘍的預防
- 胃食道逆流疾病
- 應激性潰瘍預防
對於較嚴重的病例，可考慮使用 PPI 類藥物。
風險等級
低風險 - 可在適當適應症下安全使用
報告生成日期：2026-02-11 資料來源：TxGNN 預測、ClinicalTrials.gov、PubMed、TFDA
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引用本報告
如需引用本報告，請使用以下格式：
APA 格式：
TwTxGNN. (2026). Famotidine老藥新用驗證報告. https://twtxgnn.yao.care/drugs/famotidine/
BibTeX 格式：
@misc{twtxgnn_famotidine,
title = {Famotidine老藥新用驗證報告},
author = {TwTxGNN Team},
year = {2026},
url = {https://twtxgnn.yao.care/drugs/famotidine/}
}
免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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