Benzylpenicillin
證據等級: L5 | 預測適應症: 7 個
## 藥師評估報告
Benzylpenicillin：從一般細菌感染到牙冠周炎
一句話總結
Benzylpenicillin (青黴素 G) 是經典的 beta-lactam 抗生素，用於多種革蘭氏陽性菌感染，TxGNN 預測其對牙冠周炎有效，此預測獲得充分文獻支持。
快速總覽
| 項目 | 內容 | |------|------| | 原適應症 | 葡萄球菌、鏈球菌、肺炎球菌等革蘭氏陽性菌感染、梅毒、淋病、細菌性心內膜炎 | | 預測新適應症 | gingivitis、pericoronitis、gingival recession、canker sore、ulcerative stomatitis、denture stomatitis、chemotherapy-induced oral mucositis | | TxGNN 預測分數 | 99.36% | | 證據等級 | L3 (多篇觀察性研究和回顧性文獻) | | 台灣上市 | 已上市 | | 許可證數 | 多張 (注射劑型) | | 建議決策 | Go |
預測適應症詳細分析
1. pericoronitis L4 99.36% 主要分析
為什麼這個預測合理？
牙冠周炎是智齒萌出不全時周圍軟組織的感染，常見致病菌包括：
- 厭氧菌：Peptococcus, Peptostreptococcus, Bacteroides, Fusobacterium
- 需氧菌：Streptococcus 等
Penicillins (包括 benzylpenicillin 及其口服衍生物) 對這些病原菌有效，是口腔感染的一線抗生素選擇。
臨床試驗
目前無針對此特定適應症的臨床試驗登記。
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 36268928 | 2022 | Article | European journal of translatio | Antibiotic use in endodontic treatment during pregnancy: A narrative review. |
| 1873287 | 1991 | Article | The British journal of oral & | British oral and maxillofacial surgeons' views on the aetiology and management o... |
| 26067725 | 2015 | Article | The journal of contemporary de | Odontogenic Infections: A 1-year Retrospective Study. |
| 39068391 | 2024 | Article | BMC oral health | Assessment of a combined mouthwash on pain relief in pericoronitis: a randomized... |
| 29693642 | 2018 | Article | Antibiotics (Basel, Switzerlan | Antibiotic Prescribing for Oro-Facial Infections in the Paediatric Outpatient: A... |
| 12789143 | 2003 | Article | Oral surgery, oral medicine, o | Microbiology of mandibular third molar pericoronitis: incidence of beta-lactamas... |
| 35959239 | 2022 | Article | JAC-antimicrobial resistance | Indications for the use of metronidazole in the treatment of non-periodontal den... |
| 8126911 | 1994 | Article | Nihon rinsho. Japanese journal | [Chronic osteomyelitis of mandibulae]. |
| 40381916 | 2025 | Article | Journal of infection and chemo | Antimicrobial susceptibility surveillance of bacterial isolates recovered in Jap... |
| 16781343 | 2006 | Article | Journal of oral and maxillofac | Severe odontogenic infections, part 1: prospective report. |
| 25881243 | 2015 | Article | BMC microbiology | Characteristics of pyogenic odontogenic infection in patients attending Mulago H... |
| 4993797 | 1970 | Article | British dental journal | An allergic-type response. |
| 16388299 | 2006 | Article | Medicina oral, patologia oral | Antibiotic susceptibility of the bacteria causing odontogenic infections. |
| 12572406 | 2002 | Article | The Journal of the Tennessee D | Management of complex multi-space odontogenic infections. |
| 21027620 | 1946 | Article | American journal of orthodonti | Submaxillary abscess due to acute pericoronitis treated by aspiration and instil... |
| 11077383 | 2000 | Article | Oral surgery, oral medicine, o | Bacteriologic features and antimicrobial susceptibility in isolates from orofaci... |
| 32591324 | 2020 | Article | Journal of infection and chemo | Antimicrobial susceptibility surveillance of bacterial isolates recovered in Jap... |
| 4218248 | 1973 | Article | Journal of dentistry | The ectopic mandibular second molar. |
| 11406759 | 2001 | Article | Journal of infection and chemo | Incidence of deep fascial space infection after surgical removal of the mandibul... |
| 10870281 | 2000 | Article | British dental journal | A study of therapeutic antibiotic prescribing in National Health Service general... |
2. gingival recession L2 99.31%
臨床試驗（5 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT03692819 | NA | COMPLETED | 45 | Effect of Antibiotic and Probiotic Therapies in the Adjuvant Treatment of Chroni... |
| NCT05916742 | NA | UNKNOWN | 75 | Functionalization of a Volume-stable Collagen Matrix (VCMX) Using Injectable Pla... |
| NCT02922075 | PHASE4 | COMPLETED | 24 | Soft and Hard Tissue Stability After Immediate Tooth Replacement With Implant in... |
| NCT05916716 | NA | UNKNOWN | 50 | Use of a Novel Volume-stable Collagen Matrix (VCMX) in the Treatment of Single G... |
| NCT07233733 | NA | COMPLETED | 17 | Efficacy of Connective Tissue Graft Wall Technique and Enamel Matrix Derivative ... |
相關文獻（19 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 31938962 | 2020 | Article | Clinical oral investigations | Gingival recession after scaling and root planing with or without systemic metro... |
| 38699828 | 2024 | Article | Journal of clinical periodonto | Systemic antibiotics in the surgical treatment of peri-implantitis: A randomized... |
| 40843516 | 2025 | Article | Dental and medical problems | Early healing after regenerative periodontal surgery with or without antibiotics... |
| 30076615 | 2018 | Article | Journal of clinical periodonto | Clinical and microbiological effects of scaling and root planing, metronidazole ... |
| 36050890 | 2022 | Article | Journal of periodontal researc | Smoking negatively impacts the clinical, microbiological, and immunological trea... |
| 25734716 | 2015 | Article | The International journal of p | Efficacy of the lateral advanced flap in root-coverage procedures for mandibular... |
| 22288485 | 2012 | Article | Journal of periodontology | The combination of amoxicillin and metronidazole improves clinical and microbiol... |
| 26345106 | 2016 | Article | Quintessence international (Be | Amoxicillin/metronidazole associated with nonsurgical therapy did not promote ad... |
| 8682922 | 1995 | Article | Journal of clinical periodonto | Guided tissue regeneration in the treatment of degree II furcations in maxillary... |
| 10225539 | 1999 | Article | Journal of periodontology | Topical and systemic antimicrobial therapy in guided tissue regeneration. |
| 19254119 | 2009 | Article | Journal of periodontology | Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root plani... |
| 10225541 | 1999 | Article | Journal of periodontology | Comparison of enamel matrix proteins and bioabsorbable membranes in the treatmen... |
| 28944351 | 2017 | Article | Oral health & preventive denti | The Effect of Nonsurgical Periodontal Therapy on the Level of Human Neutrophil P... |
| 26457620 | 2015 | Article | Journal of clinical orthodonti | Interdisciplinary management of aggressive periodontitis. |
| 11288792 | 2001 | Article | Journal of periodontology | The effect of postsurgical antibiotics on the healing of intrabony defects follo... |
| 24493231 | 2014 | Article | Clinical oral investigations | Six-month results following treatment of aggressive periodontitis with antimicro... |
| 27084855 | 2016 | Article | The journal of contemporary de | Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided ... |
| 22873656 | 2013 | Article | Journal of periodontology | Are there specific benefits of amoxicillin plus metronidazole in Aggregatibacter... |
| 23836044 | 2013 | Article | Schweizer Monatsschrift fur Za | Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or s... |
3. canker sore L3 99.27%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT02750800 | N/A | COMPLETED | 427 | Post-marketing Observational Study to Evaluate the Effect of HUMIRA (Adalimumab)... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 25587367 | 2014 | Article | GMS current topics in otorhino | Tonsillitis and sore throat in children. |
| 24710788 | 2014 | Article | Laryngo- rhino- otologie | [Tonsillitis and sore throat in childhood]. |
| 35744034 | 2022 | Article | Medicina (Kaunas, Lithuania) | Efficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Me... |
| 5025246 | 1972 | Article | South African medical journal | Cancrum oris. |
| 11072515 | 2000 | Article | Nederlands tijdschrift voor ge | [Stomatitis in childhood, not always benign]. |
| 12731633 | 2003 | Article | The Annals of otology, rhinolo | Update on treatment of Marshall's syndrome (PFAPA syndrome): report of five case... |
| 14676759 | 2003 | Article | Oral surgery, oral medicine, o | The efficacy and safety of 50 mg penicillin G potassium troches for recurrent ap... |
| 20249827 | 1946 | Article | Schweizerische Monatsschrift f | [Ulcerative gingivostomatitis and penicillin]. |
| 33273940 | 2020 | Article | Journal of research in medical | Penicillin in oral aphthosis, new insight for an old drug: A randomized, double-... |
| 20188604 | 2010 | Article | Oral surgery, oral medicine, o | Evaluation of penicillin G potassium troches in the treatment of minor recurrent... |
| 22306278 | 2013 | Article | Allergologia et immunopatholog | Clinical Stevens-Johnson syndrome and rufinamide: a clinical case. |
| 10945185 | 2000 | Article | International dental journal | Grievances in cases using antibiotics due to orodental problems and assessment o... |
| 1254999 | 1976 | Article | The Journal of laryngology and | Treatment of superficial lesions of the mouth and pharynx. |
| 8322052 | 1993 | Article | Schweizerische medizinische Wo | [Cervical abscess caused by Capnocytophaga ochracea]. |
| 14225295 | 1964 | Article | Journal de medecine et de chir | [USE OF AMPICILLIN IN PEDIATRICS]. |
| 5787926 | 1969 | Article | Minerva medica | [Clinical study of methampicillin in pediatrics]. |
| 25604539 | 2015 | Article | HNO | [Multiple aphthous lesions of the oral mucosa]. |
| 13048907 | 1951 | Article | Stomatologiia. Stomatology | [Treatment of ulcerative stomatitis with penicillin candy]. |
| 15431713 | 1950 | Article | Zahnarztliche Rundschau | [Experiences with local application of sulfonamides and vitamin C in ulcerating ... |
| 15442746 | 1950 | Article | Stomatologiia | [Treatment of acute forms of ulcerative stomatitis with penicillin]. |
4. ulcerative stomatitis L3 99.26%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT02750800 | N/A | COMPLETED | 427 | Post-marketing Observational Study to Evaluate the Effect of HUMIRA (Adalimumab)... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 36268928 | 2022 | Article | European journal of translatio | Antibiotic use in endodontic treatment during pregnancy: A narrative review. |
| 20249827 | 1946 | Article | Schweizerische Monatsschrift f | [Ulcerative gingivostomatitis and penicillin]. |
| 5303184 | 1968 | Article | Bulletin / Monmouth-Ocean Coun | Acute necrotizing ulcerative gingivitis (ANUG: diagnosis and therapy). |
| 1900721 | 1991 | Article | The British journal of oral & | Cancrum oris-like lesions. |
| 70724 | 1977 | Article | Lancet (London, England) | Mismanaged facial infection. |
| 5233641 | 1967 | Article | Nederlands tijdschrift voor ta | [Ulcerative gingivitis]. |
| 4376235 | 1974 | Article | The Practitioner | Virus diseases. |
| 10522213 | 1999 | Article | Oral diseases | Microbiological understandings and mysteries of noma (cancrum oris). |
| 14118940 | 1964 | Article | Medical science | VINCENT'S INFECTION. |
| 29693642 | 2018 | Article | Antibiotics (Basel, Switzerlan | Antibiotic Prescribing for Oro-Facial Infections in the Paediatric Outpatient: A... |
| 27793616 | 2016 | Article | Digestive and liver disease : | Concomitant hidradenitis suppurativa and pyostomatitis vegetans in silent ulcera... |
| 20240622 | 1947 | Article | Schweizerische Monatsschrift f | [Treatment of Plaut-Vincentian infection and ulcerative stomatitis with penicill... |
| 20251770 | 1947 | Article | Arztliche Wochenschrift | [Successful treatment of severe stomatitis and ulcerative gingivitis with penici... |
| 167362 | 1975 | Article | The Practitioner | Healthy and diseased gingiva. |
| 5957282 | 1966 | Article | Journal of oral therapeutics a | Acute necrotizing ulcerative gingivitis. |
| 21004605 | 1945 | Article | British dental journal | A case of ulcerative stomatitis treated with penicillin. |
| 7316264 | 1981 | Article | Annals of emergency medicine | Acute necrotizing ulcerative tonsillitis and gingivitis (Vincent's infections). |
| 12655218 | 2003 | Article | Plastic and reconstructive sur | A history of noma, the "Face of Poverty". |
| 20283657 | 1947 | Article | South African dental journal. | The treatment of Vincent's with penicillin. |
| 20287945 | 1947 | Article | Journal of the American Dental | Penicillin in the treatment of Vincent's infection. |
5. denture stomatitis L4 99.26%
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 36441017 | 2022 | Article | Medical mycology | A novel rat model of denture stomatitis and the role of antibiotics in the devel... |
| 38287486 | 2024 | Article | Oral diseases | Cryptocarya moschata extract decreases single and mixed biofilms on acrylic resi... |
| 4147582 | 1973 | Article | The Journal of prosthetic dent | Microbiologic studies on denture stomatitis. |
6. chemotherapy-induced oral mucositis L4 99.26%
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 8668968 | 1996 | Article | Schweizerische medizinische Wo | [Skin and hair]. |
| 37645542 | 2023 | Article | IDCases | Lachnoanaerobaculum orale bacteremia in a patient with acute myeloid leukemia an... |
| 41328851 | 2025 | Article | The Medical journal of Malaysi | Incidence and clinical patterns, severity and preventability of cutaneous advers... |
7. leukoplakia of gingiva L5 99.06%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
台灣上市資訊
| 許可證號 | 中文品名 | 劑型 | 許可證持有者 | 效期 | |----------|----------|------|--------------|------| | (多張許可證) | 博西林注四十萬單位等 | 注射劑 | 多家藥廠 | 依各許可證 |
註： Benzylpenicillin 主要為注射劑型，口腔感染通常使用其口服衍生物如 phenoxymethylpenicillin (penicillin V) 或 amoxicillin。
安全性考量
- 過敏反應：青黴素類過敏史為絕對禁忌
- 交叉過敏：與其他 beta-lactam 類藥物可能有交叉反應
- 抗藥性考量：部分口腔菌株產生 beta-lactamase，可能需要合併使用 beta-lactamase 抑制劑或改用 amoxicillin-clavulanate
- 腎功能不全：需調整劑量
藥物-疾病注意事項 (DDSI)
資料來源：DDInter 2.0（原文內容請參閱該網站）
氣喘 🟡 Moderate
- 應謹慎使用本藥物。
Colitis 🟢 Minor
- 風險包括：感染。可能有致命風險。
結論與下一步
決策：Go 理由： TxGNN 的預測獲得充分的文獻和臨床實務支持。Penicillins 類藥物已是口腔感染（包括牙冠周炎）的一線抗生素選擇。台灣臨床實務中，amoxicillin 是更常用的口服選擇，benzylpenicillin 則用於需要注射給藥的嚴重感染。 若要推進需要：
- 臨床上優先考慮口服 amoxicillin 或 penicillin V，而非注射型 benzylpenicillin
- 對於嚴重牙冠周炎合併蜂窩性組織炎，可考慮注射型 benzylpenicillin
- 考慮合併 metronidazole 以涵蓋厭氧菌
- 注意青黴素過敏病史，必要時改用 clindamycin 或 azithromycin
- 此預測更多確認現有實務，而非提出新的治療方向
相關藥物報告
- Alirocumab - 證據等級 L5
- Benazepril - 證據等級 L5
- Nitrofurantoin - 證據等級 L5
- Travoprost - 證據等級 L5
- Warfarin Af - 證據等級 L5
用 AI 幫我深入分析
想進一步了解這個藥物的老藥新用潛力嗎？點擊下方按鈕，直接開啟 AI 助手進行分析。
Claude：點擊後會複製提問並開啟新視窗，請按 Ctrl+V（Mac: Cmd+V）貼上
ChatGPT：點擊後直接開啟並自動帶入提問
引用本報告
如需引用本報告，請使用以下格式：
APA 格式：
TwTxGNN. (2026). Benzylpenicillin老藥新用驗證報告. https://twtxgnn.yao.care/drugs/benzylpenicillin/
BibTeX 格式：
@misc{twtxgnn_benzylpenicillin,
title = {Benzylpenicillin老藥新用驗證報告},
author = {TwTxGNN Team},
year = {2026},
url = {https://twtxgnn.yao.care/drugs/benzylpenicillin/}
}
免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
歡迎分享您對本報告的看法、補充資訊或提出問題。討論內容會同步到 GitHub Discussions。 需要 GitHub 帳號才能留言。