Aluminum Oxide
證據等級: L4 | 預測適應症: 10 個
## 藥師評估報告
Aluminum oxide：從胃酸過多到類風濕性關節炎
一句話總結
Aluminum oxide 原本用於緩解胃部不適或灼熱感等胃酸過多症狀。 TxGNN 模型預測它可能對**類風濕性關節炎 (Rheumatoid Arthritis)** 有效， 目前有 **1 個臨床試驗**和 **1 篇文獻**支持這個方向，但證據主要來自於材料科學研究。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 緩解胃部不適或灼熱感、或經診斷為胃及十二指腸潰瘍、胃炎、食道炎所伴隨之胃酸過多。 |
| 預測新適應症 | 類風濕性關節炎 (Rheumatoid Arthritis) |
| TxGNN 預測分數 | 99.98% |
| 證據等級 | L4 |
| 台灣上市 | ✓ 已上市 |
| 許可證數 | 18 張 |
| 建議決策 | Hold |
預測適應症詳細分析
1. rheumatoid arthritis L3 99.98% 主要分析
為什麼這個預測合理？
目前缺乏詳細的作用機轉資料。根據已知資訊，Aluminum oxide 是一種內服凝膠劑，主要用於緩解胃酸過多相關症狀。
由於類風濕性關節炎涉及免疫系統，現有劑型無法達到全身性療效，需開發新劑型以評估其在類風濕性關節炎中的潛力。
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此預測基於藥物的作用機轉，與現有臨床證據方向一致。
臨床試驗
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00764530 | NA | COMPLETED | 342 | Keramos Ceramic/Ceramic Total Hip System |
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 35819069 | 2022 | Article | ACS biomaterials science & eng | NIR-PTT/ROS-Scavenging/Oxygen-Enriched Synergetic Therapy for Rheumatoid Arthrit... |
| 2409750 | 1985 | Article | Acta medica Scandinavica | Plasma total prekallikrein/kallikrein activity in rheumatoid arthritis with and ... |
| 32342135 | 2020 | Article | Naunyn-Schmiedeberg's archives | Anti-arthritic and anti- inflammatory effects of extract and fractions of Malva ... |
| 4950006 | 1970 | Article | Progress in clinical pathology | Antibodies to tissues. |
| 35549591 | 2022 | Article | Journal of drug targeting | ZIF-8 nanoparticles coated with macrophage-derived microvesicles for sustained, ... |
| 32707885 | 2020 | Article | Molecules (Basel, Switzerland) | Benzylideneacetophenone Derivative Alleviates Arthritic Symptoms via Modulation ... |
| 7258747 | 1981 | Article | Annals of allergy | Evaluation of lymphocyte populations and their mitogenic activity in relation to... |
| 30062938 | 2018 | Article | The bone & joint journal | Mid-term results of alumina ceramic unlinked total elbow arthroplasty with cemen... |
| 4365175 | 1974 | Article | Polish journal of pharmacology | Prostaglandins and inflammation. |
| 28958658 | 2018 | Article | The Journal of arthroplasty | A Minimum Ten Years of Follow-Up of Alumina Head on Delta Liner Total Hip Arthro... |
| 2838005 | 1988 | Article | Archives of pathology & labora | Diseases associated with exposure to silica and nonfibrous silicate minerals. Si... |
| 12211691 | 2002 | Article | The Journal of bone and joint | Effects of alumina and zirconium dioxide particles on arachidonic acid metabolis... |
| 24197059 | 2014 | Article | Journal of orthopaedic science | A 5-22-year follow-up study of stemmed alumina ceramic total elbow arthroplastie... |
| 28238009 | 2017 | Article | Acta medica Okayama | Results of Total Elbow Arthroplasty with Cementless Implantation of an Alumina C... |
| 13922480 | 1962 | Article | Reumatismo | [The bentonite flocculation test in rheumatoid arthritis and in other morbid con... |
| 5683163 | 1968 | Article | Experientia | Hageman factor (factor XII) activity in synovial fluid of rheumatoid arthritis p... |
| 6987312 | 1980 | Article | Journal of immunological metho | Quantitative determination of rheumatoid factor by an enzyme-labeled immunoassay... |
| 32097698 | 2020 | Article | Journal of ethnopharmacology | Effect of phenolic compounds from Oenothera rosea on the kaolin-carrageenan indu... |
| 25260980 | 2014 | Article | Arthritis research & therapy | Tapping into the endocannabinoid system to ameliorate acute inflammatory flares ... |
| 13626976 | 1959 | Article | The American journal of the me | A comparison of the latex fixation-whole serum, latex fixation-euglobulin fracti... |
2. brachydactyly-syndactyly syndrome L5 99.96%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
3. colobomatous microphthalmia-rhizomelic dysplasia syndrome L5 99.96%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. heparin cofactor 2 deficiency L4 99.90%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 3838315 | 1985 | Article | The Journal of biological chem | The protease specificity of heparin cofactor II. Inhibition of thrombin generate... |
5. hemoglobinopathy L4 99.90%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 37951856 | 2023 | Article | BMC oral health | Effects of different removal methods of excess resin adhesive on the microleakag... |
6. factor 5 excess with spontaneous thrombosis L5 99.90%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
7. antithrombin deficiency type 2 L5 99.89%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
8. thrombotic disease L4 99.87%
相關文獻（20 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 39580078 | 2025 | Article | Journal of controlled release | Macrophage membrane-encapsulated miRNA nanodelivery system for the treatment of ... |
| 38396728 | 2024 | Article | International journal of molec | Thrombelastography and Conventional Coagulation Markers in Chronic Obstructive P... |
| 23429252 | 2013 | Article | Blood coagulation & fibrinolys | C-reactive protein and fibrin clot strength measured by thrombelastography after... |
| 9564904 | 1998 | Article | The Annals of thoracic surgery | Pathogenesis of systemic air embolism during bronchoscopic Nd:YAG laser operatio... |
| 20154537 | 2010 | Article | The Journal of trauma | Safety evaluation of new hemostatic agents, smectite granules, and kaolin-coated... |
| 8850470 | 1996 | Article | Lasers in surgery and medicine | Photodynamic therapy (PDT) of the ciliary body with silicon naphthalocyanine (SI... |
| 9603285 | 1998 | Article | Lasers in surgery and medicine | Acute results, complications, and effect of lesion characteristics on outcome wi... |
| 10064002 | 1999 | Article | Thrombosis and haemostasis | dRVVT is more sensitive than KCT or TTI for detecting lupus anticoagulant activi... |
| 1466271 | 1992 | Article | Agents and actions. Supplement | A finding of highly selective synthetic inhibitor of plasma kallikrein; its acti... |
| 23944273 | 2013 | Article | Veterinary clinical pathology | Endogenous fibrinolytic potential in tissue-plasminogen activator-modified throm... |
| 12842992 | 2003 | Article | Blood | The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of hi... |
| 698402 | 1978 | Article | Blood | Coupled amidolytic assay for factor VII: its use with a clotting assay to determ... |
| 9490682 | 1998 | Article | Blood | Differential effects of anti-beta2-glycoprotein I and antiprothrombin antibodies... |
| 7419960 | 1980 | Article | The Journal of laboratory and | Rapid fibrinolysis, augmented Hageman factor (factor XII) titers, and decreased ... |
| 6803570 | 1982 | Article | American journal of clinical p | Prekallikrein inhibition associated with the lupus anticoagulant: a mechanism of... |
| 4236824 | 1968 | Article | Thrombosis et diathesis haemor | Release of platelet factor 4 in vivo during intravascular coagulation and in thr... |
| 128018 | 1975 | Article | Physiologia Bohemoslovaca | A quantitative model of venous stasis thrombosis in rats. |
| 6741145 | 1984 | Article | Wiener klinische Wochenschrift | [The PTFE plastic prosthesis as an arterial replacement: experiences over a 5-ye... |
| 1226814 | 1975 | Article | Zeitschrift fur Allgemeinmediz | [Therapy of chronic persistent ulcus cruris with phlebostatic edema in chronic p... |
| 4460211 | 1974 | Article | Revue roumaine de medecine (19 | Clotting disturbances as thrombosis risk factors. Significance and diagnostic va... |
9. beta-thalassemia with other manifestations L5 99.85%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
10. hemolytic anemia due to glucophosphate isomerase deficiency L5 99.84%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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