Gemcitabine
證據等級: L2 | 預測適應症: 10 個
## 藥師評估報告
Gemcitabine：從轉移性大腸直腸癌到女性乳腺癌
一句話總結
Gemcitabine 原本用於治療多種癌症，包括轉移性大腸直腸癌。 TxGNN 模型預測它可能對**女性乳腺癌 (female breast carcinoma)** 有效， 目前有 **10 個臨床試驗**和 **12 篇文獻**支持這個方向。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 轉移性大腸直腸癌 |
| 預測新適應症 | 女性乳腺癌、hereditary breast ovarian cancer syndrome、ovarian clear cell adenocarcinoma、primary non-gestational choriocarcinoma of ovary、maligant granulosa cell tumor of ovary、ovarian mucinous adenocarcinoma、ovarian endometrioid adenocarcinoma、yolk sac tumor、ovarian small cell carcinoma、rectum mucinous adenocarcinoma |
| TxGNN 預測分數 | 99.98% |
| 證據等級 | L2 |
| 台灣上市 | ✓ 已上市 |
| 許可證數 | 20 張 |
| 建議決策 | Proceed with Guardrails |
預測適應症詳細分析
1. female breast carcinoma L1 99.98% 主要分析
為什麼這個預測合理？
目前缺乏詳細的作用機轉資料。根據已知資訊，Gemcitabine 是抗癌藥物的一部分，
其成分在轉移性大腸直腸癌中的療效已被證實，機轉上可能適用於女性乳腺癌。
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此預測基於藥物的作用機轉，與現有臨床證據方向一致。
臨床試驗
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT03329950 | PHASE1 | COMPLETED | 132 | A Phase 1 Study of CDX-1140 as Monotherapy or in Combination in Patients With Ad... |
| NCT02632448 | PHASE1, PHASE2 | COMPLETED | 229 | A Phase 1b/2a Three-Part Open-Label Multicenter Study to Evaluate the Safety and... |
| NCT06027268 | PHASE2 | ACTIVE_NOT_RECRUITING | 36 | ToPCourT: A Phase II Trial of Trilaciclib, Pembrolizumab, Gemcitabine and Carbop... |
| NCT05809895 | PHASE2 | WITHDRAWN | 0 | AdvanTIG-211: A Randomized, Double-blind, Placebo-controlled, Phase II Study Eva... |
| NCT00561119 | PHASE3 | COMPLETED | 326 | Phase III, Multicenter, Randomized Trial of Maintenance Versus Observation After... |
| NCT02139358 | PHASE1, PHASE2 | COMPLETED | 15 | Phase I/IIa Trial of Gemcitabine Plus Trastuzumab and Pertuzumab in Previously T... |
| NCT00006459 | PHASE3 | COMPLETED | N/A | Phase III Study of Gemcitabine Plus Paclitaxel Versus Paclitaxel in Patients Wit... |
| NCT00014456 | PHASE1 | COMPLETED | 35 | A Dose-Escalation Trial Of The Combination Of Docetaxel, Gemcitabine And Filgras... |
| NCT06098378 | N/A | UNKNOWN | 30 | Retrospective Study of Patients With Thrombotic Microangiopathy Associated With ... |
| NCT01881230 | PHASE2, PHASE3 | COMPLETED | 191 | A Phase 2/3, Multi-Center, Open-Label, Randomized Study of Weekly Nab®-Paclitaxe... |
| NCT00100750 | PHASE1, PHASE2 | COMPLETED | 31 | Gemcitabine and R115777 Combination Therapy for Metastatic Breast Cancer |
| NCT03997968 | PHASE1, PHASE2 | COMPLETED | 169 | A Multi-Center, Open Label Phase 1/2 Study of CYT-0851 in Patients With Relapsed... |
| NCT04491942 | PHASE1 | ACTIVE_NOT_RECRUITING | 74 | A Phase 1 Trial of the ATR Inhibitor BAY 1895344 in Combination With Cisplatin a... |
| NCT02046421 | PHASE1 | COMPLETED | 31 | Carboplatin, Gemcitabine, and Mifepristone for Advanced Breast Cancer and Recurr... |
| NCT01050322 | PHASE2 | COMPLETED | 142 | A Randomized Open-Label, Phase II Study of Lapatinib-capecitabine or Lapatinib-v... |
| NCT04060342 | PHASE1 | TERMINATED | 61 | A Phase 1/2, First-in-Human, Open-label, Dose Escalation Study of GB1275 Monothe... |
| NCT00005614 | PHASE2 | WITHDRAWN | 0 | Management of Metastatic Breast Cancer in Frail Patients |
| NCT00795678 | N/A | COMPLETED | 10 | Clinical Study to Assess Entry of Chemotherapeutic Agents Into Brain Metastases ... |
| NCT00003540 | PHASE2 | COMPLETED | 30 | Phase II Study of Gemcitabine in the Treatment of Patients With Metastatic Breas... |
| NCT00565851 | PHASE3 | ACTIVE_NOT_RECRUITING | 1052 | A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (... |
| NCT01905592 | PHASE3 | TERMINATED | 216 | A Phase III, Randomized, Open Label, Multicenter, Controlled Trial of Niraparib ... |
| NCT00070278 | PHASE3 | UNKNOWN | 800 | A Phase III Randomized Neoadjuvant Study of Sequential Epirubicin/Cyclophosphami... |
| NCT01595061 | PHASE2 | UNKNOWN | 57 | A Phase II Trial Evaluating Cisplatin (NSC #119875) and Gemcitabine (NSC #613327... |
| NCT03678883 | PHASE2 | ACTIVE_NOT_RECRUITING | 350 | Phase 1/2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3β) Inhibito... |
| NCT04579224 | PHASE3 | RECRUITING | 184 | A Phase III Randomized Trial of Eribulin (NSC #707389) With Gemcitabine Versus S... |
| NCT00006007 | PHASE2 | COMPLETED | 59 | A Phase II Study of a Combination of MTA (LY231514) and Gemcitabine in Patients ... |
| NCT00942331 | PHASE3 | COMPLETED | 506 | A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, an... |
| NCT00039546 | PHASE3 | UNKNOWN | N/A | 'tAnGo', A Phase III Randomised Trial Of Gemcitabine In Paclitaxel-Containing, E... |
| NCT02996825 | PHASE1 | COMPLETED | 44 | A Phase I Dose-Escalation Safety and Tolerability Study of MirvetuximabSoravtans... |
| NCT00004095 | PHASE1 | COMPLETED | 38 | Phase I Trial of Irinotecan (CPT-11) and Gemcitabine in Patients With Solid Tumo... |
| NCT00462865 | PHASE2 | TERMINATED | 18 | A Phase II Study of Adjuvant Gemcitabine/Capecitabine and Bevacizumab for Patien... |
| NCT04279509 | NA | UNKNOWN | 35 | Selecting Chemotherapy With High-throughput Drug Screen Assay Using Patient Deri... |
| NCT00093795 | PHASE3 | COMPLETED | 4894 | A Phase III, Adjuvant Trial Comparing Three Chemotherapy Regimens in Women With ... |
| NCT05770713 | N/A | COMPLETED | 48 | Treatment Patterns And Clinical Outcomes Among Patients Receiving CDK4/6 Inhibit... |
| NCT00244933 | PHASE2 | COMPLETED | 19 | Phase II Trial of Gemcitabine and Genistein in Metastatic Breast Cancer Patients... |
| NCT07097142 | PHASE3 | RECRUITING | 486 | The Phase III Adaptive Radiation and Chemotherapy for Muscle Invasive Bladder Ca... |
| NCT06630325 | PHASE2 | ACTIVE_NOT_RECRUITING | 30 | Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART)... |
| NCT02393248 | PHASE1, PHASE2 | TERMINATED | 201 | A Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of INCB0... |
| NCT03076372 | PHASE1 | UNKNOWN | 34 | A Phase-1 Study Evaluating the Safety, Pharmacology and Preliminary Activity of ... |
| NCT05538663 | PHASE3 | ACTIVE_NOT_RECRUITING | 870 | A Randomized Phase III Trial of Intravesical BCG veRsus Intravesical Docetaxel a... |
| NCT01352494 | PHASE2 | UNKNOWN | 99 | A Multi-center Phase II Trial to Evaluate the Efficacy and Safety of Neoadjuvant... |
| NCT01325558 | PHASE1 | COMPLETED | 30 | A Phase I, Open-Label, Multi-center, Competitive Enrollment and Dose-escalation ... |
| NCT05861830 | PHASE3 | RECRUITING | 80 | An Exploratory Study on Predicting the Efficacy of Dalpiciclib in Combination Wi... |
| NCT00995488 | PHASE2 | TERMINATED | 16 | ABX209: Phase II Trial of Combination ABI-007, Carboplatin, and Gemcitabine for ... |
| NCT00408408 | PHASE3 | UNKNOWN | 1206 | A Randomized Phase III Trial of Neoadjuvant Therapy in Patients With Palpable an... |
| NCT00585689 | PHASE2 | COMPLETED | 29 | A Phase Two Trial of Neoadjuvant ABI-007, Carboplatin and Gemcitabine in Patient... |
| NCT00183794 | PHASE2 | COMPLETED | 20 | Phase II Clinical Trial of Docetaxel in Combination With Gemcitabine in Platinum... |
| NCT00193063 | PHASE2 | COMPLETED | 41 | Phase II Trial of Weekly Gemcitabine and Herceptin in the Treatment of Patients ... |
| NCT03839823 | PHASE2 | COMPLETED | 222 | A Phase II Randomized Study of the Combination of Ribociclib Plus Goserelin Acet... |
| NCT00440622 | PHASE3 | TERMINATED | 90 | A Multicenter Randomized Phase III Study of Gemcitabine Plus Herceptin Combinati... |
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 34580061 | 2021 | Article | Cancer research | ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor C... |
| 24295415 | 2013 | Article | Future oncology (London, Engla | Liposomal chemotherapeutics. |
| 28961673 | 2017 | Article | Retina (Philadelphia, Pa.) | Gemcitabine-Induced Retinopathy. |
| 14768404 | 2003 | Article | Oncology (Williston Park, N.Y. | Gemcitabine, anthracycline, and taxane combinations for advanced breast cancer. |
| 12057039 | 2002 | Article | Clinical breast cancer | Preclinical studies of gemcitabine and trastuzumab in breast and lung cancer cel... |
| 40779028 | 2025 | Article | Breast cancer research and tre | Carboplatin, gemcitabine, and mifepristone for advanced breast and recurrent/per... |
| 15685819 | 2004 | Article | Oncology (Williston Park, N.Y. | Gemcitabine and paclitaxel in metastatic breast cancer: a review. |
| 25398698 | 2015 | Article | Cancer chemotherapy and pharma | Docetaxel, gemcitabine and bevacizumab as salvage chemotherapy for HER-2-negativ... |
| 15685821 | 2004 | Article | Oncology (Williston Park, N.Y. | Gemcitabine and platinum-based chemotherapy in metastatic breast cancer. |
| 24824628 | 2015 | Article | International journal of cance | Cisplatin and gemcitabine as the first line therapy in metastatic triple negativ... |
| 24359601 | 2014 | Article | Acta oncologica (Stockholm, Sw | PAM50 breast cancer intrinsic subtypes and effect of gemcitabine in advanced bre... |
| 15685824 | 2004 | Article | Oncology (Williston Park, N.Y. | Gemcitabine in combination with trastuzumab and/or platinum salts in breast canc... |
| 12722022 | 2003 | Article | Seminars in oncology | Gemcitabine and trastuzumab in metastatic breast cancer. |
| 16020974 | 2005 | Article | Oncology | Weekly docetaxel and gemcitabine as first-line treatment for metastatic breast c... |
| 38262235 | 2024 | Article | Gynecologic oncology | A phase I study of Mirvetuximab Soravtansine and gemcitabine in patients with FR... |
| 15685820 | 2004 | Article | Oncology (Williston Park, N.Y. | Gemcitabine and docetaxel in metastatic breast cancer. |
| 17462169 | 2007 | Article | Health technology assessment ( | The clinical effectiveness and cost-effectiveness of gemcitabine for metastatic ... |
| 14754469 | 2004 | Article | Clinical breast cancer | Gemcitabine and trastuzumab combinations for patients with metastatic breast can... |
| 26372358 | 2016 | Article | Molecular oncology | Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer de... |
| 12449040 | 2002 | Article | Bulletin du cancer | [Gemcitabine and breast cancer]. |
2. rectum mucinous adenocarcinoma L3 99.77%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01643499 | PHASE1 | COMPLETED | 79 | A Genotype-guided Dosing Study of mFOLFIRINOX in Previously Untreated Patients W... |
3. colon mucinous adenocarcinoma L3 99.76%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01643499 | PHASE1 | COMPLETED | 79 | A Genotype-guided Dosing Study of mFOLFIRINOX in Previously Untreated Patients W... |
| NCT03210298 | N/A | UNKNOWN | 1000 | Multicenter, International Online Documentation of Indications and Results of Pr... |
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 26805374 | 2015 | Article | Gan to kagaku ryoho. Cancer & | [A Case of Invasive Intraductal Papillary Mucinous Carcinoma, Penetrating the St... |
| 28133201 | 2016 | Article | Gan to kagaku ryoho. Cancer & | [Long-Term Survival in Response to Multimodality Therapy in a Patient with Invas... |
| 16957443 | 2006 | Article | Skinmed | Sister Mary Joseph's nodule as a presenting sign of internal malignancy. |
4. endometrial mixed adenocarcinoma L4 99.76%
5. villoglandular endometrial endometrioid adenocarcinoma L5 99.76%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
6. endometrial mucinous adenocarcinoma L3 99.75%
臨床試驗（1 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01652794 | PHASE1 | COMPLETED | 12 | A Phase 1 Study of Carboplatin and Gemcitabine Chemotherapy and Stereotactic Bod... |
相關文獻（7 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 19473054 | 2009 | Article | Neoplasma | Gemcitabine and carboplatin treatment in patients with relapsing ovarian cancer. |
| 21436695 | 2011 | Article | International journal of gynec | Pegylated liposomal doxorubicin and gemcitabine in a fixed dose rate infusion fo... |
| 25374244 | 2014 | Article | Asian Pacific journal of cance | Efficacy of permanent iodine-125 seed implants and gemcitabine chemotherapy in p... |
| 23698798 | 2013 | Article | International journal of gynec | Feasibility of adjuvant chemotherapy after pelvic exenteration for gynecologic m... |
| 23296063 | 2013 | Article | Oncology | Improved survival trends in platinum-resistant patients with advanced ovarian, f... |
| 23886213 | 2013 | Article | Asian Pacific journal of cance | Phase II clinical study on the GEMOX regimen as second- line therapy for advance... |
| 23725151 | 2013 | Article | Asian Pacific journal of cance | Treatment outcomes of paclitaxel for refractory or recurrent epithelial ovarian ... |
7. cervical mucinous adenocarcinoma L3 99.75%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01652794 | PHASE1 | COMPLETED | 12 | A Phase 1 Study of Carboplatin and Gemcitabine Chemotherapy and Stereotactic Bod... |
| NCT04683939 | PHASE1, PHASE2 | TERMINATED | 13 | Phase I/IIa, First-in-human, Open-label, Dose Escalation Trial With Expansion Co... |
相關文獻（4 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35699889 | 2022 | Article | Clinical journal of gastroente | Genomic analysis of an aggressive case with metastatic intrahepatic mucinous cho... |
| 36938358 | 2023 | Article | Pathology oncology research : | Case report: Pathological and genetic features of pancreatic undifferentiated ca... |
| 26581412 | 2015 | Article | BMC gastroenterology | An indeterminate mucin-producing cystic neoplasm containing an undifferentiated ... |
| 30692448 | 2018 | Article | Gan to kagaku ryoho. Cancer & | [A Case of Long-Term Survival after Reoperation for Neck Lymph Node Metastasis O... |
8. gallbladder mucinous adenocarcinoma L3 99.75%
臨床試驗（2 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01643499 | PHASE1 | COMPLETED | 79 | A Genotype-guided Dosing Study of mFOLFIRINOX in Previously Untreated Patients W... |
| NCT03210298 | N/A | UNKNOWN | 1000 | Multicenter, International Online Documentation of Indications and Results of Pr... |
相關文獻（3 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 25731241 | 2014 | Article | Gan to kagaku ryoho. Cancer & | [A case of advanced gallbladder cancer with mediastinum lymph node metastasis su... |
| 40671744 | 2025 | Article | World journal of clinical case | Radiofrequency ablation of liver metastases in a patient with pancreatic cancer ... |
| 20527247 | 2010 | Article | European journal of gynaecolog | Ovarian metastasis following gallbladder carcinoma: a case report. |
9. rete ovarii adenocarcinoma L5 99.73%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
10. secretory uterine corpus endometrioid adenocarcinoma L5 99.73%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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