Vitamin E
證據等級: L3 | 預測適應症: 10 個
## 藥師評估報告
Vitamin E：從維生素缺乏症到膽紅素代謝疾病
一句話總結
Vitamin E 原本用於治療習慣性早流產、末梢血行障礙及維生素 E 缺乏症。 TxGNN 模型預測它可能對**先天性膽紅素代謝異常 (inborn disorder of bilirubin metabolism)** 有效， 目前有 **3 個臨床試驗**和 **2 篇文獻**支持這個方向。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 習慣性早流產、末梢血行障礙、維生素 E 缺乏症 |
| 預測新適應症 | benign recurrent intrahepatic cholestasis、familial intrahepatic cholestasis、inborn disorder of bilirubin metabolism、bilirubin metabolism disease、hereditary North American Indian childhood cirrhosis、drug-induced liver injury、microvillus inclusion disease、hyperbiliverdinemia、Navajo neurohepatopathy、nevus of Ito |
| TxGNN 預測分數 | 99.99% |
| 證據等級 | L3 |
| 台灣上市 | 已上市 |
| 許可證數 | 多張（多種劑型） |
| 建議決策 | Proceed with Caution |
預測適應症詳細分析
1. inborn disorder of bilirubin metabolism L3 99.99% 主要分析
為什麼這個預測合理？
Vitamin E 是重要的脂溶性抗氧化劑，可保護細胞膜免受氧化損傷。在膽汁淤積性肝病患者中，脂溶性維生素吸收不良常導致 Vitamin E 缺乏。研究顯示，早產兒補充 Vitamin E 可顯著降低血清膽紅素水平，減少光療需求。此外，Vitamin E 在慢性膽汁淤積性肝病中的補充已被證實對預防神經系統併發症有益。
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此預測基於藥物的作用機轉，與現有臨床證據方向一致。
臨床試驗
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01556906 | PHASE2 | COMPLETED | 6 | A Phase II Open Label, Dose-Escalation Study to Determine the Safety, Tolerabili... |
| NCT03115086 | N/A | ACTIVE_NOT_RECRUITING | 55 | A Prospective, Observational, Non-Interventional, Post-Marketing, Patient Regist... |
| NCT06465810 | N/A | RECRUITING | 1850 | A Non-interventional, Prospective, Multi-country Study Collecting Real-world Dat... |
相關文獻
2. bilirubin metabolism disease L1 99.99%
臨床試驗（27 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT04977661 | PHASE4 | COMPLETED | 102 | A Randomized Study to Compare the Efficacy of Vitamin E, Ursodeoxycholic Acid an... |
| NCT06382298 | NA | RECRUITING | 90 | Health Effects of Cottonseed Oil Versus Matched Composition Diets in Humans |
| NCT05686954 | NA | RECRUITING | 80 | Nutritional Effects of Different Doses of Cottonseed Oil in Humans |
| NCT05729659 | NA | COMPLETED | 30 | The Effect of Sideritis Scardica (SidTea+) Extract Supplementation on Health and... |
| NCT03864744 | N/A | UNKNOWN | 33 | Hepatic Histology and Metabolism Following Total Pancreatectomy and |
| NCT03121911 | NA | WITHDRAWN | 0 | Effects of Interval Physical Training on Inflammatory Markers, Cardiac Autonomic... |
| NCT04915014 | NA | UNKNOWN | 320 | Prospective Multicentric Randomized Trial Comparing the Efficacy and Safety of S... |
| NCT06457412 | NA | RECRUITING | 200 | Programme for Intervention in Paediatric Obesity |
| NCT05949879 | NA | RECRUITING | 80 | Dose Response Effects of Pecan Consumption |
| NCT05750602 | NA | COMPLETED | 40 | Effect of the Food Supplement LIMICOL on LDL Cholesterol and Muscle Function in ... |
| NCT06317883 | N/A | ACTIVE_NOT_RECRUITING | 1508 | Longitudinal Study To Determine The Risk Factors Associated With Childhood Obesi... |
| NCT05798494 | NA | RECRUITING | 140 | PRE-Pregnancy Weight Loss And the Reducing Effect on CHILDhood Overweight - Aarh... |
| NCT03693287 | PHASE4 | UNKNOWN | 150 | Personalized Versus Standardized Parenteral Nutrition for Preterm Infants With a... |
| NCT01556906 | PHASE2 | COMPLETED | 6 | A Phase II Open Label, Dose-Escalation Study to Determine the Safety, Tolerabili... |
| NCT03115086 | N/A | ACTIVE_NOT_RECRUITING | 55 | A Prospective, Observational, Non-Interventional, Post-Marketing, Patient Regist... |
| NCT07140445 | N/A | NOT_YET_RECRUITING | 175 | Monitoring Neurocognitive Dysfunction and the Impact of Metabolism and Physical ... |
| NCT05174663 | NA | COMPLETED | 75 | A Randomized, Comparator-controlled Parallel Study to Investigate the Dose Respo... |
| NCT07246408 | NA | RECRUITING | 75 | Intermittent Cottonseed Oil Consumption on Cardiovascular Disease Risk Reduction |
| NCT02009748 | PHASE2 | COMPLETED | 36 | Vitamin D Supplementation in Cirrhotic Patients: A Randomized, Multi-center, Dou... |
| NCT07191704 | N/A | RECRUITING | 150 | Characterization of Progressive Familial Intrahepatic Cholestasis (PFIC)-Related... |
| NCT04475276 | PHASE4 | COMPLETED | 120 | Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized ... |
| NCT06815978 | N/A | RECRUITING | 150 | Validation of ESPEN-EASO Algorithm for the Diagnosis of Sarcopenic Obesity (SO) |
| NCT02011789 | NA | COMPLETED | 10 | A Pilot Study To Determine The Metabolism And Health Effects Of Citrus Limonoids... |
| NCT06465810 | N/A | RECRUITING | 1850 | A Non-interventional, Prospective, Multi-country Study Collecting Real-world Dat... |
| NCT00265148 | PHASE2 | COMPLETED | 80 | Effects of Avandia on Cognition and Cerebral Glucose Utilisation in Subjects Wit... |
| NCT02443155 | PHASE2 | COMPLETED | 308 | A Randomised, Double-blind, Double-dummy, Placebo-controlled, Parallel-group Mul... |
| NCT02062034 | PHASE2 | COMPLETED | 61 | Efficacy of Ubiquinone and Combined Antioxidant Therapy on Progression, Oxidativ... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 481976 | 1979 | Article | Pediatrics | Vitamin E and neonatal bilirubinemia. |
| 803225 | 1975 | Article | The New England journal of med | Neonatal nonhemolytic jaundice. |
| 40886428 | 2025 | Article | Nutrition research (New York, | Dietary vitamin E intake is associated with lower mortality among individuals wi... |
| 3036938 | 1987 | Article | Journal of hepatology | Vitamin E deficiency and its clinical significance in adults with primary biliar... |
| 3245661 | 1988 | Article | Annals of the New York Academy | Membrane antioxidants. |
| 25596209 | 2016 | Article | JPEN. Journal of parenteral an | Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutritio... |
| 29560688 | 2017 | Article | Acta gastro-enterologica Belgi | Prevalence of fat-soluble vitamin (A, D, and E) and zinc deficiency in patients ... |
| 34919247 | 2021 | Article | European review for medical an | A randomized controlled trial comparing the effects of Vitamin E, Ursodeoxycholi... |
| 35204062 | 2022 | Article | Antioxidants (Basel, Switzerla | Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: ... |
| 36459516 | 2022 | Article | PloS one | Vitamin E supplementation improves post-transportation systemic antioxidant capa... |
| 8201221 | 1994 | Article | Journal of hepatology | Low vitamin E content in plasma of patients with alcoholic liver disease, hemoch... |
| 26471989 | 2017 | Article | JPEN. Journal of parenteral an | Supplemental Parenteral Vitamin E Into Conventional Soybean Lipid Emulsion Does ... |
| 23912327 | 2013 | Article | Nutrients | Plasma and dietary antioxidant status as cardiovascular disease risk factors: a ... |
| 28602070 | 2017 | Article | Minerva medica | A prognostic evaluation and management of alcoholic hepatitis. |
| 16978760 | 2006 | Article | Toxicology | Deltamethrin-induced oxidative damage and biochemical alterations in rat and its... |
| 3966426 | 1985 | Article | The American journal of clinic | Vitamin E deficiency in adults with chronic liver disease. |
| 10399480 | 1999 | Article | Zentralblatt fur Veterinarmedi | A study of lipid peroxidation and vitamin E in dairy cows with hepatic insuffici... |
| 20666718 | 2010 | Article | Current medicinal chemistry | A review of natural and synthetic antioxidants important for health and longevit... |
| 33676282 | 2021 | Article | Clinics and research in hepato | Coenzyme Q10 deficiency in patients with hereditary hemochromatosis. |
| 19917523 | 2009 | Article | Biomedicine & pharmacotherapy | Effects of hormone replacement therapy with vitamin C and E supplementation on p... |
3. hereditary North American Indian childhood cirrhosis L5 99.99%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. drug-induced liver injury L1 99.97%
臨床試驗（8 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT02831673 | PHASE3 | COMPLETED | 719 | A Phase III, Randomised, Double Blind, Multicentre, Parallel Group, Non Inferior... |
| NCT02831764 | PHASE3 | COMPLETED | 722 | A Phase III, Randomised, Double-blind, Multicentre, Parallel-group, Non-inferior... |
| NCT03446573 | PHASE3 | COMPLETED | 743 | A Phase III, Randomized, Multicenter, Parallel-group, Non-inferiority Study Eval... |
| NCT02654665 | PHASE3 | UNKNOWN | 36 | Comparing Effects of Liraglutide and Bariatric Surgery on Weight Loss, Liver Fun... |
| NCT07191704 | N/A | RECRUITING | 150 | Characterization of Progressive Familial Intrahepatic Cholestasis (PFIC)-Related... |
| NCT01793168 | N/A | RECRUITING | 20000 | Coordination of Rare Diseases at Sanford |
| NCT02043054 | PHASE3 | COMPLETED | 90 | Impact of Liraglutide on Cardiac Function and Structure in Young Adults With Typ... |
| NCT04125199 | NA | COMPLETED | 15 | Effects of Decohexaenoic Acid Supplementation on Markers of Inflammatory Muscle ... |
相關文獻（19 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 31599191 | 2019 | Article | Ultrastructural pathology | Vitamin E protects against monosodium glutamate-induced acute liver injury and h... |
| 33396130 | 2021 | Article | Ecotoxicology and environmenta | Vitamin E protects against cadmium-induced sub-chronic liver injury associated w... |
| 20020270 | 2010 | Article | Handbook of experimental pharm | Troglitazone. |
| 32767013 | 2020 | Article | Environmental science and poll | The protective efficacy of vitamin E and cod liver oil against cisplatin-induced... |
| 33617844 | 2021 | Article | Biochemical pharmacology | Vitamin E pretreated Wharton's jelly-derived mesenchymal stem cells attenuate CC... |
| 29849926 | 2018 | Article | Oxidative medicine and cellula | Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Li... |
| 28166421 | 2017 | Article | Biotechnic & histochemistry : | Vitamin E and selenium treatment of monocrotaline induced hepatotoxicity in rats... |
| 8723319 | 1996 | Article | Seminars in liver disease | Metal-induced hepatotoxicity. |
| 31618080 | 2020 | Article | Toxicology mechanisms and meth | Vitamin E supplementation ameliorates the hepatotoxicity induced by Tramadol: to... |
| 29068590 | 2017 | Article | Advances in clinical and exper | Vitamin E (α tocopherol) attenuates toxicity and oxidative stress induced by afl... |
| 25896716 | 2015 | Article | Cellular physiology and bioche | Potential antifibrotic and angiostatic impact of idebenone, carnosine and vitami... |
| 31535700 | 2019 | Article | La Tunisie medicale | Protective role of vitamin E against cadmium induced oxidative stress into the r... |
| 32664576 | 2020 | Article | International journal of molec | Ferroptosis in Liver Diseases: An Overview. |
| 900683 | 1977 | Article | Annals of internal medicine | Host susceptibility and acetaminophen liver injury. |
| 12927377 | 2003 | Article | Toxicology | Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in ... |
| 31519295 | 2019 | Article | Complementary therapies in med | Panax ginseng is superior to vitamin E as a hepatoprotector against cyclophospha... |
| 15959406 | 2005 | Article | Annales d'endocrinologie | [Nonalcoholic steatohepatitis]. |
| 21796379 | 2012 | Article | Age (Dordrecht, Netherlands) | Vitamin E prevents the age-dependent and palmitate-induced disturbances of sphin... |
| 30887259 | 2019 | Article | Molecular biology reports | Effects of vitamin A and vitamin E on attenuation of titanium dioxide nanopartic... |
5. microvillus inclusion disease L5 99.96%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
6. hyperbiliverdinemia L5 99.96%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
7. Navajo neurohepatopathy L5 99.96%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
8. nevus of Ito L4 99.96%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 29677015 | 2018 | Article | Dermatologic surgery : officia | Oral Tranexamic Acid for the Treatment of Melasma: A Review. |
| 37737953 | 2023 | Article | Molecular diagnosis & therapy | Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Re... |
| 18681152 | 2008 | Article | Journal of drugs in dermatolog | Topical vitamins. |
| 38071959 | 2024 | Article | Dermatology (Basel, Switzerlan | Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined... |
| 21510012 | 2010 | Article | Pediatric dermatology | Yellow nail syndrome. |
| 22986950 | 2013 | Article | Skin pharmacology and physiolo | The antioxidant role of paraoxonase 1 and vitamin E in three autoimmune diseases... |
| 39624091 | 2024 | Article | Frontiers in immunology | Healthy lifestyle choices: new insights into vitiligo management. |
| 32815582 | 2021 | Article | International journal of derma | Treatment of melasma: a review of less commonly used antioxidants. |
| 29721969 | 2018 | Article | Advances in experimental medic | Bisretinoid Photodegradation Is Likely Not a Good Thing. |
| 25285994 | 2015 | Article | Dermatologic therapy | Evaluation of an oral supplement containing Phyllanthus emblica fruit extracts, ... |
| 28241848 | 2017 | Article | Orphanet journal of rare disea | Yellow nail syndrome: a review. |
| 25607790 | 2014 | Article | Journal of drugs in dermatolog | Evaluation of efficacy and tolerance of a nighttime topical antioxidant containi... |
| 21585272 | 2011 | Article | Clinical toxicology (Philadelp | Secretion of arsenic, cholesterol, vitamin E, and zinc from the site of arsenica... |
| 5098962 | 1971 | Article | Science (New York, N.Y.) | Ceroid pigment formation and irreversible sterility in vitamin E deficiency. |
| 11809591 | 2002 | Article | European journal of dermatolog | The effects of vitamin E on the skin lipid peroxidation and the clinical improve... |
| 39355739 | 2024 | Article | Skin health and disease | Explicating the multifunctional roles of tocotrienol and squalene in promoting s... |
| 7469656 | 1980 | Article | Archivos de investigacion medi | Vitamin E and methylene blue in the prevention of abnormal pigmentation in the s... |
| 27050703 | 2016 | Article | Journal of drugs in dermatolog | An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol... |
| 32593085 | 2020 | Article | Journal of trace elements in m | Serum level of antioxidant vitamins and minerals in patients with vitiligo, a sy... |
| 39861486 | 2025 | Article | Nutrients | Dietary Interventions, Supplements, and Plant-Derived Compounds for Adjunct Viti... |
9. adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency L5 99.95%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
10. mitochondrial DNA depletion syndrome, hepatocerebral form L5 99.93%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
資料來源：DDInter 2.0（原文內容請參閱該網站）
**Malabsorption Syndromes** 🔴 Major
- 注意事項：Vitamin E is readily absorbed from the intestinal tract in the presence of bile...
**肝臟疾病** 🟢 Minor
- 注意事項：Vitamin E is fat soluble and many oral formulations require bile for adequate intestinal absorption...
## 結論與下一步
**決策：Proceed with Caution**
**理由：**
Vitamin E 在膽紅素代謝異常相關疾病中的輔助治療具有生物學合理性，早期文獻支持其在新生兒黃疸中的效果。但證據等級仍需提升。
**若要推進需要：**
- 針對特定膽紅素代謝異常疾病的隨機對照試驗
- 確定最佳劑量和劑型（尤其是膽汁淤積患者的水溶性劑型）
- 長期安全性監測數據
- 與現有標準治療（如光療、換血）的比較評估
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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