Terbutaline
證據等級: L5 | 預測適應症: 3 個
## 藥師評估報告
Terbutaline 藥師筆記
一句話總結
Terbutaline（特必林）是選擇性 beta-2 腎上腺素受體促效劑，TxGNN 預測其對阻塞性肺病具療效，已有大量臨床試驗證據支持。
快速總覽
| 項目 | 內容 |
|---|---|
| 藥物名稱 | Terbutaline |
| DrugBank ID | DB00871 |
| 台灣商品名 | 喘克注射液、特必林錠、布乃可錠等 |
| 原核准適應症 | 支氣管性氣喘、支氣管炎、肺氣腫 |
| 預測新適應症 | bronchitis、dry eye syndrome、obstructive lung disease |
| 最高證據等級 | L1（多個 RCT） |
| TxGNN 分數 | 0.892（阻塞性肺病） |
預測適應症詳細分析
1. obstructive lung disease L1 99.96% 主要分析
為什麼這個預測合理？
### 作用機轉支持
Terbutaline 選擇性作用於 beta-2 腎上腺素受體，造成支氣管平滑肌鬆弛，擴張氣道。此機轉對所有阻塞性呼吸道疾病（包括氣喘、COPD、慢性支氣管炎）均有效。
臨床試驗
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT04433104 | PHASE1, PHASE2 | COMPLETED | 40 | Allogeneic Human Umbilical Cord-derived Mesenchymal Stem/Stromal Cells for Chron... |
| NCT00668408 | PHASE4 | UNKNOWN | 1000 | Long-Term Oxygen Therapy (LTOT) in Chronic Obstructive Pulmonary Disease (COPD) ... |
| NCT00244608 | PHASE3 | COMPLETED | 100 | A Comparison of the Inflammatory Control of Asthma Provided by One Inhalation of... |
| NCT04835961 | N/A | COMPLETED | 1037 | This Study Will Record the Use of Budesonide / Formoterol Either as Maintenance ... |
| NCT02504801 | PHASE4 | UNKNOWN | 73 | Efficacy of Nebulized Pulmicort Respules on Post Operation Pulmonary Complicatio... |
| NCT03611777 | N/A | COMPLETED | 901 | Non-interventional, Cross-sectional, Multicenter Study to Describe the Exacerbat... |
| NCT02509299 | NA | COMPLETED | 49 | Effect of Different Physiotherapy Treatments in Hospitalized COPD Patients |
| NCT01096017 | PHASE3 | COMPLETED | 24 | A Study to Investigate the Relative Efficacy of Terbutaline Turbuhaler® 0.4 mg a... |
| NCT03219736 | NA | WITHDRAWN | 0 | A Randomized Controlled Trial of Non-Invasive Positive Airway Pressure in the Pe... |
| NCT02515318 | NA | UNKNOWN | 60 | Effects of a Physiotherapy Program in Acute Exacerbation of Chronic Obstructive ... |
| NCT06373692 | N/A | NOT_YET_RECRUITING | 1508 | REspiratory diSEAse cohoRt Studies of CHinese Medicine for Asthma (RESEARCH- Ast... |
| NCT00326053 | PHASE3 | COMPLETED | 600 | A Comparison of Budesonide/Formoterol Turbuhaler® 160/4.5 µg 2 Inhalations BID P... |
| NCT00839800 | PHASE3 | COMPLETED | 2091 | A Comparison of Symbicort® SMART (160/4.5μg) and Symbicort® Turbuhaler 160/4.5 μ... |
| NCT01729351 | N/A | COMPLETED | 7195 | Comparative Effectiveness of Extrafine Hydrofluoroalkane Beclometasone Versus Fl... |
| NCT05841901 | NA | UNKNOWN | 224 | Evaluation of the Efficacy and Mechanism of Action of Huang-long Zhi-xiao Granul... |
| NCT00242775 | PHASE3 | COMPLETED | 2100 | Efficacy and Safety of Symbicort ®Turbuhaler® 160/4.5 µg/Inhalation, Two Inhalat... |
| NCT02494076 | PHASE4 | COMPLETED | 52 | Positive Expiratory Pressure for the Treatment of Acute Asthma Exacerbations in ... |
| NCT00531791 | PHASE3 | COMPLETED | 14 | Effects of Fluticasone/Salmeterol (Advair®) in Outpatients With Chronic Obstruct... |
| NCT02790047 | NA | UNKNOWN | 50 | Effect of Home-base Exercise Program With a Conical Positive Expiratory Pressure... |
| NCT00914797 | PHASE4 | UNKNOWN | 30 | Blood and Urinary Concentrations of Terbutaline in Asthmatics and Elite Athletes... |
| NCT00567476 | PHASE4 | COMPLETED | 116 | A Randomized, Open-label, Multicenter Study to Evaluate the Effect of Xolair (Om... |
| NCT01287351 | N/A | COMPLETED | 82903 | Retrospective, Real-life Observational Evaluation of the Effectiveness and Cost-... |
| NCT05853809 | NA | UNKNOWN | 3000 | Clinical Effect of FeNO Measurement for Asthma Treatment in Primary Care: A Real... |
| NCT00837967 | PHASE3 | COMPLETED | 25 | A Comparison of Tolerability of 10 Inhalations of Symbicort® Turbuhaler® 160/4.5... |
| NCT01136421 | PHASE3 | COMPLETED | 124 | Magnesium Sulfate Versus Ipratropuim Bromide in Acute Exacerbation of Chronic Ob... |
| NCT01141465 | N/A | COMPLETED | 815377 | A Retrospective Evaluation of the Effectiveness of Fixed-dose Combination Inhale... |
| NCT06626620 | PHASE3 | COMPLETED | 120 | Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline ... |
| NCT04016220 | PHASE1 | UNKNOWN | 60 | Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthm... |
| NCT02103374 | PHASE4 | COMPLETED | 45 | Evaluation of Benefit of Nebulized Bronchodilators at Home in Severe Chronic Obs... |
| NCT00849095 | PHASE3 | COMPLETED | 860 | As Needed Budesonide/Formoterol Combination Versus Regular Budesonide/Formoterol... |
| NCT00750568 | N/A | UNKNOWN | 36 | Pharmacokinetics and Pharmacodynamics of Terbutaline Given as a Continuous Intra... |
| NCT00628758 | PHASE3 | COMPLETED | 430 | A Comparison of Symbicort® Single Inhaler Therapy (Symbicort Turbuhaler® 160/4.5... |
| NCT04973345 | PHASE2, PHASE3 | WITHDRAWN | 0 | A Prospective, Blinded, Cross-Over Trial of the Exposure-Response Relationship o... |
| NCT06097507 | NA | COMPLETED | 54 | Patient and Prescriber Perspective on Climate Impact of Inhalers in the Treatmen... |
| NCT02048930 | N/A | COMPLETED | 24003 | Effectiveness and Cost-effectiveness Evaluation of Easyhaler Versus Other Device... |
| NCT05166811 | PHASE2 | COMPLETED | 52 | Intravenous Magnesium: Prompt Use for Asthma in Children Treated in the Emergenc... |
| NCT02224157 | PHASE3 | COMPLETED | 4215 | A Clinical Study Comparing Symbicort 'as Needed' With Pulmicort Twice Daily Plus... |
| NCT02149199 | PHASE3 | COMPLETED | 3850 | A Clinical Study Comparing Symbicort® 'as Needed' With Terbutaline 'as Needed' a... |
| NCT01944033 | PHASE3 | COMPLETED | 250 | β2-agonist Versus Ipratropium Bromide Associated With β2-agonists in Chronic Obs... |
| NCT01400217 | N/A | COMPLETED | 56985 | HFA Beclomethasone in Asthma, a General Practice Research Database Study: Real-l... |
| NCT00259766 | PHASE3 | COMPLETED | 1970 | Symbicort and Health Economics in a Real Life Evaluation - SHARE - A Randomised,... |
| NCT01877954 | N/A | COMPLETED | 2654 | Comparative Effectiveness of Extrafine Hydrofluoroalkane Beclometasone Versus Fl... |
| NCT02322788 | PHASE3 | COMPLETED | 95 | A Randomised, Double-blind, Double-dummy, Multi-site, Phase III, Single Dose, 4-... |
| NCT00421122 | PHASE3 | COMPLETED | 315 | A 6-Month, Phase IIIA, Multi-Center,Randomised,Double-Blind, Double-Dummy, Paral... |
| NCT01141439 | N/A | COMPLETED | 815377 | A Retrospective Evaluation of the Effectiveness and Cost-effectiveness of HFA-BD... |
| NCT01908075 | N/A | COMPLETED | 194723 | REACH Fostair vs Seretide - Real-world Effectiveness of Combination Therapies in... |
| NCT00252863 | PHASE3 | COMPLETED | 1600 | A Comparison of Symbicort Single Inhaler Therapy (Symbicort Turbuhaler 160/4.5 µ... |
| NCT02140684 | N/A | SUSPENDED | 400 | Exhaled Nitric Oxide in Asthma Management: a Retrospective Real-life Observation... |
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 30227794 | 2018 | Article | Praxis | [Not Available]. |
| 6417212 | 1983 | Article | The Journal of allergy and cli | Asthma in childhood. |
| 30156361 | 2019 | Article | Academic emergency medicine : | Nebulized Terbutaline and Ipratropium Bromide Versus Terbutaline Alone in Acute ... |
| 6107217 | 1980 | Article | Chest | Beta-adrenoceptor blockers and terbutaline in patients with chronic obstructive ... |
| 33065789 | 2020 | Article | Annals of palliative medicine | Clinical value of N-acetylcysteine combined with terbutaline sulfate in elderly ... |
| 3073804 | 1988 | Article | British journal of diseases of | Terbutaline and diaphragm function in chronic obstructive pulmonary disease: a d... |
| 18761816 | 2008 | Article | Cellular & molecular immunolog | Atomization inhalation of terbutaline and budesonide efficiently improved immuni... |
| 20004090 | 2010 | Article | Respiratory medicine | Emitted dose and lung deposition of inhaled terbutaline from Turbuhaler at diffe... |
| 36227333 | 2023 | Article | Naunyn-Schmiedeberg's archives | Clinical pharmacokinetics of terbutaline in humans: a systematic review. |
| 6988343 | 1980 | Article | International journal of clini | Oral NAB 365 (clenbuterol) and terbutaline in chronic obstructive lung disease: ... |
| 1745198 | 1991 | Article | The Medical journal of Austral | Bricanyl overdose. |
| 4606289 | 1974 | Article | Clinical pharmacology and ther | Bronchodilator effects of terbutaline and epinephrine in obstructive lung diseas... |
| 1615190 | 1992 | Article | Respiratory medicine | The effect of inhaled terbutaline on FEV1, FVC, dyspnoea and walking distance in... |
| 2951811 | 1986 | Article | Respiration; international rev | Acute on chronic comparative effects of a combination of fenoterol-ipratropium b... |
| 27512880 | 2016 | Article | Medicine | Modeling the effectiveness of nebulized terbutaline for decompensated chronic ob... |
| 10384064 | 1999 | Article | Lung | Effect of terbutaline on exercise capacity and pulmonary function in patients wi... |
| 2870630 | 1985 | Article | Allergologia et immunopatholog | Bronchodilator effects of terbutaline and theophylline alone and in combination ... |
| 6767605 | 1980 | Article | Equine veterinary journal | Chronic obstructive pulmonary disease (COPD): effects of bronchodilator drugs on... |
| 2805868 | 1989 | Article | Chest | Ventilation-perfusion distributions and central hemodynamics in chronic obstruct... |
| 3044105 | 1988 | Article | The American journal of the me | Oral terbutaline augments cardiac performance in chronic obstructive pulmonary d... |
2. respiratory malformation L3 99.52%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00220259 | NA | COMPLETED | 240 | Cystic Fibrosis Withdrawal of Inhaled Steroids Evaluation Study (CF WISE Study) |
| NCT04278404 | N/A | RECRUITING | 5000 | Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs |
相關文獻（12 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 19793774 | 2009 | Article | Toxicology and industrial heal | Do terbutaline- and mold-associated impairments of the brain and lung relate to ... |
| 1629507 | 1992 | Article | The Journal of allergy and cli | A comparative study of the effects of an inhaled corticosteroid, budesonide, and... |
| 3281307 | 1988 | Article | Thorax | Subcutaneous adrenaline versus terbutaline in the treatment of acute severe asth... |
| 9628312 | 1998 | Article | Acta paediatrica (Oslo, Norway | Multiple anomalies, hypokalaemic paralysis and partial symptomatic relief by ter... |
| 11813927 | 2001 | Article | Cardiology in the young | Use of terbutaline in the treatment of complete heart block in the fetus. |
| 2876923 | 1986 | Article | The Journal of international m | Tulobuterol in childhood asthma: single dose ranging and repeated oral dose comp... |
| 1620986 | 1992 | Article | Respiration; international rev | Analysis of respiratory impedance characteristics in chronic bronchitis. |
| 8947872 | 1996 | Article | Journal of veterinary internal | Bronchopulmonary disease in the cat: historical, physical, radiographic, clinico... |
| 8327281 | 1993 | Article | Pediatric pulmonology | A nonlinear regression analysis of nonlinear, passive-deflation flow-volume plot... |
| 19254906 | 2009 | Article | Archives of disease in childho | Budesonide improves decreased airway conductance in infants with respiratory sym... |
| 12061354 | 2002 | Article | Acta paediatrica (Oslo, Norway | Central airways stenosis in school-aged children: differential diagnosis from as... |
| 6314736 | 1983 | Article | Acta oto-laryngologica. Supple | Enhancement of ciliary action by a beta-adrenergic stimulant. |
3. Rienhoff syndrome L5 99.38%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
台灣上市資訊
已核准產品
| 許可證號 | 商品名 | 劑型 | 含量 |
|---|---|---|---|
| 衛署藥製字第041766號 | 喘克注射液 0.2mg/mL | 注射劑 | 0.2mg/mL |
| 衛署藥製字第026805號 | 特必林錠 2.5mg | 錠劑 | 2.5mg |
| 衛署藥製字第019714號 | 布乃可錠 2.5mg | 錠劑 | 2.5mg |
| 衛署藥製字第033582號 | 特必林液 | 口服液 | - |
健保給付狀態
所有劑型均有健保給付，屬於基本呼吸道用藥。
安全性考量
藥物交互作用
| 交互作用藥物 | 嚴重程度 | 說明 |
|---|---|---|
| Beta 阻斷劑 | 中度 | 拮抗作用，降低療效 |
| MAO 抑制劑 | 中度 | 可能增強心血管副作用 |
| 三環抗憂鬱劑 | 中度 | 可能增強心血管副作用 |
| 利尿劑 | 輕度 | 可能加重低血鉀 |
主要不良反應
- 常見：心悸、手抖、頭痛、肌肉痙攣
- 較少見：心律不整、低血鉀
- 罕見：過敏反應
特殊族群注意事項
- 心血管疾病：謹慎使用，監測心率
- 糖尿病：可能影響血糖控制
- 甲狀腺亢進：可能加重症狀
- 懷孕：Category B，曾用於安胎但有爭議
藥物-疾病注意事項 (DDSI)
資料來源：DDInter 2.0（原文內容請參閱該網站）
心血管疾病 🟡 Moderate
- 風險包括：心律不整。
糖尿病 🟡 Moderate
- 需定期監測。
Hypokalemia 🟡 Moderate
- 注意事項：Adrenergic bronchodilators may cause decreases in serum potassium concentrations, primarily when given by nebulization or intravenous administration…
Seizures 🟡 Moderate
- 風險包括：癲癇發作。
結論與下一步
預測可信度評估
| 預測適應症 | 證據等級 | 可信度 | 建議 |
|---|---|---|---|
| 阻塞性肺病（COPD） | L1 | 極高 | 已是成熟臨床實踐 |
臨床應用建議
- COPD 急性發作：可作為短效支氣管擴張劑使用
- COPD 維持治療：通常優先選用長效製劑（LABA），Terbutaline 作為備用
- 合併氣喘的 COPD：Terbutaline 特別適合
實務考量
Terbutaline 用於 COPD 雖非「新適應症」，但 TxGNN 的預測證實其臨床價值。在台灣，Terbutaline 主要適應症標示為氣喘和支氣管炎，若能明確納入 COPD 適應症，將使處方更為明確。
與其他藥物的定位比較
| 藥物類別 | 代表藥物 | 優勢 | 劣勢 |
|---|---|---|---|
| SABA（含 Terbutaline） | Terbutaline, Salbutamol | 快速起效、急救用 | 作用時間短 |
| LABA | Formoterol, Salmeterol | 作用時間長 | 起效較慢 |
| LAMA | Tiotropium | 24 小時作用 | 起效較慢 |
本筆記由 TxGNN 預測系統產生，僅供研究參考，不構成醫療建議。 更新日期：2026-02-11
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引用本報告
如需引用本報告，請使用以下格式：
APA 格式：
TwTxGNN. (2026). Terbutaline老藥新用驗證報告. https://twtxgnn.yao.care/drugs/terbutaline/
BibTeX 格式：
@misc{twtxgnn_terbutaline,
title = {Terbutaline老藥新用驗證報告},
author = {TwTxGNN Team},
year = {2026},
url = {https://twtxgnn.yao.care/drugs/terbutaline/}
}
免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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