Nystatin

Name: Nystatin 老藥新用驗證報告
Creator: TwTxGNN Team
Published: 2026-02-19

證據等級: L4 | 預測適應症: 10 個

## 藥師評估報告

Nystatin：從抗真菌藥物到外陰陰道炎

一句話總結

Nystatin 是一種抗真菌藥物，通常用於治療由念珠菌引起的感染。 TxGNN 模型預測它可能對**外陰陰道炎 (Vulvovaginitis)** 有效，目前有 **0 個臨床試驗**和 **20 篇文獻**支持這個方向。

快速總覽

項目	內容
原適應症	對革蘭氏陽性菌及陰性菌所引起之感染症
預測新適應症	vulvovaginal candidiasis、vulvovaginitis、disease of orbital region、disease of orbital part of eye adnexa、cystic teratoma、spinal cord dermoid cyst、postmenopausal atrophic vaginitis、biotin metabolic disease、oral candidiasis、candidiasis
TxGNN 預測分數	99.92%
證據等級	L4
台灣上市	✓ 已上市
許可證數	20 張
建議決策	Proceed with Guardrails

預測適應症詳細分析

1. vulvovaginitis L4 99.92% 主要分析

為什麼這個預測合理？

目前缺乏詳細的作用機轉資料。根據已知資訊，Nystatin 是抗真菌藥物的一部分，

其成分在由念珠菌引起的感染症中的療效已被證實，機轉上可能適用於外陰陰道炎。

</p>

此預測基於藥物的作用機轉，與現有臨床證據方向一致。

臨床試驗

目前無針對此特定適應症的臨床試驗登記。

相關文獻

PMID	年份	類型	期刊	主要發現
25775428	2015	Article	BMJ clinical evidence	Candidiasis (vulvovaginal).
21774671	2011	Article	Journal of women's health (200	Boric acid for recurrent vulvovaginal candidiasis: the clinical evidence.
4919155	1970	Article	The Medical clinics of North A	Nystatin.
12228137	2002	Article	BMJ (Clinical research ed.)	Vulvovaginal candidiasis.
39771534	2024	Article	Pharmaceutics	Fluconazole-Resistant Vulvovaginal Candidosis: An Update on Current Management.
11363911	1996	Article	Journal of the International A	Candidiasis.
21718579	2010	Article	BMJ clinical evidence	Candidiasis (vulvovaginal).
3873872	1985	Article	American journal of obstetrics	Vaginitis.
4601917	1974	Article	The Medical clinics of North A	Vaginitis.
8193418	1994	Article	The Annals of pharmacotherapy	Metronidazole hypersensitivity.
10470518	1999	Article	Comprehensive therapy	Vulvovaginitis in healthy women.
20406393	2011	Article	Mycoses	In vitro fluconazole and nystatin susceptibility and clinical outcome in complic...
32104010	2020	Article	Infection and drug resistance	Antifungal Activity of ZnO Nanoparticles and Nystatin and Downregulation of SAP1...
16047929	2005	Article	Ceska gynekologie	["Mixed" and "miscellaneous" vulvovaginitis: diagnostics and therapy of vaginal ...
16620487	2005	Article	Clinical evidence	Candidiasis (vulvovaginal).
31969236	2019	Article	Acta dermatovenerologica Croat	Effectiveness and Pharmacokinetic evaluation of Geonistin® (Oxytetracyline and N...
37023426	2023	Article	Journal of infection in develo	Comparison of tea tree oil 5%, tea tree oil 10%, and nystatin inhibition zones a...
4584828	1973	Article	The Journal of obstetrics and	A trial of clotrimazole and nystatin in vaginal moniliasis.
19454049	2007	Article	BMJ clinical evidence	Candidiasis (vulvovaginal).
30359236	2018	Article	BMC microbiology	Nystatin enhances the immune response against Candida albicans and protects the ...

</details>

2. disease of orbital region L3 99.90%