Ouabain
證據等級: L5 | 預測適應症: 10 個
## 藥師評估報告
Ouabain 藥師筆記
一句話總結
Ouabain 為強心配醣體類藥物，TxGNN 預測其可能對鐮刀型紅血球貧血和心肌梗塞有治療潛力，但目前僅有前臨床研究支持，需謹慎評估其治療窗口極窄的安全性問題。
快速總覽
| 項目 | 內容 |
|---|---|
| 藥品名稱 | Ouabain (歐巴因) |
| DrugBank ID | DB01092 |
| 台灣商品名 | 安保心注射液 |
| 原適應症 | 心臟衰竭、心房撲動、心房纖維顫動、陣發性上室性心搏過速 |
| 預測新適應症 | Prinzmetal angina、hemoglobinopathy、myocardial infarction、thrombotic disease、hyperthyroidism、homozygous familial hypercholesterolemia、partial deletion of the short arm of chromosome 16、beta-thalassemia with other manifestations、brain small vessel disease 1 with or without ocular anomalies、autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome |
| 證據等級 | L4 (前臨床研究) |
| TxGNN 預測分數 | 0.995 (鐮刀型紅血球貧血)、0.994 (心肌梗塞) |
預測適應症詳細分析
1. Prinzmetal angina L5 99.69% 主要分析
2. hemoglobinopathy L4 99.48%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 1891492 | 1991 | Article | Planta medica | The in vitro effects of griffonin and ouabain on erythrocyte sodium content obta... |
| 3026473 | 1987 | Article | Biochimica et biophysica acta | Furosemide-sensitive Na+ and K+ transport and human erythrocyte volume. |
| 3034977 | 1987 | Article | The Journal of clinical invest | Sodium-potassium pump, ion fluxes, and cellular dehydration in sickle cell anemi... |
| 2947642 | 1987 | Article | Blood | The xerocytosis of Hb SC disease. |
| 3961486 | 1986 | Article | Science (New York, N.Y.) | Regulation of erythrocyte cation and water content in sickle cell anemia. |
| 3998150 | 1985 | Article | The Journal of clinical invest | Regulation of cation content and cell volume in hemoglobin erythrocytes from pat... |
| 9679176 | 1998 | Article | The Journal of physiology | Differential oxygen sensitivity of the K+-Cl- cotransporter in normal and sickle... |
| 4258090 | 1972 | Article | Archives of internal medicine | Pathological alterations of cation movements in red blood cells. |
| 10859357 | 2000 | Article | Proceedings of the National Ac | Identification and characterization of a newly recognized population of high-Na+... |
| 2430999 | 1986 | Article | The Journal of clinical invest | Cation depletion by the sodium pump in red cells with pathologic cation leaks. S... |
| 21209359 | 2011 | Article | American journal of physiology | Functional characterization and modified rescue of novel AE1 mutation R730C asso... |
| 2418897 | 1986 | Article | Blood | Calcium accumulated by sickle cell anemia red cells does not affect their potass... |
| 2810352 | 1989 | Article | The Journal of membrane biolog | Characteristics of the volume- and chloride-dependent K transport in human eryth... |
| 3699160 | 1986 | Article | FEBS letters | Volume-dependent and NEM-stimulated K+,Cl- transport is elevated in oxygenated S... |
| 8897817 | 1996 | Article | The American journal of physio | K(86Rb) transport heterogeneity in the low-density fraction of sickle cell anemi... |
| 2122921 | 1990 | Article | Blood | Permeability characteristics of deoxygenated sickle cells. |
| 16763000 | 2006 | Article | The Journal of physiology | Two different oxygen sensors regulate oxygen-sensitive K+ transport in crucian c... |
| 149799 | 1978 | Article | The Journal of clinical invest | Monovalent cation transport in irreversibly sickled cells. |
| 2213597 | 1990 | Article | The Journal of physiology | Deoxygenation permeabilizes sickle cell anaemia red cells to magnesium and rever... |
| 7204577 | 1981 | Article | The Journal of clinical invest | Increased erythrocyte cation permeability in thalassemia and conditions of marro... |
3. myocardial infarction L4 99.42%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 10564131 | 1999 | Article | The American journal of physio | Brain "ouabain" and angiotensin II contribute to cardiac dysfunction after myoca... |
| 99072 | 1977 | Article | Annals of clinical research | Pump failure in acute myocardial infarction. Fluid and drug therapy. |
| 767015 | 1976 | Article | Circulation | Effects of metabolic and pharmacologic interventions on myocardial infarct size ... |
| 19486591 | 2009 | Article | Current heart failure reports | The brain renin-angiotensin-aldosterone system: a major mechanism for sympatheti... |
| 19787147 | 2009 | Article | Brazilian journal of medical a | Ventricular performance and Na+-K+ ATPase activity are reduced early and late af... |
| 37775650 | 2023 | Article | Scientific reports | New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models. |
| 20029534 | 2009 | Article | Canadian journal of physiology | Brain renin-angiotensin-aldosterone system and ventricular remodeling after myoc... |
| 1090225 | 1975 | Article | Annals of internal medicine | Digitalis in acute myocardial infarction: help or hazard? |
| 5064781 | 1972 | Article | Anesthesia and analgesia | Myocardial function--1972. |
| 5557542 | 1971 | Article | British medical journal | Atrial fibrillation. II. |
| 30096873 | 2018 | Article | International journal of molec | Na/K-ATPase Signaling and Cardiac Pre/Postconditioning with Cardiotonic Steroids... |
| 5095927 | 1971 | Article | The American journal of cardio | Exit block. |
| 14693687 | 2004 | Article | American journal of physiology | Increases in brain and cardiac AT1 receptor and ACE densities after myocardial i... |
| 9315561 | 1997 | Article | Circulation | Blockade of brain 'ouabain' prevents the impairment of baroreflexes in rats afte... |
| 3973265 | 1985 | Article | Journal of the American Colleg | Enhancement of triggered activity in ischemic Purkinje fibers by ouabain: a mech... |
| 11489776 | 2001 | Article | Circulation | Heart failure after myocardial infarction: altered excitation-contraction coupli... |
| 36367691 | 2022 | Article | American journal of physiology | Whither digitalis? What we can still learn from cardiotonic steroids about heart... |
| 130383 | 1976 | Article | The Journal of clinical invest | Ischemia-induced alterations in myocardial (Na+ + K+)-ATPase and cardiac glycosi... |
| 6137280 | 1983 | Article | Cardiovascular clinics | Acute myocardial infarction--coronary thrombosis and salvage of the ischemic myo... |
| 1649699 | 1991 | Article | Cardiovascular research | Endogenous plasma Na,K-ATPase inhibitory activity and digoxin like immunoreactiv... |
4. thrombotic disease L4 99.33%
相關文獻（4 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 41118620 | 2025 | Article | Blood advances | The Na/K-ATPase Alpha-1 Subunit Fine-Tunes Platelet P2Y12 Function and Mediates ... |
| 6137280 | 1983 | Article | Cardiovascular clinics | Acute myocardial infarction--coronary thrombosis and salvage of the ischemic myo... |
| 1305429 | 1992 | Article | Eksperimental'naia i kliniches | [The increased sensitivity of rats to ouabain in the acute stage of heart failur... |
| 8324469 | 1993 | Article | Eksperimental'naia i kliniches | [The effect of ouabain on the cardiovascular system of rats with chronic heart f... |
5. hyperthyroidism L4 99.26%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 130826 | 1976 | Article | Annual review of physiology | Cellular thermogenesis. |
| 2168011 | 1990 | Article | Metabolism: clinical and exper | Erythrocyte sodium fluxes, ouabain binding sites, and Na+,K(+)-ATPase activity i... |
| 1324264 | 1992 | Article | Journal of endocrinological in | Na+K+ATPase activity and ouabain binding sites in erythrocytes in hyperthyroidis... |
| 2370297 | 1990 | Article | The Journal of clinical endocr | The effect of hyperthyroidism on in vivo aging of erythrocyte ouabain-binding si... |
| 4108576 | 1970 | Article | Klinische Wochenschrift | Serum concentration and urinary excretion of 3 H-ouabain and 3 H-digitoxin in pa... |
| 3011343 | 1986 | Article | Clinical physiology and bioche | Intracellular sodium concentration and transport in red cells in essential hyper... |
| 132454 | 1976 | Article | The Journal of clinical endocr | Alteration in intracellular sodium concentration and ouabain-sensitive ATPase in... |
| 12479229 | 2002 | Article | Basic research in cardiology | The cardiac sodium pump: structure and function. |
| 6825412 | 1983 | Article | Clinical science (London, Engl | Changes in the number and activity of sodium pumps in erythrocytes from patients... |
| 15171687 | 2004 | Article | The Journal of endocrinology | Activities of UDP-glucuronyltransferase, beta-glucuronidase and deiodinase types... |
| 862688 | 1977 | Article | Experimental neurology | Membrane electrical properties of fast- and slow-twitch muscles from rats with e... |
| 6090760 | 1984 | Article | Klinische Wochenschrift | Peripheral effects of thyroid hormones: alteration of intracellular Na-concentra... |
| 6281292 | 1982 | Article | The Journal of clinical endocr | Effect of thyroid status on ouabain binding to the human lymphocyte. |
| 3028698 | 1987 | Article | Clinical science (London, Engl | Ion flux and Na+,K+-ATPase activity of erythrocytes and leucocytes in thyroid di... |
| 3714451 | 1986 | Article | Pflugers Archiv : European jou | The effects of thyroid hormones on 3H-ouabain binding site concentration, Na,K-c... |
| 536921 | 1979 | Article | The Journal of physiology | Thyroid hormones and the energetics of active sodium-potassium transport in mamm... |
| 2746648 | 1989 | Article | Journal of molecular and cellu | Inter-species variations in myocardial responsiveness to cardiac glycosides: pos... |
| 1325595 | 1992 | Article | Metabolism: clinical and exper | Effects of fasting, refeeding, and fasting with T3 administration on Na-K,ATPase... |
| 6294446 | 1983 | Article | Metabolism: clinical and exper | Status of the red cell Na,K-pump in hyper- and hypothyroidism. |
| 11735082 | 2001 | Article | Metabolism: clinical and exper | Platelet Na,K-adenosine triphosphatase as a tissue marker of hyperthyroidism. |
6. homozygous familial hypercholesterolemia L5 99.19%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
7. partial deletion of the short arm of chromosome 16 L5 99.17%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
8. beta-thalassemia with other manifestations L5 99.17%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
9. brain small vessel disease 1 with or without ocular anomalies L4 99.17%
相關文獻（19 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35882526 | 2023 | Article | Journal of medical genetics | Axenfeld-Rieger syndrome: more than meets the eye. |
| 30182440 | 2018 | Article | American journal of medical ge | Neuropathology of holoprosencephaly. |
| 33870948 | 2022 | Article | Journal of neuro-ophthalmology | Optic Nerve Aplasia. |
| 11941259 | 2002 | Article | Journal francais d'ophtalmolog | [Congenital megalocornea]. |
| 6390155 | 1983 | Article | Neurologic clinics | Optic disk abnormalities. |
| 10498002 | 1999 | Article | Optometry and vision science : | Tilted disc syndrome. |
| 22963965 | 2012 | Article | Annales de dermatologie et de | [Branchio-oculo-facial syndrome]. |
| 1458324 | 1992 | Article | The Veterinary clinics of Nort | Congenital ocular anomalies. |
| 11581073 | 2001 | Article | Ophthalmology | Renal coloboma syndrome. |
| 406376 | 1977 | Article | Journal of pediatric ophthalmo | Peters-Rieger's syndrome. |
| 36636984 | 2023 | Article | Ophthalmic genetics | Congenital inner eyelid folds. |
| 2036354 | 1991 | Article | The British journal of ophthal | Ablepharon macrostomia syndrome. |
| 3050099 | 1988 | Article | Journal of medical genetics | The telecanthus-hypospadias syndrome. |
| 36926528 | 2023 | Article | Clinical ophthalmology (Auckla | Ophthalmological Manifestations of Axenfeld-Rieger Syndrome: Current Perspective... |
| 37468646 | 2024 | Article | Pediatric nephrology (Berlin, | Ocular manifestations of congenital anomalies of the kidney and urinary tract (C... |
| 35791156 | 2022 | Article | Indian journal of ophthalmolog | Clinical features and orbital anomalies in Fraser syndrome and a review of manag... |
| 16848213 | 2006 | Article | Acta medica Croatica : casopis | [Distichiasis]. |
| 30452766 | 2018 | Article | Journal of pediatric ophthalmo | Systemic Associations of Childhood Glaucoma: A Review. |
| 29133973 | 2017 | Article | Clinical ophthalmology (Auckla | Duane retraction syndrome: causes, effects and management strategies. |
10. autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome L5 99.15%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
台灣上市資訊
| 許可證字號 | 商品名 | 劑型 | 適應症 | 狀態 |
|---|---|---|---|---|
| 內衛藥製字第001934號 | 安保心注射液 | 注射劑 | 心臟衰竭、心房撲動、心房纖維顫動、陣發性上室性心博過速 | 有效 |
| 內衛藥製字第007192號 | 哇巴因注射液 | 注射劑 | 心臟衰竭、心房撲動 | 已註銷 |
| 衛署藥製字第033771號 | 吾安保因注射液 | 注射劑 | 心臟衰竭、心房撲動 | 已註銷 |
安全性考量
重要警語
- 治療窗口極窄：Ouabain 屬於強心配醣體，治療劑量與中毒劑量接近
- 心律不整風險：可能誘發嚴重心律不整，包括心室顫動
- 電解質監測：低血鉀會增加毒性風險，需密切監測電解質
藥物交互作用
目前資料庫中無記載重大藥物交互作用，但臨床上應注意：
- 利尿劑（可能導致低血鉀，增加毒性）
- 其他抗心律不整藥物
- 鈣離子補充劑
特殊族群
- 腎功能不全患者需調整劑量
- 老年人對強心配醣體更敏感
- 孕婦及哺乳婦女使用安全性未確立
結論與下一步
整體評估
Ouabain 對鐮刀型紅血球貧血和心肌梗塞的老藥新用預測在機轉上具有合理性，但：
- 證據等級偏低 (L4)：目前僅有基礎研究和動物實驗支持
- 安全性疑慮重大：治療窗口極窄，臨床應用風險高
- 臨床可行性有限：需要開發更安全的給藥方式或找到更安全的類似物
建議行動
- 不建議直接進行臨床試驗：需先進行更多前臨床安全性和有效性研究
- 探索替代策略：考慮研究其他 Na/K-ATPase 調節劑或開發 ouabain 衍生物
- 持續關注文獻：追蹤相關基礎研究進展
本報告由 TxGNN 預測系統生成，僅供研究參考，不構成醫療建議。
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引用本報告
如需引用本報告，請使用以下格式：
APA 格式：
TwTxGNN. (2026). Ouabain老藥新用驗證報告. https://twtxgnn.yao.care/drugs/ouabain/
BibTeX 格式：
@misc{twtxgnn_ouabain,
title = {Ouabain老藥新用驗證報告},
author = {TwTxGNN Team},
year = {2026},
url = {https://twtxgnn.yao.care/drugs/ouabain/}
}
免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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