Dorzolamide
證據等級: L3 | 預測適應症: 10 個
## 藥師評估報告
Dorzolamide：從高眼壓症到原發性遺傳性青光眼
一句話總結
Dorzolamide 原本用於治療高眼壓症及廣角性青光眼。 TxGNN 模型預測它可能對**原發性遺傳性青光眼 (primary hereditary glaucoma)** 有效， 目前有 **1 個臨床試驗**和多項開角性青光眼研究支持這個方向。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 高眼壓症、廣角性青光眼 |
| 預測新適應症 | open-angle glaucoma、primary hereditary glaucoma、hypotrichosis simplex of the scalp、congenital hypotrichosis milia、alopecia、diffuse alopecia areata、glaucoma 1, open angle、open angle glaucoma、congestive heart failure、acute pulmonary heart disease |
| TxGNN 預測分數 | 99.99% |
| 證據等級 | L3 |
| 台灣上市 | 已上市 |
| 許可證數 | 多張 |
| 建議決策 | Proceed with Guardrails |
預測適應症詳細分析
1. primary hereditary glaucoma L3 99.99% 主要分析
為什麼這個預測合理？
Dorzolamide 是碳酸酐酶抑制劑，透過抑制眼內睫狀體的碳酸酐酶 II 型，
減少房水分泌，從而降低眼內壓。其在開角性青光眼中的療效已被證實，
而原發性遺傳性青光眼雖然病因涉及基因突變，但眼壓升高仍是主要致病機轉，
因此降眼壓治療在機轉上具有合理性。
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此預測基於藥物的作用機轉，與現有臨床證據方向一致。
臨床試驗
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT01527682 | PHASE2 | COMPLETED | 37 | Efficacy and Safety of Prostaglandin Analogue and Carbonic Anhydrase Inhibitor f... |
2. hypotrichosis simplex of the scalp L5 99.95%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
3. congenital hypotrichosis milia L5 99.94%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. alopecia L4 99.90%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 15091328 | 2004 | Article | Veterinary ophthalmology | Uveodermatologic syndrome in a Brazilian Fila dog. |
5. diffuse alopecia areata L5 99.90%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
6. glaucoma 1, open angle L1 99.75%
臨床試驗（41 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00333125 | PHASE3 | COMPLETED | 319 | A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension |
| NCT01887223 | PHASE2 | COMPLETED | 40 | Early Transconjunctival Needling Revision With 5-fluorouracil Versus Medical Tre... |
| NCT01896180 | PHASE2 | COMPLETED | 63 | A Pilot, Single-Masked Study to Compare the Safety and Efficacy of ALZ-1101 (Lat... |
| NCT00314171 | PHASE3 | COMPLETED | 437 | A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertensio... |
| NCT00822081 | PHASE4 | COMPLETED | 140 | Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timo... |
| NCT00546286 | PHASE3 | COMPLETED | 170 | A 12 Week, Open-Label, Study to Evaluate the Effectiveness of Dorzolamide-Timolo... |
| NCT03257813 | PHASE3 | COMPLETED | 60 | Clinical Study to Evaluate the Non-inferiority of PRO-122 an Ophthlamic Solution... |
| NCT00397241 | PHASE4 | COMPLETED | 33 | 24-hour IOP With DTFC and LTFC Monotherapies and the Adjunctive Therapy of DTFC ... |
| NCT00273455 | PHASE4 | COMPLETED | 34 | Lumigan Versus Cosopt |
| NCT00767481 | PHASE3 | TERMINATED | 6 | 1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT |
| NCT03193333 | PHASE3 | TERMINATED | 51 | A Non-inferiority in the Intraocular Pressure Decrease of the Preservative-free ... |
| NCT00991822 | PHASE2, PHASE3 | COMPLETED | 160 | A Double-masked Comparison of the Effect of Dorzolamide and Timolol on Optic Dis... |
| NCT00761995 | PHASE4 | COMPLETED | 200 | Safety and Efficacy of Brinzolamide Dosed TID With Dorzolamide Dosed TID in Redu... |
| NCT00576342 | PHASE3 | COMPLETED | 129 | A Single Dose Patient Preference Study Comparison in Patients With Open-Angle Gl... |
| NCT01471158 | PHASE4 | COMPLETED | 120 | Patient Preference Comparison of AZARGA Versus COSOPT After Single Doses in Pati... |
| NCT00957190 | PHASE4 | COMPLETED | 25 | Change in Optic Nerve Head Blood Flow,Optic Nerve Topography and Diurnal Fluctua... |
| NCT05973305 | PHASE3 | COMPLETED | 118 | A Randomized, Open-label, Controlled, Comparative Study of Efficacy and Safety o... |
| NCT06883123 | PHASE4 | RECRUITING | 70 | Efficacy and Tolerability of Simbrinza and Rocklatan vs. Cosopt |
| NCT02802137 | PHASE4 | COMPLETED | 43 | 24-hour Efficacy and Ocular Surface Health With PF Tafluprost and Combined Thera... |
| NCT00824824 | NA | COMPLETED | 21 | Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary O... |
| NCT05973318 | PHASE3 | COMPLETED | 110 | An Open-label, Randomized, Controlled, Comparative Efficacy and Safety Study of ... |
| NCT02325518 | PHASE4 | COMPLETED | 218 | The Efficacy and Safety of Brinzolamide 1%/Timolol 0.5% Fixed Combination Versus... |
| NCT06369077 | PHASE4 | TERMINATED | 36 | Cross-over Comparison of Latanoprost QOD With Dor-tim QAM to Tim-brim-dor-bim(At... |
| NCT02053298 | PHASE4 | COMPLETED | 30 | Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients |
| NCT00822055 | PHASE4 | COMPLETED | 140 | Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timo... |
| NCT03966560 | PHASE4 | COMPLETED | 96 | Choroidal Thickness and Its Correlations With Ocular Parameters in Cases With Pr... |
| NCT00273442 | PHASE4 | COMPLETED | 60 | Assessing Cosopt Switch Patients |
| NCT03966365 | PHASE1 | COMPLETED | 24 | Phase I Clinical Study, to Evaluate the Safety and Tolerability of the Preservat... |
| NCT04673604 | NA | COMPLETED | 42 | Changing From Preserved, to Preservative-free Cyclosporine 0.1% Enhanced Triple ... |
| NCT01340014 | PHASE4 | COMPLETED | 112 | Patient Preference Comparison of AZARGA Versus COSOPT in Patients With Open-Angl... |
| NCT06177678 | PHASE2 | UNKNOWN | 60 | A Randomized, Open-label, Active-controlled, Phase 2a Clinical Trial to Evaluate... |
| NCT04702789 | PHASE4 | TERMINATED | 28 | Phase IV Clinical Study to Compare the Efficacy of the Krytantek Ofteno PF® Plus... |
| NCT00815373 | NA | WITHDRAWN | 0 | A Comparative Analysis of the Effects of Cosopt® Versus Xalacom® on Ocular Hemod... |
| NCT01062971 | PHASE2 | COMPLETED | 124 | Comparative Clinical Study of The Safety And Efficacy of A New Fixed-Combination... |
| NCT00108017 | PHASE3 | COMPLETED | 330 | Randomized, Multicenter, Dbl-Masked, Parallel Study Evaluating the 24 Hr. Diurna... |
| NCT01145898 | N/A | COMPLETED | 56 | Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Pros... |
| NCT00471068 | PHASE4 | TERMINATED | 46 | Study of Travatan and Cosopt in Primary Open-Angle Glaucoma or Ocular Hypertensi... |
| NCT00972257 | PHASE4 | COMPLETED | 64 | Quality of 24-hour Intraocular Pressure Control Obtained With Dorzolamide/Timolo... |
| NCT00878917 | PHASE3 | COMPLETED | 32 | Randomized, Double-Masked, Active Controlled, Crossover Phase III Equivalence St... |
| NCT00273481 | PHASE4 | COMPLETED | 33 | Cosopt Versus Xalacom |
| NCT00675207 | PHASE4 | COMPLETED | 120 | Comparison of Brimonidine 0.15% Purite, Dorzolamide 2%, and Brinzolamide 1% as A... |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 26526633 | 2016 | Article | Ophthalmology | Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glauc... |
| 39569785 | 2024 | Article | Vestnik oftalmologii | [Efficacy and safety of the fixed combination of dorzolamide/timolol (Dorzotimol... |
| 37425383 | 2023 | Article | The Malaysian journal of medic | Comparing the Effectiveness and Adherence between Fixed and Non-Fixed Dorzolamid... |
| 39677168 | 2024 | Article | Cureus | Efficacy and Safety of a Fixed-Dose Combination of Brinzolamide 1%/Timolol 0.5% ... |
| 34447609 | 2021 | Article | Journal of drug assessment | Efficacy and safety of timolol-dorzolamide fixed-combination three times a day v... |
| 27913991 | 2017 | Article | Advances in therapy | 24-Hour Efficacy and Ocular Surface Health with Preservative-Free Tafluprost Alo... |
| 17943780 | 2007 | Article | The Cochrane database of syste | Medical interventions for primary open angle glaucoma and ocular hypertension. |
| 22207522 | 2011 | Article | International ophthalmology | Comparison of fixed combinations of dorzolamide/timolol and brimonidine/timolol ... |
| 33397657 | 2022 | Article | The British journal of ophthal | Short-term efficacy of latanoprostene bunod for the treatment of open-angle glau... |
| 16519552 | 2006 | Article | PharmacoEconomics | Bimatoprost: a pharmacoeconomic review of its use in open-angle glaucoma and ocu... |
| 11200308 | 2000 | Article | Drugs & aging | Topical dorzolamide 2%/timolol 0.5%: a review of its use in the treatment of ope... |
| 37164404 | 2023 | Article | Klinische Monatsblatter fur Au | Primary Open-Angle Glaucoma Progression in Glaucoma Patients with Unchanged Topi... |
| 18364402 | 2008 | Article | The Annals of pharmacotherapy | Effectiveness and safety of dorzolamide-timolol alone or combined with latanopro... |
| 16968583 | 2006 | Article | Current medical research and o | Comparison of the efficacy and safety of travoprost with a fixed-combination of ... |
| 32106236 | 2020 | Article | PloS one | The efficacy of the fixed combination of latanoprost and timolol versus other fi... |
| 20019759 | 2010 | Article | Eye (London, England) | Efficacy and safety of fixed combinations of latanoprost/timolol and dorzolamide... |
| 19348600 | 2009 | Article | Journal of ocular pharmacology | A comparison of the long-term effects of dorzolamide 2% and brinzolamide 1%, eac... |
| 10872922 | 2000 | Article | Journal of ocular pharmacology | Comparison of the efficacy and safety of latanoprost 0.005% compared to brimonid... |
| 20558428 | 2010 | Article | The British journal of ophthal | The additive effect of dorzolamide hydrochloride (Trusopt) and a morning dose of... |
| 18640468 | 2008 | Article | Clinical therapeutics | Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure,... |
7. open angle glaucoma L1 99.70%
臨床試驗（50 項）
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00333125 | PHASE3 | COMPLETED | 319 | A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension |
| NCT01887223 | PHASE2 | COMPLETED | 40 | Early Transconjunctival Needling Revision With 5-fluorouracil Versus Medical Tre... |
| NCT01896180 | PHASE2 | COMPLETED | 63 | A Pilot, Single-Masked Study to Compare the Safety and Efficacy of ALZ-1101 (Lat... |
| NCT00314171 | PHASE3 | COMPLETED | 437 | A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertensio... |
| NCT00822081 | PHASE4 | COMPLETED | 140 | Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timo... |
| NCT00546286 | PHASE3 | COMPLETED | 170 | A 12 Week, Open-Label, Study to Evaluate the Effectiveness of Dorzolamide-Timolo... |
| NCT03257813 | PHASE3 | COMPLETED | 60 | Clinical Study to Evaluate the Non-inferiority of PRO-122 an Ophthlamic Solution... |
| NCT00397241 | PHASE4 | COMPLETED | 33 | 24-hour IOP With DTFC and LTFC Monotherapies and the Adjunctive Therapy of DTFC ... |
| NCT00273455 | PHASE4 | COMPLETED | 34 | Lumigan Versus Cosopt |
| NCT00767481 | PHASE3 | TERMINATED | 6 | 1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT |
| NCT03193333 | PHASE3 | TERMINATED | 51 | A Non-inferiority in the Intraocular Pressure Decrease of the Preservative-free ... |
| NCT05857267 | PHASE4 | COMPLETED | 84 | Phase IV, Multicenter, Double-blind, Randomized, Controlled, Parallel-group, Tri... |
| NCT00991822 | PHASE2, PHASE3 | COMPLETED | 160 | A Double-masked Comparison of the Effect of Dorzolamide and Timolol on Optic Dis... |
| NCT00761995 | PHASE4 | COMPLETED | 200 | Safety and Efficacy of Brinzolamide Dosed TID With Dorzolamide Dosed TID in Redu... |
| NCT00576342 | PHASE3 | COMPLETED | 129 | A Single Dose Patient Preference Study Comparison in Patients With Open-Angle Gl... |
| NCT00621335 | N/A | COMPLETED | 64 | A 12- Week Investigator Masked, Parallel Comparison of Tolerability of Combigan ... |
| NCT01471158 | PHASE4 | COMPLETED | 120 | Patient Preference Comparison of AZARGA Versus COSOPT After Single Doses in Pati... |
| NCT00957190 | PHASE4 | COMPLETED | 25 | Change in Optic Nerve Head Blood Flow,Optic Nerve Topography and Diurnal Fluctua... |
| NCT01527682 | PHASE2 | COMPLETED | 37 | Efficacy and Safety of Prostaglandin Analogue and Carbonic Anhydrase Inhibitor f... |
| NCT01923714 | N/A | COMPLETED | 103 | Impact of a Tolerability Switch to Dorzolamide/Timolol Preservative-free Fixed C... |
| NCT05973305 | PHASE3 | COMPLETED | 118 | A Randomized, Open-label, Controlled, Comparative Study of Efficacy and Safety o... |
| NCT06883123 | PHASE4 | RECRUITING | 70 | Efficacy and Tolerability of Simbrinza and Rocklatan vs. Cosopt |
| NCT02802137 | PHASE4 | COMPLETED | 43 | 24-hour Efficacy and Ocular Surface Health With PF Tafluprost and Combined Thera... |
| NCT00824824 | NA | COMPLETED | 21 | Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary O... |
| NCT05973318 | PHASE3 | COMPLETED | 110 | An Open-label, Randomized, Controlled, Comparative Efficacy and Safety Study of ... |
| NCT04676126 | PHASE4 | WITHDRAWN | 0 | Augmented Macular Pigment Supplement and Pericentral Visual Function: a Randomiz... |
| NCT02325518 | PHASE4 | COMPLETED | 218 | The Efficacy and Safety of Brinzolamide 1%/Timolol 0.5% Fixed Combination Versus... |
| NCT06369077 | PHASE4 | TERMINATED | 36 | Cross-over Comparison of Latanoprost QOD With Dor-tim QAM to Tim-brim-dor-bim(At... |
| NCT02053298 | PHASE4 | COMPLETED | 30 | Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients |
| NCT00822055 | PHASE4 | COMPLETED | 140 | Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timo... |
| NCT03966560 | PHASE4 | COMPLETED | 96 | Choroidal Thickness and Its Correlations With Ocular Parameters in Cases With Pr... |
| NCT00273442 | PHASE4 | COMPLETED | 60 | Assessing Cosopt Switch Patients |
| NCT00545064 | PHASE4 | COMPLETED | 176 | A Multicenter, Open-Label Study To Evaluate The Tolerability Of Preservative Fre... |
| NCT03966365 | PHASE1 | COMPLETED | 24 | Phase I Clinical Study, to Evaluate the Safety and Tolerability of the Preservat... |
| NCT04673604 | NA | COMPLETED | 42 | Changing From Preserved, to Preservative-free Cyclosporine 0.1% Enhanced Triple ... |
| NCT01340014 | PHASE4 | COMPLETED | 112 | Patient Preference Comparison of AZARGA Versus COSOPT in Patients With Open-Angl... |
| NCT00440336 | NA | UNKNOWN | 30 | Comparison of Efficacy of Prostaglandin Analogues (Xalatan) and Aqueous Suppress... |
| NCT06177678 | PHASE2 | UNKNOWN | 60 | A Randomized, Open-label, Active-controlled, Phase 2a Clinical Trial to Evaluate... |
| NCT04702789 | PHASE4 | TERMINATED | 28 | Phase IV Clinical Study to Compare the Efficacy of the Krytantek Ofteno PF® Plus... |
| NCT00815373 | NA | WITHDRAWN | 0 | A Comparative Analysis of the Effects of Cosopt® Versus Xalacom® on Ocular Hemod... |
| NCT01062971 | PHASE2 | COMPLETED | 124 | Comparative Clinical Study of The Safety And Efficacy of A New Fixed-Combination... |
| NCT00108017 | PHASE3 | COMPLETED | 330 | Randomized, Multicenter, Dbl-Masked, Parallel Study Evaluating the 24 Hr. Diurna... |
| NCT01304264 | N/A | COMPLETED | 35 | Comparison of Intraocular Pressure, Blood Pressure, Ocular Perfusion and Blood F... |
| NCT01145898 | N/A | COMPLETED | 56 | Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Pros... |
| NCT00152932 | NA | UNKNOWN | 17 | Ocular Blood Flow Measured by HRF and CLBF in Newly Diagnosed and Early Glaucoma... |
| NCT00140049 | PHASE4 | COMPLETED | 238 | A 12-Week Randomized, Evaluator-Masked, Parallel-Group, Multinational, Multi-Cen... |
| NCT00471068 | PHASE4 | TERMINATED | 46 | Study of Travatan and Cosopt in Primary Open-Angle Glaucoma or Ocular Hypertensi... |
| NCT07335211 | PHASE3 | RECRUITING | 206 | A Multicenter, Randomized, Single-blind, Active Controlled, Phase III Clinical T... |
| NCT00972257 | PHASE4 | COMPLETED | 64 | Quality of 24-hour Intraocular Pressure Control Obtained With Dorzolamide/Timolo... |
| NCT00273429 | PHASE4 | COMPLETED | N/A | Cosopt Versus Xalatan |
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 26526633 | 2016 | Article | Ophthalmology | Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glauc... |
| 38985892 | 2024 | Article | Journal of cataract and refrac | Open-angle glaucoma and Fuchs dystrophy. |
| 39569785 | 2024 | Article | Vestnik oftalmologii | [Efficacy and safety of the fixed combination of dorzolamide/timolol (Dorzotimol... |
| 40261315 | 2025 | Article | The Medical letter on drugs an | Drugs for open-angle glaucoma. |
| 37425383 | 2023 | Article | The Malaysian journal of medic | Comparing the Effectiveness and Adherence between Fixed and Non-Fixed Dorzolamid... |
| 39677168 | 2024 | Article | Cureus | Efficacy and Safety of a Fixed-Dose Combination of Brinzolamide 1%/Timolol 0.5% ... |
| 33217844 | 2020 | Article | Medicine | Can dorzolamide/timolol-fixed combination effectively treat primary open-angle g... |
| 34447609 | 2021 | Article | Journal of drug assessment | Efficacy and safety of timolol-dorzolamide fixed-combination three times a day v... |
| 17943780 | 2007 | Article | The Cochrane database of syste | Medical interventions for primary open angle glaucoma and ocular hypertension. |
| 36453306 | 2022 | Article | Indian journal of ophthalmolog | Efficacy of dorzolamide in improving ocular blood flow in patients with open-ang... |
| 28956449 | 2018 | Article | Drug development and industria | Dorzolamide nanoliposome as a long action ophthalmic delivery system in open ang... |
| 33397657 | 2022 | Article | The British journal of ophthal | Short-term efficacy of latanoprostene bunod for the treatment of open-angle glau... |
| 19929032 | 2009 | Article | Drugs & aging | Bimatoprost: a review of its use in open-angle glaucoma and ocular hypertension. |
| 32637736 | 2020 | Article | American journal of ophthalmol | Netarsudil-associated epithelial keratopathy. |
| 27913991 | 2017 | Article | Advances in therapy | 24-Hour Efficacy and Ocular Surface Health with Preservative-Free Tafluprost Alo... |
| 32106236 | 2020 | Article | PloS one | The efficacy of the fixed combination of latanoprost and timolol versus other fi... |
| 16519552 | 2006 | Article | PharmacoEconomics | Bimatoprost: a pharmacoeconomic review of its use in open-angle glaucoma and ocu... |
| 11200308 | 2000 | Article | Drugs & aging | Topical dorzolamide 2%/timolol 0.5%: a review of its use in the treatment of ope... |
| 35415266 | 2022 | Article | BMJ open ophthalmology | Assessment of the readability and quality of online patient education materials ... |
| 12630335 | 2003 | Article | Drug and therapeutics bulletin | New topical drugs for open-angle glaucoma. |
8. congestive heart failure L4 99.61%
9. acute pulmonary heart disease L5 99.53%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
10. respiratory failure L4 99.27%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 16879567 | 2006 | Article | Acta ophthalmologica Scandinav | Optic nerve pH and PO2: the effects of carbonic anhydrase inhibition, and metabo... |
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
歡迎分享您對本報告的看法、補充資訊或提出問題。討論內容會同步到 GitHub Discussions。 需要 GitHub 帳號才能留言。