Lidocaine
證據等級: L5 | 預測適應症: 10 個
## 藥師評估報告
Lidocaine：從局部麻醉到點狀上皮角結膜炎
一句話總結
Lidocaine 原本用於局部麻醉。 TxGNN 模型預測它可能對**點狀上皮角結膜炎 (punctate epithelial keratoconjunctivitis)** 有效， 但目前沒有臨床試驗或文獻支持這個方向。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 牙科之表面麻醉、浸潤麻醉、傳達麻醉、局部麻醉 |
| 預測新適應症 | punctate epithelial keratoconjunctivitis、papillary conjunctivitis、rosacea conjunctivitis、exposure keratitis、atopic conjunctivitis、conjunctival disorder、nephrotic syndrome、non-human animal disease、tinea corporis、sporadic idiopathic steroid-resistant nephrotic syndrome |
| TxGNN 預測分數 | 99.99% |
| 證據等級 | L5 |
| 台灣上市 | ✓ 已上市 |
| 許可證數 | 20 張 |
| 建議決策 | Hold |
預測適應症詳細分析
1. punctate epithelial keratoconjunctivitis L5 99.99% 主要分析
為什麼這個預測合理？
目前缺乏詳細的作用機轉資料。根據已知資訊，Lidocaine 是局部麻醉劑的一部分，
其成分在局部麻醉中的療效已被證實，機轉上可能適用於減少角膜上皮的刺激和炎症，
但缺乏直接證據支持其對點狀上皮角結膜炎的療效。
</details>2. papillary conjunctivitis L5 99.98%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
3. rosacea conjunctivitis L5 99.92%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. exposure keratitis L4 99.87%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 8862924 | 1996 | Article | Cornea | Keratitis in methamphetamine abusers. |
5. atopic conjunctivitis L3 99.86%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT04365205 | N/A | RECRUITING | 60 | Effect of Benralizumab on Airway Remodeling in Asthma |
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 37819721 | 2023 | Article | JCI insight | A nerve-goblet cell association promotes allergic conjunctivitis through rapid a... |
| 8039024 | 1994 | Article | Clinical and experimental alle | Effect of nasal anaesthesia on lacrimal function after nasal allergen challenge. |
| 5422136 | 1970 | Article | Die Pharmazie | [Prothanon eyedrops. 1. Results of experimental animal and orientative clinical ... |
6. conjunctival disorder L1 99.84%
臨床試驗（17 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT02324166 | PHASE4 | UNKNOWN | 54 | Cefazolin-Lidocaine Solution for Reducing Pain Associated With Subconjunctival A... |
| NCT05362253 | NA | COMPLETED | 40 | The Effect of Micro-Conjunctival Autografting Combined With Amniotic Membrane Tr... |
| NCT05925894 | NA | COMPLETED | 60 | Efficacy of the Intracamerally Administered Mydriatics for Cataract Surgery in P... |
| NCT01898728 | NA | COMPLETED | 101 | Comparison of the Effectiveness of Povidone-iodine in Reducing Conjunctival Bact... |
| NCT04680078 | NA | UNKNOWN | 24 | A Comparison Between Placement of Three Interrupted Sutures After Triangular Thr... |
| NCT02684786 | PHASE1 | WITHDRAWN | 0 | A Phase I Study of Stellate Ganglion Block and / or Reserpine in Group 2 Pulmona... |
| NCT01087489 | NA | COMPLETED | 53 | Clinical Comparison of Two Anesthetic Preparations for Intravitreal Injection |
| NCT03397069 | NA | COMPLETED | 90 | Efficacy of Midazolam Addition to Local Anesthetic in Peribulbar Block. Randomiz... |
| NCT06353776 | NA | COMPLETED | 15 | MicroPulse Transscleral Laser Therapy and Its Short-term Impact on Ocular Surfac... |
| NCT04018482 | PHASE4 | COMPLETED | 50 | Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study) |
| NCT05314673 | PHASE4 | COMPLETED | 60 | Preoperative Intra-lesional Bevacizumab Injection in Primary Pterygium in Tunisi... |
| NCT01350024 | NA | COMPLETED | 34 | Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in... |
| NCT03189329 | PHASE4 | COMPLETED | 66 | The Effect of Retrobulbar Block on Bi-Hemispheric Cerebral Oxygen Saturation and... |
| NCT05978687 | PHASE4 | UNKNOWN | 50 | The Use of Lidocaine Ophtesic Gel Versus Subconjunctival Xylocaine Injection in ... |
| NCT02150460 | PHASE4 | COMPLETED | 100 | A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surger... |
| NCT03480711 | NA | COMPLETED | 40 | Modified Trabeculectomy With an Extended Subscleral Tunnel Versus Conventional T... |
| NCT03902925 | PHASE1, PHASE2 | COMPLETED | 56 | Pain During Pars Plana Vitrectomy Comparing Peribulbar Anesthesia Versus Sub-ten... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 34003160 | 2021 | Article | Neurology India | SUNCT and SUNA: An Update. |
| 29720816 | 2018 | Article | Annals of Indian Academy of Ne | Short-Lasting Unilateral Neuralgiform Headache Attacks. |
| 19250287 | 2009 | Article | Cephalalgia : an international | Neuropsychiatric side-effects of lidocaine: examples from the treatment of heada... |
| 12828881 | 2003 | Article | Current pain and headache repo | Short-lasting unilateral neuralgiform headache with conjunctival injection and t... |
| 38415675 | 2024 | Article | Cephalalgia : an international | SUNCT, SUNA and short-lasting unilateral neuralgiform headache attacks: Debates ... |
| 17598764 | 2007 | Article | Cephalalgia : an international | Short-lasting unilateral neuralgiform headache attacks with conjunctival injecti... |
| 23330822 | 2013 | Article | Current eye research | Ocular pain after intravitreal injection. |
| 33361408 | 2021 | Article | Journal of neurology, neurosur | Medical treatment of SUNCT and SUNA: a prospective open-label study including si... |
| 18253766 | 2008 | Article | Schmerz (Berlin, Germany) | [Pathophysiology and treatment of trigeminal autonomic cephalalgias]. |
| 33191307 | 2020 | Article | Brain and nerve = Shinkei kenk | [Clinical Aspects of Short-Lasting Unilateral Neuralgiform Headache Attacks]. |
| 37819721 | 2023 | Article | JCI insight | A nerve-goblet cell association promotes allergic conjunctivitis through rapid a... |
| 21876597 | 2011 | Article | Nepalese journal of ophthalmol | Ophthalmomyiasis in humans. |
| 10696746 | 2000 | Article | Retina (Philadelphia, Pa.) | Topical anesthesia in posterior vitrectomy. |
| 20622701 | 2010 | Article | Ophthalmic plastic and reconst | A technique for capturing migratory periocular worms: a case series and review o... |
| 31923328 | 2020 | Article | International journal of paedi | Treatment for oral lesions in pediatric patients with Stevens-Johnson's syndrome... |
| 16954710 | 2006 | Article | Ophthalmologica. Journal inter | Pain relief after pterygium surgery with viscous lidocaine. |
| 21492386 | 2011 | Article | Veterinary anaesthesia and ana | Arrhythmias and transient changes in cardiac function after topical administrati... |
| 30929813 | 2019 | Article | Ophthalmology. Retina | Predictors of Endophthalmitis after Intravitreal Injection: A Multivariable Anal... |
| 15799734 | 2005 | Article | Acta ophthalmologica Scandinav | Efficacy of lidocaine 2% gel in pterygium surgery. |
| 29279652 | 2017 | Article | Middle East African journal of | Evaluation of Topical Lignocaine Jelly 2% for Recurrent Pterygium Surgery with G... |
7. nephrotic syndrome L4 99.83%
8. non-human animal disease L3 99.82%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT02076945 | NA | COMPLETED | 75 | Characteristics of Popliteal Sciatic Nerve Block in Patients With and Without Di... |
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 19858165 | 2010 | Article | Laboratory animals | Accidental induced seizures in three cynomologus macaques following administrati... |
9. tinea corporis L4 99.82%
10. sporadic idiopathic steroid-resistant nephrotic syndrome L5 99.79%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
資料來源：DDInter 2.0（原文內容請參閱該網站）
**Water-Electrolyte Imbalance** 🟡 Moderate
- 需定期監測。
**Cardiomyopathies** 🟢 Minor
- 風險包括：低血壓、心律不整。可能有嚴重不良反應。
**Arrhythmias, Cardiac** 🟢 Minor
- 應謹慎使用本藥物。風險包括：心律不整。可能危及生命。
**肝臟疾病** 🟢 Minor
- 需定期監測。
**腎臟疾病** 🟢 Minor
- 需定期監測。
**Seizures** 🟢 Minor
- 需定期監測。風險包括：癲癇發作。
**Sick Sinus Syndrome** 🟢 Minor
- 本藥物在此情況下禁用。風險包括：心律不整。
## 結論與下一步
**決策：Hold**
**理由：**
目前缺乏支持 Lidocaine 用於點狀上皮角結膜炎的臨床試驗和文獻證據。
**若要推進需要：**
- 進一步的臨床試驗以評估 Lidocaine 在眼科適應症中的有效性和安全性
- 詳細的藥物作用機轉資料（MOA）
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## 相關藥物報告
- [Oxytetracycline](/drugs/oxytetracycline/) - 證據等級 L5
- [Methocarbamol](/drugs/methocarbamol/) - 證據等級 L5
- [Sodium Citrate](/drugs/sodium_citrate/) - 證據等級 L5
- [Salicylic Acid](/drugs/salicylic_acid/) - 證據等級 L5
- [Polyethylene Glycol](/drugs/polyethylene_glycol/) - 證據等級 L5
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本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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