Aluminum Hydroxide
證據等級: L3 | 預測適應症: 4 個
## 藥師評估報告
Aluminum Hydroxide：從胃酸過多到活動性消化性潰瘍
一句話總結
Aluminum hydroxide 原本用於緩解胃酸過多及胃部不適。 TxGNN 模型預測它可能對**活動性消化性潰瘍 (active peptic ulcer disease)** 有效， 目前有 **15 篇文獻**支持這個方向。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 胃酸過多、胃炎、胃及十二指腸潰瘍 |
| 預測新適應症 | 活動性消化性潰瘍 (active peptic ulcer disease) |
| TxGNN 預測分數 | 99.64% |
| 證據等級 | L3 |
| 台灣上市 | 有上市 |
| 許可證數 | 多張（含複方製劑） |
| 建議決策 | Proceed with Caution |
預測適應症詳細分析
1. active peptic ulcer disease L4 99.64% 主要分析
為什麼這個預測合理？
Aluminum hydroxide 是經典的制酸劑，透過中和胃酸來保護胃黏膜。其作用機轉包括：
- 中和胃酸：直接中和已分泌的胃酸，提升胃內 pH 值
- 抑制胃蛋白酶活性：在較高 pH 環境下，胃蛋白酶活性顯著降低
- 黏膜保護：研究顯示含鋁制酸劑具有胃黏膜保護作用
從原適應症（胃酸過多、胃炎）到預測適應症（活動性消化性潰瘍），
機轉上具有合理連結，皆涉及胃酸中和與黏膜保護。
臨床試驗
目前無針對此特定適應症的臨床試驗登記。
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 37146 | 1979 | Article | Fortschritte der Medizin | [Therapy with antacids]. |
| 22950493 | 2013 | Article | Current pharmaceutical design | Gastric cytoprotection beyond prostaglandins: cellular and molecular mechanisms ... |
| 7034155 | 1981 | Article | Scandinavian journal of gastro | Antacid/anticholinergic, cimetidine, and placebo in treatment of active peptic u... |
| 1769429 | 1991 | Article | Digestion | Intragastric pH in the gastroprotective and ulcer-healing activity of aluminum-c... |
| 2401189 | 1990 | Article | Drugs under experimental and c | Peptic disease in paediatric patients: a diagnostic and therapeutic contribution... |
| 6086186 | 1984 | Article | Clinics in gastroenterology | Antacids and anticholinergics in the treatment of duodenal ulcer. |
| 35720246 | 2022 | Article | Medicine and pharmacy reports | Evaluation of the acid-neutralizing capacity and other properties of antacids ma... |
| 2686073 | 1989 | Article | Terapevticheskii arkhiv | [The effect of almagel, gastrotsepin and food on the acidity and protease activi... |
| 6927335 | 1982 | Article | Pharmacotherapy | Pharmacology, clinical efficacy, and adverse effects of sucralfate, a nonsystemi... |
| 28164737 | 2017 | Article | Pharmaceutical biology | Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum see... |
| 31111054 | 2019 | Article | BioMed research international | Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats. |
| 3018068 | 1986 | Article | Journal of clinical gastroente | The effect of sodium bicarbonate versus aluminum-magnesium hydroxide on postpran... |
| 1526089 | 1992 | Article | Clinical pharmacology and ther | Nizatidine versus placebo in active benign gastric ulcer disease: an eight-week,... |
| 2986275 | 1985 | Article | Scandinavian journal of gastro | Sucralfate and alginate/antacid in reflux esophagitis. |
| 6798099 | 1981 | Article | Journal of clinical gastroente | Development and characteristics of sucralfate. |
| 2340961 | 1990 | Article | Digestion | Mucosal protective activity of activated aluminum complex. |
| 9334882 | 1997 | Article | Japanese journal of pharmacolo | Effects of sucralfate and its components on acid- and pepsin-induced damage to r... |
| 2390927 | 1990 | Article | Digestive diseases and science | Healing of chronic gastroduodenal ulcerations by antacids. Role of prostaglandin... |
| 9305482 | 1997 | Article | Alimentary pharmacology & ther | H2-receptor antagonists and antacids have an aggravating effect on Helicobacter ... |
| 2783181 | 1989 | Article | Arzneimittel-Forschung | Cytoprotective and antiulcer activities of the antacid magaldrate in the rat. |
2. gastroduodenitis L4 99.59%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 1769429 | 1991 | Article | Digestion | Intragastric pH in the gastroprotective and ulcer-healing activity of aluminum-c... |
| 38192 | 1979 | Article | Gut | Antacids and peptic ulcer--a reappraisal. |
| 18103089 | 1949 | Article | The Review of gastroenterology | Treatment of gastroduodenal peptic ulcers with protein hydrolysate and a non-rea... |
| 15401679 | 1949 | Article | Hospital (Rio de Janeiro, Braz | [Treatment of gastroduodenal ulcers by aluminum hydroxide jelly]. |
| 2205899 | 1990 | Article | Scandinavian journal of gastro | Antacids in gastric ulcer treatment: evidence of cytoprotection. |
| 28164737 | 2017 | Article | Pharmaceutical biology | Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum see... |
| 9061069 | 1996 | Article | Tumori | Sucralfate prophylaxis of fluorouracil-induced stomatitis. |
| 13956663 | 1962 | Article | Rassegna di fisiopatologia cli | [The prevention of cortisone-induced gastroduodenal ulcer by means of combined t... |
| 2390927 | 1990 | Article | Digestive diseases and science | Healing of chronic gastroduodenal ulcerations by antacids. Role of prostaglandin... |
| 1940188 | 1991 | Article | Journal of clinical gastroente | Morphologic and ultrastructural effects of Maalox TC on human gastric and duoden... |
| 1834730 | 1991 | Article | Journal of clinical gastroente | Efficacy of low-dose antacids in the treatment of peptic ulcers: pharmacological... |
| 3321397 | 1987 | Article | Scandinavian journal of gastro | Prophylactic treatment of acute gastroduodenal stress ulceration. Low-dose antac... |
| 1940189 | 1991 | Article | Journal of clinical gastroente | Low-dose antacids and nonsteroidal anti-inflammatory drug-induced gastropathy in... |
| 2598753 | 1989 | Article | Digestive diseases and science | Effect of antacid treatment on endogenous prostaglandin synthesis in human antra... |
| 8260735 | 1993 | Article | Journal of physiology and phar | New aspects of clinical pharmacology of antacids. |
| 4445556 | 1974 | Article | Revista espanola de las enferm | [Results obtained with Dogmagel in the treatment of gastroduodenal ulcer and gas... |
| 2041689 | 1991 | Article | Pediatriia | [Effects of reflexotherapy and drugs on the secretory function of the stomach in... |
| 8011006 | 1994 | Article | Arzneimittel-Forschung | Antacid activity of calcium carbonate and hydrotalcite tablets. Comparison betwe... |
| 2510618 | 1989 | Article | Annals of surgery | Misoprostol versus antacid titration for preventing stress ulcers in postoperati... |
| 1804328 | 1991 | Article | Revista de gastroenterologia d | [Uncomplicated peptic ulcer disease. The therapeutic prospects and practice]. |
3. gastrojejunal ulcer L4 99.54%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 4813464 | 1974 | Article | American family physician | Antacids. |
| 8641951 | 1996 | Article | Journal of the American Veteri | Effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicyla... |
| 20271751 | 1947 | Article | Archives of surgery (Chicago, | Aluminum hydroxide and magnesium trisilicate plus mucin in treatment of peptic u... |
| 20617595 | 1968 | Article | The New England journal of med | Acid rebound. |
| 15425465 | 1950 | Article | The American journal of digest | Aluminum hydroxide and magnesium trisilicate plus mucin in the treatment of 125 ... |
| 3891189 | 1985 | Article | Clinical pharmacology and ther | Effect of sucralfate and an aluminum hydroxide gel on gastric emptying of solids... |
| 6293043 | 1982 | Article | Scandinavian journal of gastro | Antacid therapy--changes in mineral metabolism. |
| 37146 | 1979 | Article | Fortschritte der Medizin | [Therapy with antacids]. |
| 2564832 | 1989 | Article | Gut | Are antacids cytoprotective? |
| 3608134 | 1987 | Article | Cleveland Clinic journal of me | Antacid-induced osteomalacia. |
| 4053915 | 1985 | Article | Digestive diseases and science | In vivo and in vitro evaluation of magnesium-aluminum hydroxide antacid tablets ... |
| 324863 | 1977 | Article | Gastroenterology | Controlled trials of aluminum hydroxide gels for peptic ulcer. |
| 1119360 | 1975 | Article | American family physician | Antacids. |
| 1769429 | 1991 | Article | Digestion | Intragastric pH in the gastroprotective and ulcer-healing activity of aluminum-c... |
| 22950493 | 2013 | Article | Current pharmaceutical design | Gastric cytoprotection beyond prostaglandins: cellular and molecular mechanisms ... |
| 38192 | 1979 | Article | Gut | Antacids and peptic ulcer--a reappraisal. |
| 10466876 | 1999 | Article | Scandinavian journal of gastro | Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion... |
| 1500660 | 1992 | Article | Journal of clinical gastroente | Calcium and acid rebound: a reappraisal. |
| 3940254 | 1986 | Article | Gastroenterology | Cimetidine blocks antacid-induced hypergastrinemia. |
| 6613216 | 1983 | Article | Zeitschrift fur Gastroenterolo | Absence of in vivo and in vitro interactions of an aluminum hydroxide, magnesium... |
4. peptic ulcer perforation L3 99.54%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00854776 | NA | UNKNOWN | 300 | The Occurrence of Peptic Ulcer Disease and Its Complications in Ischemic Heart P... |
台灣上市資訊
| 許可證號 | 品名 | 劑型 | 核准適應症 |
|---|---|---|---|
| 內衛藥製字第000373號 | 固胃必朗錠 | 錠劑 | 胃、十二指腸潰瘍、胃酸過多症、胃炎、胃痛 |
| 內衛藥製字第006937號 | 氫氧化鋁膠 | 粉劑 | 制酸劑 |
備註：多數含 Aluminum hydroxide 的製劑為複方製劑。
安全性考量
- 藥物交互作用：
- 重大交互作用：與 Dolutegravir（抗HIV藥物）併用會降低其吸收
- 中度交互作用：與 Acalabrutinib 併用需注意
- 輕微交互作用：與 Famotidine、Ranitidine、Acebutolol 等
- 長期使用注意事項：長期大量使用可能導致鋁蓄積，尤其在腎功能不全患者
藥物-疾病注意事項 (DDSI)
資料來源：DDInter 2.0（原文內容請參閱該網站）
Constipation 🟢 Minor
- 注意事項：Aluminum containing antacids may produce constipation, which may lead to intestinal obstruction…
藥物-食物交互作用 (DFI)
資料來源：DDInter 2.0（原文內容請參閱該網站）
柑橘類水果 🟢 Minor
- 影響：影響藥物吸收。可能增加藥物血中濃度。風險包括：毒性增加。
- 建議：建議分開服用。
汽水/碳酸飲料 🟢 Minor
- 影響：影響藥物吸收。可能增加藥物血中濃度。風險包括：毒性增加。
- 建議：建議分開服用。
結論與下一步
決策：Proceed with Caution
理由： Aluminum hydroxide 作為制酸劑用於消化性潰瘍有歷史文獻支持，但現代治療已有更有效的選擇（如 PPI、H2 阻斷劑）。預測適應症與原適應症重疊度高，可視為原適應症的延伸而非真正的老藥新用。
若要推進需要：
- 與現代標準治療的比較性研究
- 明確的給藥劑量與療程建議
- 長期安全性（特別是鋁蓄積）的評估
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引用本報告
如需引用本報告，請使用以下格式：
APA 格式：
TwTxGNN. (2026). Aluminum Hydroxide老藥新用驗證報告. https://twtxgnn.yao.care/drugs/aluminum_hydroxide/
BibTeX 格式：
@misc{twtxgnn_aluminum_hydroxide,
title = {Aluminum Hydroxide老藥新用驗證報告},
author = {TwTxGNN Team},
year = {2026},
url = {https://twtxgnn.yao.care/drugs/aluminum_hydroxide/}
}
免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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