Naftifine
證據等級: L1 | 預測適應症: 8 個
## 藥師評估報告
Naftifine：從 皮膚黴菌病 到 皮膚念珠菌病
一句話總結
Naftifine（萘替芬）是一種烯丙胺類局部抗黴菌藥，用於治療皮膚黴菌感染。TxGNN 模型預測它對**皮膚念珠菌病 (cutaneous candidiasis)** 和**花斑癬 (pityriasis versicolor)** 有治療效果，這些預測與其已核准適應症高度一致，有充分文獻支持。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 皮膚黴菌病、表皮念珠菌病、甲黴菌病、花斑癬 |
| 預測新適應症 | dermatophytosis of groin and perianal area、tinea pedis、tinea corporis、cutaneous candidiasis、Majocchi granuloma、ectothrix infectious disease、pityriasis versicolor、endothrix infectious disease |
| TxGNN 預測分數 | 99.84% (皮膚念珠菌病), 99.68% (花斑癬) |
| 證據等級 | L1 |
| 台灣上市 | 已上市 |
| 許可證數 | 多張 |
| 建議決策 | Validate |
預測適應症詳細分析
1. cutaneous candidiasis L4 99.84% 主要分析
為什麼這個預測合理？
Naftifine 通過抑制角鯊烯環氧化酶（squalene epoxidase），阻斷麥角固醇合成，破壞真菌細胞膜完整性。
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此預測基於藥物的作用機轉，與現有臨床證據方向一致。
臨床試驗
目前無針對此特定適應症的臨床試驗登記。
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 18346400 | 2008 | Article | Journal of cutaneous medicine | Naftifine: a review. |
| 1723367 | 1991 | Article | Drugs | Naftifine. A review of its antimicrobial activity and therapeutic use in superfi... |
| 3048914 | 1988 | Article | Cutis | Naftifine cream in the treatment of cutaneous candidiasis. |
| 24196340 | 2013 | Article | Journal of drugs in dermatolog | Optimizing topical antifungal therapy for superficial cutaneous fungal infection... |
| 18840006 | 2008 | Article | Drugs | Topical fenticonazole in dermatology and gynaecology: current role in therapy. |
| 10439936 | 1999 | Article | Drugs | Terbinafine. An update of its use in superficial mycoses. |
| 6388169 | 1984 | Article | Zeitschrift fur Hautkrankheite | [Multicenter double-blind contralateral comparison of naftifin and clotrimazole ... |
| 2620916 | 1989 | Article | Giornale italiano di dermatolo | [Evaluation of the efficacy of a new antimycotic molecule for topical use: nafti... |
| 20677526 | 2010 | Article | Journal of drugs in dermatolog | Naftifine, a topical allylamine. |
2. Majocchi granuloma L4 99.69%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 23278484 | 2013 | Article | Pediatric dermatology | Impetigo-like tinea faciei around the nostrils caused by Arthroderma vanbreusegh... |
3. ectothrix infectious disease L5 99.69%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. pityriasis versicolor L4 99.68%
相關文獻（8 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 10439936 | 1999 | Article | Drugs | Terbinafine. An update of its use in superficial mycoses. |
| 18840006 | 2008 | Article | Drugs | Topical fenticonazole in dermatology and gynaecology: current role in therapy. |
| 22165042 | 2011 | Article | Skinmed | An open-label study of naftifine hydrochloride 1% gel in the treatment of tinea ... |
| 3531847 | 1986 | Article | Mykosen | Naftifine solution (1%) in the treatment of pityriasis versicolor in Zambia. |
| 24196340 | 2013 | Article | Journal of drugs in dermatolog | Optimizing topical antifungal therapy for superficial cutaneous fungal infection... |
| 11952303 | 2002 | Article | Journal of the European Academ | Pityriasis versicolor resembling pityriasis rotunda. |
| 2620916 | 1989 | Article | Giornale italiano di dermatolo | [Evaluation of the efficacy of a new antimycotic molecule for topical use: nafti... |
| 8370053 | 1993 | Article | Casopis lekaru ceskych | [Naftifin--laboratory and clinical experience with a new antimycotic from the al... |
5. endothrix infectious disease L3 99.65%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT02658292 | PHASE2 | WITHDRAWN | 0 | A Double-Blind, Randomized, Vehicle-Control, Multicenter Study to Evaluate the E... |
6. dermatophytosis of scalp or beard L4 99.65%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 34934294 | 2021 | Article | International journal of trich | Beard Reconstruction. |
| 34984089 | 2021 | Article | Indian journal of plastic surg | Beard and Moustache Reconstruction. |
| 37510908 | 2023 | Article | Journal of clinical medicine | Beard Alopecia: An Updated and Comprehensive Review of Etiologies, Presentation ... |
| 38106958 | 2023 | Article | International journal of psych | Stress, a Brief Update. |
| 38936998 | 2024 | Article | Facial plastic surgery clinics | Facial Hair in Hair Restoration Surgery: Beard Transplantation and Beard-To-Scal... |
| 17232589 | 1903 | Article | Journal of anatomy and physiol | The Germ-Cells. |
| 39492201 | 2022 | Article | Facial plastic surgery clinics | Hair Restoration in the Ethnic Patient. |
| 32716531 | 2020 | Article | AORN journal | Clinical Issues-August 2020. |
| 32541711 | 2020 | Article | British dental journal | Beards and masks. |
| 32473165 | 2020 | Article | Developmental biology | Long-lived zebrafish Rohon-Beard cells. |
| 36487685 | 1874 | Article | Hall's journal of health | Beards. |
| 37251589 | 2023 | Article | Evolution letters | The role of recognition error in the stability of green-beard genes. |
| 40642854 | 2025 | Article | Aerospace medicine and human p | Beard Length and the Efficacy of an Aviator Oxygen Mask. |
| 34912672 | 2021 | Article | World journal of plastic surge | Head and Neck Restoration in Scar Alopecia: Hair Transplantation in Scalp, Eyebr... |
| 34984086 | 2021 | Article | Indian journal of plastic surg | Using Nonscalp Hair in Scalp Hair Restoration-Theory and Execution. |
| 36089697 | 2023 | Article | The Journal of craniofacial su | Hair-Bearing Expanded Scalp Flap for Total Beard Reconstruction in Patients With... |
| 26942473 | 2016 | Article | Orthopedics | To Beard or Not to Beard? Bacterial Shedding Among Surgeons. |
| 34146585 | 2021 | Article | Mathematical biosciences | Quantitative analysis of mitochondrial ATP synthesis. |
| 38530738 | 2024 | Article | IEEE transactions on pattern a | Multi-Label Conditional Generation From Pre-Trained Models. |
| 19116220 | 2008 | Article | Integrative cancer therapies | The life and times of John Beard, DSc (1858-1924). |
7. superficial mycosis L4 99.63%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 37355825 | 2023 | Article | The Journal of the Association | Naftifine: A Topical Allylamine for Superficial Dermatophytosis. |
| 18346400 | 2008 | Article | Journal of cutaneous medicine | Naftifine: a review. |
| 1723367 | 1991 | Article | Drugs | Naftifine. A review of its antimicrobial activity and therapeutic use in superfi... |
| 25502847 | 2015 | Article | Mycopathologia | Generalized superficial mycosis caused by Trichophyton raubitschekii in China: c... |
| 33517791 | 2021 | Article | Drug delivery | Development, optimization and characterization of nanoemulsion loaded with clove... |
| 24719057 | 2014 | Article | Journal of drugs in dermatolog | What is new in fungal pharmacotherapeutics? |
| 24196340 | 2013 | Article | Journal of drugs in dermatolog | Optimizing topical antifungal therapy for superficial cutaneous fungal infection... |
| 26895366 | 2016 | Article | Journal of the American Podiat | Azole Resistance in Dermatophytes: Prevalence and Mechanism of Action. |
| 25090020 | 2014 | Article | The Cochrane database of syste | Topical antifungal treatments for tinea cruris and tinea corporis. |
| 10439936 | 1999 | Article | Drugs | Terbinafine. An update of its use in superficial mycoses. |
| 26461833 | 2015 | Article | Journal of drugs in dermatolog | New Topical Therapeutic Options in the Management of Superficial Fungal Infectio... |
| 8996257 | 1997 | Article | Journal of the American Academ | Childhood white superficial onychomycosis caused by Trichophyton rubrum: report ... |
| 18840006 | 2008 | Article | Drugs | Topical fenticonazole in dermatology and gynaecology: current role in therapy. |
| 35244863 | 2022 | Article | Mycopathologia | A Special Tinea Nigra Caused by Curvularia lunata: Case Report and Literature Re... |
| 26151784 | 2015 | Article | Journal of drugs in dermatolog | An Open-Label, Multi-Center, Multiple-Application Pharmacokinetic Study of Nafti... |
| 8118161 | 1993 | Article | Archives of medical research | New topical antifungal drugs. |
| 7619094 | 1994 | Article | Journal of the American Academ | Antifungal agents: an overview. Part II. |
| 1550968 | 1992 | Article | Dermatology (Basel, Switzerlan | Preclinical data and mode of action of amorolfine. |
| 22165042 | 2011 | Article | Skinmed | An open-label study of naftifine hydrochloride 1% gel in the treatment of tinea ... |
| 32232786 | 2020 | Article | Infection | Unusual dermatomycoses caused by Nannizzia nana: the geophilic origin of human i... |
8. tinea profunda L4 99.57%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 23278484 | 2013 | Article | Pediatric dermatology | Impetigo-like tinea faciei around the nostrils caused by Arthroderma vanbreusegh... |
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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