Methionine
證據等級: L5 | 預測適應症: 10 個
## 藥師評估報告
Methionine：從肝機能障礙到痤瘡
一句話總結
Methionine 原本用於治療肝機能障礙及藥物中毒。 TxGNN 模型預測它可能對**痤瘡 (Acne)** 有效， 目前有 **4 篇文獻**支持這個方向，但缺乏臨床試驗證據。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 肝機能障礙 |
| 預測新適應症 | acne (disease)、severe nonproliferative diabetic retinopathy、immature cataract、craniostenosis cataract、mature cataract、diabetes mellitus type 2 associated cataract、tetanic cataract、cortical cataract、nuclear senile cataract、diabetic cataract |
| TxGNN 預測分數 | 99.9996% |
| 證據等級 | L5 |
| 台灣上市 | ✓ 已上市 |
| 許可證數 | 20 張 |
| 建議決策 | Hold |
預測適應症詳細分析
1. acne (disease) L4 100.00% 主要分析
為什麼這個預測合理？
目前缺乏詳細的作用機轉資料。根據已知資訊，Methionine 是一種氨基酸，
在肝機能障礙中的療效已被證實，機轉上可能通過影響同型半胱氨酸代謝間接影響皮膚健康，
但缺乏直接證據支持其對痤瘡的療效。
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此預測基於藥物的作用機轉，與現有臨床證據方向一致。
臨床試驗
目前無針對此特定適應症的臨床試驗登記。
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 11277950 | 2001 | Article | International journal of derma | Elevated plasma homocysteine levels in patients on isotretinoin therapy for cyst... |
| 39357918 | 2024 | Article | BMJ case reports | Novel methylenetetrahydrofolate reductase (MTHFR) mutation presenting with neona... |
| 3161955 | 1985 | Article | The Journal of investigative d | Transient absence of C5a-specific neutrophil function in inflammatory disorders ... |
| 3859500 | 1985 | Article | Journal of the American Academ | Increased plasma chemoattractant in Sweet's syndrome. |
2. severe nonproliferative diabetic retinopathy L5 100.00%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
3. immature cataract L5 100.00%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. craniostenosis cataract L5 100.00%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
5. mature cataract L4 100.00%
相關文獻（5 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 8944543 | 1996 | Article | Experimental eye research | Modifications in lens protein biosynthesis signal the initiation of cataracts in... |
| 16123428 | 2005 | Article | Investigative ophthalmology & | Increased sensitivity of amino-arm truncated betaA3-crystallin to UV-light-induc... |
| 1623946 | 1992 | Article | Experimental eye research | Progressive modifications of mouse lens crystallins in cataracts induced by buth... |
| 2032811 | 1991 | Article | Investigative ophthalmology & | Rapid deterioration of lens fibers in GSH-depleted mouse pups. |
| 12373556 | 2002 | Article | Amino acids | Effects of dietary deficiency of selective amino acids on the function of the co... |
6. diabetes mellitus type 2 associated cataract L5 100.00%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
7. tetanic cataract L5 100.00%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
8. cortical cataract L4 100.00%
相關文獻（13 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 40470040 | 2025 | Article | Frontiers in medicine | Metabolomics analysis of aqueous humor from patients with high-myopia complicate... |
| 27803872 | 2016 | Article | International journal of ophth | Age-related changes in the kinetics of human lenses: prevention of the cataract. |
| 861252 | 1977 | Article | Biochimica et biophysica acta | Oxidative changes in human lens proteins during senile nuclear cataract formatio... |
| 14562163 | 2003 | Article | Current eye research | Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor... |
| 2019339 | 1991 | Article | Fundamental and applied toxico | Developmental toxicity of L-selenomethionine in Macaca fascicularis. |
| 7428852 | 1980 | Article | Experimental eye research | Sulfur oxidation in selected human cortical cataracts and nuclear cataracts. |
| 4085577 | 1985 | Article | Experimental eye research | A temporal and spatial study of the synthesis and degradation of water-soluble a... |
| 8883090 | 1996 | Article | Ophthalmic research | UV-b-induced cataract model in brown-Norway rat eyes combined with preadministra... |
| 23226398 | 2012 | Article | PloS one | The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic... |
| 9840739 | 1998 | Article | Free radical biology & medicin | Induction of apoptosis in the CNS during development by the combination of hyper... |
| 14751276 | 2004 | Article | Neuroscience | An animal model with relevance to schizophrenia: sex-dependent cognitive deficit... |
| 9068374 | 1996 | Article | Experimental eye research | Comparison of lens biochemistry and structure between BSO-treated and glucocorti... |
| 11319274 | 2000 | Article | In vitro & molecular toxicolog | Opacification of isolated rat lenses intoxicated with diethylmaleate: relation t... |
9. nuclear senile cataract L4 100.00%
相關文獻（5 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 861252 | 1977 | Article | Biochimica et biophysica acta | Oxidative changes in human lens proteins during senile nuclear cataract formatio... |
| 2515071 | 1989 | Article | Experimental eye research | The reaction of proteins with 3-hydroxyanthranilic acid as a possible model for ... |
| 31832924 | 2020 | Article | Biological trace element resea | Effects of Sodium Selenite on Oxidative Damage in the Liver, Kidney and Brain in... |
| 6705843 | 1984 | Article | Experimental eye research | The effects of hydrogen peroxide on lens proteins: a possible model for nuclear ... |
| 19649175 | 2009 | Article | Molecular vision | Mutation analysis of congenital cataract in a Basotho family identified a new mi... |
10. diabetic cataract L4 100.00%
相關文獻（10 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 39656472 | 2024 | Article | Investigative ophthalmology & | Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Chan... |
| 26343924 | 2015 | Article | Clinica chimica acta; internat | Homocysteine in ocular diseases. |
| 8680624 | 1996 | Article | Annals of epidemiology | Food and nutrient intake and risk of cataract. |
| 9872926 | 1999 | Article | FASEB journal : official publi | Contributions of polyol pathway to oxidative stress in diabetic cataract. |
| 40172029 | 2025 | Article | The International journal of d | Unraveling hepatic consequences of intrauterine growth restriction and catch-up ... |
| 7832436 | 1994 | Article | Annals of the New York Academy | Antioxidant properties of lipoic acid and its therapeutic effects in prevention ... |
| 23270945 | 2013 | Article | Life sciences | Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced ap... |
| 12714643 | 2003 | Article | Investigative ophthalmology & | Vitamin C metabolomic mapping in the lens with 6-deoxy-6-fluoro-ascorbic acid an... |
| 22713178 | 2012 | Article | Experimental eye research | Involvement of MsrB1 in the regulation of redox balance and inhibition of peroxy... |
| 7070760 | 1982 | Article | Ophthalmic research | Partial purification and characterization of lenticular S-adenosylmethionine syn... |
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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