Silicon Dioxide
證據等級: L4 | 預測適應症: 4 個
## 藥師評估報告
Silicon Dioxide：從賦形劑到消化性潰瘍探索
一句話總結
Silicon Dioxide（二氧化矽）主要作為藥品賦形劑及制酸劑使用。 TxGNN 模型預測它可能對**活動性消化性潰瘍 (Active Peptic Ulcer Disease)** 有效， 目前有 **12 篇文獻**支持這個方向，但缺乏直接臨床試驗的支持。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 賦形劑、制酸劑、胃酸過多、氣體吸著劑 |
| 預測新適應症 | Active Peptic Ulcer Disease（活動性消化性潰瘍） |
| TxGNN 預測分數 | 99.93% |
| 證據等級 | L4 |
| 台灣上市 | 已上市 |
| 許可證數 | 多張（含複方製劑） |
| 建議決策 | 可進一步探索 |
預測適應症詳細分析
1. active peptic ulcer disease L4 99.93% 主要分析
為什麼這個預測合理？
Silicon Dioxide 在醫藥領域主要作為賦形劑使用，但其矽酸鹽化合物已被用於胃腸道保護。
文獻顯示，矽酸類化合物可形成保護性屏障，增強黏膜保護功能。
TxGNN 預測的新適應症：
| 排名 | 預測適應症 | 預測分數 | TxGNN 排名 | 文獻數 |
|---|---|---|---|---|
| 1 | Active Peptic Ulcer Disease（活動性消化性潰瘍） | 99.93% | 1,971 | 12 篇 |
| 2 | Gastrojejunal Ulcer（胃空腸吻合處潰瘍） | 99.92% | 2,330 | 15 篇 |
活動性消化性潰瘍的預測具有合理的機轉基礎：
- 矽酸類制酸劑可中和胃酸、保護黏膜
- 中空介孔矽奈米粒子已被研究用於胃潰瘍藥物遞送系統
臨床試驗
目前無針對此特定適應症的臨床試驗登記。
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 2986275 | 1985 | Article | Scandinavian journal of gastro | Sucralfate and alginate/antacid in reflux esophagitis. |
| 7401102 | 1980 | Article | Journal of medicinal chemistry | Antiinflammatory effects of some copper complexes. |
| 6095236 | 1983 | Article | Polimery w medycynie | [Biological and pharmacological properties of orthosilicic acid and its derivati... |
| 315232 | 1979 | Article | Arzneimittel-Forschung | 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido [1,2-a] pyrimidine-3-carboxa... |
| 157060 | 1979 | Article | Agents and actions | Comparative effects of drugs on four paw oedema models in the rat. |
| 2877526 | 1986 | Article | Zeitschrift fur Gastroenterolo | [Therapeutic procedures in gastroesophageal reflux disease]. |
| 7612057 | 1995 | Article | Arzneimittel-Forschung | Synthesis and anti-inflammatory properties of 2-methyl-5-(3-phenylpropionyl)-1-b... |
| 1550303 | 1992 | Article | The American surgeon | Endoscopic intervention: a useful alternative to operation in the treatment of u... |
| 7173740 | 1982 | Article | Nihon yakurigaku zasshi. Folia | [Anti-edema activity of a trans-cutaneous non-steroidal anti-inflammatory agent,... |
| 7604597 | 1994 | Article | Likars'ka sprava | [The use of Smecta for the treatment of the basic digestive tract diseases]. |
| 5458923 | 1970 | Article | Therapie | [Study of anti-inflammatory and gastric anti-ulcerous activities of a steroid al... |
| 4615551 | 1974 | Article | Acta hepato-gastroenterologica | The effect of amylopectin sulfate (SN-263) on the peptic activity of human gastr... |
2. gastrojejunal ulcer L4 99.92%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 4312520 | 1970 | Article | British medical journal | Antacids. |
| 4220087 | 1974 | Article | Environmental health perspecti | Ingestion of asbestos. |
| 4359481 | 1974 | Article | The New England journal of med | Drug therapy. Antacid therapy. |
| 6293043 | 1982 | Article | Scandinavian journal of gastro | Antacid therapy--changes in mineral metabolism. |
| 32592251 | 2020 | Article | Alimentary pharmacology & ther | Editorial: simultaneous prolonged monitoring of the acid pocket and oesophageal ... |
| 39541155 | 2024 | Article | Nano letters | Antibiotic-Augmented Chemodynamic Therapy for Treatment of Helicobacter pylori I... |
| 2892083 | 1987 | Article | Lancet (London, England) | Carbenoxolone and hypokalaemia. |
| 32592257 | 2020 | Article | Alimentary pharmacology & ther | Editorial: simultaneous, prolonged monitoring of the acid pocket and oesophageal... |
| 6091079 | 1984 | Article | Postgraduate medical journal | Comparative study of four antacids. |
| 2986275 | 1985 | Article | Scandinavian journal of gastro | Sucralfate and alginate/antacid in reflux esophagitis. |
| 228924 | 1979 | Article | Drug and therapeutics bulletin | Pyrogastrone for oesophagitis. |
| 39103605 | 2025 | Article | Journal of general internal me | Risk of Serious Adverse Gastrointestinal Events with Potassium Binders in Hospit... |
| 38767185 | 2024 | Article | Advanced healthcare materials | Gastroretentive Raft Forming System for Enhancing Therapeutic Effect of Drug-Loa... |
| 11566 | 1976 | Article | The Surgical clinics of North | Medical management of bleeding duodenal ulcers. |
| 3888581 | 1985 | Article | Drug and therapeutics bulletin | Magaldrate and almasilate--complex buffering antacids. |
| 20271751 | 1947 | Article | Archives of surgery (Chicago, | Aluminum hydroxide and magnesium trisilicate plus mucin in treatment of peptic u... |
| 204058 | 1978 | Article | Southern medical journal | A multicentric, randomized clinical trial of Gaviscon in reflux esophagitis. |
| 5302464 | 1968 | Article | Japanese journal of pharmacolo | The effects of drugs on the production and recovery processes of the stress ulce... |
| 23329718 | 2013 | Article | BMJ case reports | Gaviscon: not always entirely safe! |
| 16927137 | 2006 | Article | Digestive diseases and science | Intravenous pantoprazole as initial treatment in patients with gastroesophageal ... |
3. peptic ulcer perforation L4 99.92%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 39103605 | 2025 | Article | Journal of general internal me | Risk of Serious Adverse Gastrointestinal Events with Potassium Binders in Hospit... |
4. gastric ulcer (disease) L4 99.83%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 4220087 | 1974 | Article | Environmental health perspecti | Ingestion of asbestos. |
| 4359481 | 1974 | Article | The New England journal of med | Drug therapy. Antacid therapy. |
| 39541155 | 2024 | Article | Nano letters | Antibiotic-Augmented Chemodynamic Therapy for Treatment of Helicobacter pylori I... |
| 38767185 | 2024 | Article | Advanced healthcare materials | Gastroretentive Raft Forming System for Enhancing Therapeutic Effect of Drug-Loa... |
| 5307474 | 1969 | Article | Japanese journal of pharmacolo | A new method for the production of chronic gastric ulcer in rats and the effect ... |
| 16927137 | 2006 | Article | Digestive diseases and science | Intravenous pantoprazole as initial treatment in patients with gastroesophageal ... |
| 11566 | 1976 | Article | The Surgical clinics of North | Medical management of bleeding duodenal ulcers. |
| 21767643 | 2011 | Article | European journal of pharmaceut | Incorporation of indomethacin nanoparticles into 3-D ordered macroporous silica ... |
| 26478311 | 2016 | Article | Materials science & engineerin | Control-release microcapsule of famotidine loaded biomimetic synthesized mesopor... |
| 5302464 | 1968 | Article | Japanese journal of pharmacolo | The effects of drugs on the production and recovery processes of the stress ulce... |
| 6782652 | 1980 | Article | Scandinavian journal of gastro | Intragastric PCO2 in man and calculated gastric bicarbonate concentrations: effe... |
| 164307 | 1975 | Article | Clinica chimica acta; internat | Studies on changes in lipid profiles of the rat gastric mucosa with stress ulcer... |
| 7401102 | 1980 | Article | Journal of medicinal chemistry | Antiinflammatory effects of some copper complexes. |
| 15688172 | 2005 | Article | Der Urologe. Ausg. A | [Silica-containing urinary stones--clinical issues to keep in mind]. |
| 1550303 | 1992 | Article | The American surgeon | Endoscopic intervention: a useful alternative to operation in the treatment of u... |
| 6547921 | 1984 | Article | Fortschritte der Medizin | [Changes in the transmural electric potential difference in the region of stomac... |
| 16335828 | 2005 | Article | Zhongguo Zhong yao za zhi = Zh | [The effect of muscovite on the quality of gastric ulcer healing]. |
| 157060 | 1979 | Article | Agents and actions | Comparative effects of drugs on four paw oedema models in the rat. |
| 2982563 | 1985 | Article | Deutsche medizinische Wochensc | [Therapy of stomach ulcer with low-dose antacid gel and cimetidine. A multicente... |
| 8050027 | 1993 | Article | Endoscopic surgery and allied | Water jet guided Nd:YAG laser coagulation--its application in the field of gastr... |
台灣上市資訊
| 許可證號 | 品名 | 劑型 | 核准適應症 | 狀態 |
|---|---|---|---|---|
| - | 息速坦腸溶糖衣錠100公絲 | 錠劑 | 急慢性支氣管炎、支氣管擴張症、感冒、副鼻腔炎之排膿 | - |
| - | 含 Silicon Dioxide 之複方制酸劑 | 多種 | 胃酸過多、胃灼熱、胃膨滿 | 有效 |
| - | 含 Silicon Dioxide 之賦形劑 | 粉/錠劑 | 賦形劑、製錠輔助劑 | 有效 |
（註：Silicon Dioxide 多作為複方成分或賦形劑使用）
安全性考量
- 一般安全性：
- 作為賦形劑使用時安全性良好
- 口服矽酸類制酸劑長期使用需監測電解質平衡
- 藥物交互作用：
- 無已知重大藥物交互作用
安全性資訊請參考原廠仿單。
結論與下一步
決策：可進一步探索
理由： TxGNN 預測的消化性潰瘍適應症與 Silicon Dioxide 相關化合物的制酸及黏膜保護作用機轉相符。 文獻顯示矽酸類化合物在胃腸道保護領域有應用潛力，且最新研究顯示中空介孔矽奈米粒子 可作為胃潰瘍藥物遞送的載體。
若要推進需要：
- 釐清 Silicon Dioxide 與含矽酸鹽制酸劑的作用差異
- 針對胃潰瘍保護作用的臨床前研究
- 探索矽奈米粒子作為藥物遞送載體的臨床可行性
- 評估長期口服安全性
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引用本報告
如需引用本報告，請使用以下格式：
APA 格式：
TwTxGNN. (2026). Silicon Dioxide老藥新用驗證報告. https://twtxgnn.yao.care/drugs/silicon_dioxide/
BibTeX 格式：
@misc{twtxgnn_silicon_dioxide,
title = {Silicon Dioxide老藥新用驗證報告},
author = {TwTxGNN Team},
year = {2026},
url = {https://twtxgnn.yao.care/drugs/silicon_dioxide/}
}
免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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