Sulfamethazine
證據等級: L5 | 預測適應症: 6 個
## 藥師評估報告
Sulfamethazine（磺胺二甲嘧啶）：從抗菌劑到多元感染症之探索
一句話總結
Sulfamethazine 是傳統磺胺類廣效抗菌劑，TxGNN 預測其可能對糖尿病腎病變及結膜炎有潛力，有文獻支持其與糖尿病微血管病變的藥物代謝關聯，但台灣所有許可證均已註銷。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 磺胺劑、革蘭氏陽性及陰性菌感染症 |
| 預測新適應症 | gout、brain small vessel disease 1 with or without ocular anomalies、autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome、diabetic nephropathy、conjunctivitis、bronchitis |
| TxGNN 預測分數 | 0.998（diabetic nephropathy） |
| 證據等級 | L4（有 PubMed 文獻支持） |
| 台灣上市 | 所有許可證已註銷 |
| 許可證數 | 59 張（全部已註銷） |
| 建議決策 | Hold |
預測適應症詳細分析
1. gout L3 99.87% 主要分析
為什麼這個預測合理？
臨床試驗
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01245127 | PHASE2 | COMPLETED | 1 | Ilaris (Canakinumab) in the Schnitzler Syndrome. A Case Series. |
| NCT06695182 | N/A | ACTIVE_NOT_RECRUITING | 3000 | the Real-world Data of Risk Factor and Its Prognosis in PREmature Coronary ARter... |
2. brain small vessel disease 1 with or without ocular anomalies L4 99.83%
相關文獻（19 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35882526 | 2023 | Article | Journal of medical genetics | Axenfeld-Rieger syndrome: more than meets the eye. |
| 30182440 | 2018 | Article | American journal of medical ge | Neuropathology of holoprosencephaly. |
| 33870948 | 2022 | Article | Journal of neuro-ophthalmology | Optic Nerve Aplasia. |
| 11941259 | 2002 | Article | Journal francais d'ophtalmolog | [Congenital megalocornea]. |
| 6390155 | 1983 | Article | Neurologic clinics | Optic disk abnormalities. |
| 10498002 | 1999 | Article | Optometry and vision science : | Tilted disc syndrome. |
| 22963965 | 2012 | Article | Annales de dermatologie et de | [Branchio-oculo-facial syndrome]. |
| 1458324 | 1992 | Article | The Veterinary clinics of Nort | Congenital ocular anomalies. |
| 11581073 | 2001 | Article | Ophthalmology | Renal coloboma syndrome. |
| 406376 | 1977 | Article | Journal of pediatric ophthalmo | Peters-Rieger's syndrome. |
| 36636984 | 2023 | Article | Ophthalmic genetics | Congenital inner eyelid folds. |
| 2036354 | 1991 | Article | The British journal of ophthal | Ablepharon macrostomia syndrome. |
| 3050099 | 1988 | Article | Journal of medical genetics | The telecanthus-hypospadias syndrome. |
| 36926528 | 2023 | Article | Clinical ophthalmology (Auckla | Ophthalmological Manifestations of Axenfeld-Rieger Syndrome: Current Perspective... |
| 37468646 | 2024 | Article | Pediatric nephrology (Berlin, | Ocular manifestations of congenital anomalies of the kidney and urinary tract (C... |
| 35791156 | 2022 | Article | Indian journal of ophthalmolog | Clinical features and orbital anomalies in Fraser syndrome and a review of manag... |
| 16848213 | 2006 | Article | Acta medica Croatica : casopis | [Distichiasis]. |
| 30452766 | 2018 | Article | Journal of pediatric ophthalmo | Systemic Associations of Childhood Glaucoma: A Review. |
| 29133973 | 2017 | Article | Clinical ophthalmology (Auckla | Duane retraction syndrome: causes, effects and management strategies. |
3. autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome L5 99.83%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. diabetic nephropathy L2 99.77%
臨床試驗（3 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT06843304 | N/A | RECRUITING | 2000 | The Intelligent Prevention And Control System And Strategy For The Whole Disease... |
| NCT06254677 | N/A | NOT_YET_RECRUITING | 1000 | Western Sydney Kidney Injury Biopsy Study |
| NCT03191396 | PHASE3 | COMPLETED | 577 | Efficacy and Safety of Semaglutide 1.0 mg Once-weekly Versus Liraglutide 1.2 mg ... |
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 9112055 | 1997 | Article | European journal of clinical p | N-acetylation and hydroxylation polymorphisms in type II diabetics with microvas... |
5. conjunctivitis L4 99.43%
相關文獻（4 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 1258314 | 1976 | Article | The Veterinary record | Infectious bovine keratoconjunctivitus. |
| 27893834 | 2016 | Article | PloS one | Selective Pressure Promotes Tetracycline Resistance of Chlamydia Suis in Fatteni... |
| 4563744 | 1972 | Article | Revue internationale du tracho | [The evaluation of controlled trachoma chimiotherapy trial]. |
| 4852056 | 1974 | Article | Archives of ophthalmology (Chi | Five-year perspective on trachoma in the San Xavier Papago Indian. |
6. bronchitis L2 99.34%
臨床試驗（5 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT03964766 | NA | UNKNOWN | 42 | Postoperative Pain Following Pulpectomy of Primary Molars With Rotary Instrument... |
| NCT02742597 | NA | COMPLETED | 175 | Patient-Centred Innovations for Persons With Multimorbidity - Ontario |
| NCT03378661 | PHASE2 | UNKNOWN | 210 | Phase 2 Randomized, Multicenter, Safety and Efficacy Trial to Evaluate Different... |
| NCT01251003 | PHASE1, PHASE2 | WITHDRAWN | 0 | Safety of Autologous Human Umbilical Cord Blood Treatment for Traumatic Brain in... |
| NCT02789800 | NA | COMPLETED | 284 | Patient-Centred Innovations for Persons With Multimorbidity - Quebec |
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 46968 | 1975 | Article | Lancet (London, England) | Editorial: Antimicrobial treatment of chronic bronchitis. |
| 2849814 | 1988 | Article | Thorax | Clinical experience in the management of pulmonary opportunist infection and rej... |
| 1884803 | 1991 | Article | Farmakologiia i toksikologiia | [The pharmacokinetics of the marker preparations antipyrine and sulfadimezine in... |
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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