Sodium Citrate
證據等級: L5 | 預測適應症: 9 個
## 藥師評估報告
Sodium Citrate（檸檬酸鈉）：從抗凝血劑到胃部疾病輔助治療之探索
一句話總結
Sodium Citrate 主要作為抗凝血劑及袪痰劑使用，TxGNN 預測其可能對胃部疾病具有輔助治療潛力，並有多篇文獻支持其在胃癌抑制及胃黏膜保護方面的作用。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 抗凝血劑、袪痰劑、促進利尿、制酸 |
| 預測新適應症 | 胃部疾病（stomach disease）、胃十二指腸炎（gastroduodenitis） |
| TxGNN 預測分數 | 0.999（stomach disease） |
| 證據等級 | L3（有多篇 PubMed 文獻及臨床試驗） |
| 台灣上市 | 有效許可證存在 |
| 許可證數 | 多張（含已註銷） |
| 建議決策 | Watch |
預測適應症詳細分析
1. papillary conjunctivitis L5 99.95% 主要分析
為什麼這個預測合理？
臨床試驗
目前無針對此特定適應症的臨床試驗登記。
</div> </details>2. nasal cavity disease L1 99.95%
臨床試驗（7 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT05063552 | PHASE2, PHASE3 | ACTIVE_NOT_RECRUITING | 430 | A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab v... |
| NCT02196168 | PHASE2 | TERMINATED | 6 | A Randomized Phase II Trial of Cisplatin With or Without Wee1 Kinase Inhibitor A... |
| NCT03705793 | PHASE4 | COMPLETED | 53 | Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis |
| NCT05075980 | PHASE2 | RECRUITING | 174 | HEADLIGHT: Hypofractionated Proton Therapy for Head and Neck Cancers |
| NCT00707473 | PHASE2 | ACTIVE_NOT_RECRUITING | 31 | Phase II Trial of Induction Therapy With Docetaxel, Cisplatin and Fluorouracil i... |
| NCT03493425 | PHASE2 | RECRUITING | 82 | Phase II Randomized Trial of Neo-Adjuvant Chemotherapy Followed by Surgery and P... |
| NCT05172245 | PHASE1 | RECRUITING | 46 | Phase 1/1b Study of AKT Inhibitor Ipatasertib With Chemoradiation for Locally Ad... |
3. acute laryngopharyngitis L5 99.94%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. stomach disease L1 99.89%
臨床試驗（50 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT05356000 | NA | RECRUITING | 30 | Determine the Contribution of Paracellular GI Oxalate Absorption in Obese and Ro... |
| NCT03050359 | PHASE3 | COMPLETED | 533 | A Randomized Double-Blind, Double-Dummy, Phase 3 Study to Evaluate the Efficacy ... |
| NCT04493125 | NA | COMPLETED | 104 | The Effect of Mosapride Citrate on Gastrointestinal Motility After Laparoscopic ... |
| NCT01385098 | NA | COMPLETED | 37 | Preoperative Vitamin D Status and Efficacy of Therapeutic Vitamin D Supplementat... |
| NCT04626609 | N/A | COMPLETED | 45 | Prostaglandin and Cannabinoid Receptors in the Development of Eosinophilic Esoph... |
| NCT06473493 | PHASE2, PHASE3 | NOT_YET_RECRUITING | 30 | The Safety and Efficacy of Compound Alverine Citrate Soft Capsules in the Treatm... |
| NCT01266850 | PHASE4 | COMPLETED | 1384 | Safety and Immunogenicity of Sequential Rotavirus Vaccine Schedules With RotaTeq... |
| NCT02830789 | NA | COMPLETED | 38 | Investigation of the Optimal Calcium Supplement Following Roux-en-Y Gastric Bypa... |
| NCT02891447 | PHASE2 | COMPLETED | 24 | A Phase II Study of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal... |
| NCT04721964 | NA | COMPLETED | 24 | Evaluation of the Effects of Routine Iron Supplementation in Children on Gastroi... |
| NCT00285688 | N/A | COMPLETED | 200 | Antibiotic Resistance Helicobacter Pylori and Clarithromycin Resistance Mutation... |
| NCT03040817 | NA | UNKNOWN | 50 | Cooperative Group for Clinical Research in G-POEM (POP), Jiangsu, China |
| NCT06401083 | PHASE4 | RECRUITING | 226 | The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate |
| NCT04491942 | PHASE1 | ACTIVE_NOT_RECRUITING | 74 | A Phase 1 Trial of the ATR Inhibitor BAY 1895344 in Combination With Cisplatin a... |
| NCT02180334 | PHASE4 | COMPLETED | 12 | The Effect of Combination of Mosapride and Dipeptidyl Peptidase-4 (DPP-4) Inhibi... |
| NCT02175901 | PHASE4 | COMPLETED | 215 | Prospective, Randomized Controlled Trial Comparing Amoxicillin and Metronidazole... |
| NCT01948245 | PHASE4 | UNKNOWN | 42 | A Double Blinded, Randomized, Controlled Investigation of Taurolidine-citrate/He... |
| NCT05608577 | N/A | ACTIVE_NOT_RECRUITING | 200 | RE-BLEED: A Digital Platform for Identifying Bleeding Patients - a Feasibility S... |
| NCT03812380 | PHASE3 | TERMINATED | 62 | Averting Complications of Proton Pump Inhibitor Therapy by Effervescent Calcium ... |
| NCT06943794 | NA | NOT_YET_RECRUITING | 4824 | Gastric Cancer Prevention Strategies Based on Eradication of Helicobacter Pylori... |
| NCT06470386 | PHASE2, PHASE3 | NOT_YET_RECRUITING | 178 | The Efficacy and Safety of Compound Alverine Citrate Soft Capsules in the Treatm... |
| NCT06850480 | PHASE3 | RECRUITING | 356 | A Multicenter, Randomized, Double-blind, Double-simulated, Positive Parallel-con... |
| NCT00985608 | PHASE2 | UNKNOWN | 40 | Efficacy of Acetilcysteine in 'Rescue' Therapy for Helicobacter Pylori Infection... |
| NCT05966246 | NA | COMPLETED | 106 | The Effect of Prucalopride Succinate on Gastrointestinal Motility After Laparosc... |
| NCT05836402 | NA | COMPLETED | 14 | Low-Carbohydrate Dietary and Lifestyle Interventions for the Management of Long ... |
| NCT03050307 | PHASE3 | COMPLETED | 234 | A Randomized Double-Blind, Double-Dummy, Phase 3 Study to Evaluate the Efficacy ... |
| NCT06760065 | PHASE3 | NOT_YET_RECRUITING | 316 | A Multicenter, Randomized Controlled Study Comparing Keverprazan Hydrochloride-A... |
| NCT01667718 | PHASE4 | COMPLETED | 161 | Levofloxacin-containing Therapy for Helicobacter Pylori Treatment |
| NCT06510010 | PHASE2 | RECRUITING | 198 | Perioperative Oxaliplatin With S-1 Combined H. Pylori Eradication in the Managem... |
| NCT03452696 | PHASE3 | COMPLETED | 208 | Clinical Trial to Evaluate the Gastric Tolerability and Efficacy of the Food Sup... |
| NCT05998863 | PHASE3 | RECRUITING | 56 | Effervescent Calcium Magnesium Citrate to Prevent Mineral Metabolism and Renal C... |
| NCT04139928 | NA | COMPLETED | 17 | Bioavailability of Single-dose Magnesium Salts |
| NCT03342456 | PHASE4 | COMPLETED | 184 | The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadr... |
| NCT07187492 | PHASE4 | RECRUITING | 180 | Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients... |
| NCT01153204 | PHASE4 | COMPLETED | 30 | Satisfaction With the Treatment, Confidence and Naturalness in Engaging in Sexua... |
| NCT01667575 | PHASE4 | COMPLETED | 180 | Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to T... |
| NCT06696248 | PHASE2, PHASE3 | NOT_YET_RECRUITING | 30 | The Efficacy of Carvedilol Combined with Compound Alverine Citrate Soft Capsules... |
| NCT04905147 | NA | UNKNOWN | 44 | Randomized Controlled Trials of Efficacy of Mosapride on Recovery of Intestinal ... |
| NCT07182890 | PHASE4 | RECRUITING | 180 | Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patie... |
| NCT07139951 | PHASE2 | ENROLLING_BY_INVITATION | 16 | Prophylactic Hyperthermic IntraperitOneal Chemotherapy (p-HIPEC) for pRevention ... |
| NCT05753306 | PHASE2 | RECRUITING | 40 | A Phase II Study of Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemo... |
| NCT02201316 | PHASE1 | COMPLETED | 18 | An Open-label, Randomised, Single Dose, Three-Way Crossover, Six Sequence, Pilot... |
| NCT04213794 | EARLY_PHASE1 | TERMINATED | 2 | A Prospective Study of Heated Intra-Peritoneal Chemotherapy (H.I.P.E.C.) With Do... |
| NCT02555852 | N/A | COMPLETED | 4238504 | Proton Pump Inhibitors and the Risk of Hospitalization for Community-acquired Pn... |
| NCT05196945 | PHASE4 | UNKNOWN | 316 | Vonoprazan Fumarate in Combination With Amoxicillin for the First-line Eradicati... |
| NCT01739231 | PHASE1, PHASE2 | COMPLETED | 81 | Safety, Reactogenicity, Tolerability, Immunogenicity and Efficacy of Live Attenu... |
| NCT05065424 | PHASE4 | SUSPENDED | 58 | Use of Premedication for Less Invasive Surfactant Administration: A Randomized C... |
| NCT02887573 | PHASE4 | UNKNOWN | 62 | Free-residue Nutrients for the Bowel Preparation of Colon Capsule Endoscopy |
| NCT04753437 | PHASE1 | COMPLETED | 44 | A Phase 1, Double-Blind, Parallel Group Study to Evaluate the Safety, Tolerabili... |
| NCT07173504 | NA | RECRUITING | 124 | The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outc... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 27163639 | 2016 | Article | Biochemical and biophysical re | 3-Bromopyruvate and sodium citrate induce apoptosis in human gastric cancer cell... |
| 35934181 | 2022 | Article | Photodiagnosis and photodynami | 5-aminolevulinic acid and sodium ferrous citrate decreased cell viability of gas... |
| 26708213 | 2016 | Article | Oncology reports | 3-bromopyruvate and sodium citrate target glycolysis, suppress survivin, and ind... |
| 24659865 | 2014 | Article | World journal of gastroenterol | What is the best strategy for successful bowel preparation under special conditi... |
| 12684814 | 2003 | Article | Histochemistry and cell biolog | Immunohistochemical localization of sodium-potassium ATPase in human normal stom... |
| 3013486 | 1986 | Article | Clinical nuclear medicine | Nuclear medicine and esophageal surgery. |
| 29913138 | 2018 | Article | The Journal of urology | The Effect of Thiazide and Potassium Citrate Use on the Health Related Quality o... |
| 25073632 | 2014 | Article | Journal of gastroenterology an | Education and Imaging. Gastroenterology: acute mucosal injury of esophagus and s... |
| 32933720 | 2020 | Article | Tissue & cell | Expression of asprosin in rat hepatic, renal, heart, gastric, testicular and bra... |
| 29115645 | 2018 | Article | Oncology reports | Combined 18F-FDG PET/CT imaging and a gastric orthotopic xenograft model in nude... |
| 6489697 | 1984 | Article | Gastroenterology | Effect of sodium taurocholate on the human gastric mucosa at acid and neutral pH... |
| 38114010 | 2024 | Article | International journal of biolo | Gastric acid-responsive deformable sodium alginate/Bletilla striata polysacchari... |
| 25316860 | 2014 | Article | The Journal of infectious dise | Effect of buffer on the immune response to trivalent oral poliovirus vaccine in ... |
| 10499455 | 1999 | Article | Scandinavian journal of gastro | Onset of action of antisecretory drugs: beneficial effects of a rapid increase i... |
| 1777551 | 1991 | Article | Alimentary pharmacology & ther | Protection from gastrointestinal side-effects by azapropazone by its incorporati... |
| 25794247 | 2015 | Article | ASAIO journal (American Societ | Treatment of Severe Metabolic Alkalosis with Continuous Renal Replacement Therap... |
| 14719080 | 2004 | Article | Oncology reports | Vascular endothelial growth factor assessment in different blood fractions of ga... |
| 19530748 | 2009 | Article | Drug safety | The continuing unacceptable marketing of Alka-Seltzer containing aspirin for sto... |
| 31739258 | 2020 | Article | Journal of photochemistry and | Tumor-specific design of PEGylated gadolinium-based nanoscale particles: Facile ... |
| 1149036 | 1975 | Article | Cancer research | Pancreatic adenocarcinoma in inbred guinea pigs induced by n-methyl-N-nitrosoure... |
5. postgastrectomy syndrome L5 99.79%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
6. gastroduodenitis L4 99.62%
7. familial visceral myopathy L5 99.42%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
8. rosacea conjunctivitis L5 99.27%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
9. allergic urticaria L5 99.18%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
資料來源：DDInter 2.0（原文內容請參閱該網站）
**Acid-Base Imbalance** 🟡 Moderate
- 應謹慎使用本藥物。需定期監測。風險包括：心律不整、癲癇發作。
**Water-Electrolyte Imbalance** 🟢 Minor
- 不應使用本藥物。需定期監測。
**Inflammatory Bowel Diseases** 🟢 Minor
- 本藥物在此情況下禁用。
**Intestinal Obstruction** 🟢 Minor
- 本藥物在此情況下禁用。
## 結論與下一步
**決策：Watch**
**理由：**
TxGNN 預測分數極高（0.999），且有多篇高品質體外及動物實驗文獻支持 Sodium Citrate 抑制胃癌細胞的機轉。然而，目前證據仍限於基礎研究階段，尚無針對此適應症的人體臨床試驗。
**若要推進需要：**
- 確立人體安全的抗腫瘤劑量
- 評估口服或靜脈給藥的可行性
- 設計 Phase I 安全性試驗
- 探索與現有胃癌化療藥物的協同作用
- 考慮作為化療增敏劑而非單一療法的定位
---
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---
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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