RTI International (RTI Wellmine) 聯繫信件

目標：探討罕見疾病老藥新用合作 優先級：高（Phase 1） 聯繫方式：https://wellmine.rti.org

信件內容

Subject: Collaboration Inquiry: Drug Repurposing for Rare Diseases - TwTxGNN x RTI Wellmine

Dear RTI Wellmine Team,

I am writing to explore a potential collaboration between TwTxGNN and RTI Wellmine for rare disease drug repurposing research.

About TwTxGNN

TwTxGNN is an open-source SMART on FHIR application that provides AI-powered drug repurposing predictions based on Harvard's TxGNN knowledge graph model published in Nature Medicine (2023).

Key Statistics:

189 drugs with validated repurposing predictions
1,268 predicted new indications
101 drugs with rare disease predictions
101 rare disease indications covered
Five-level evidence classification (L1-L5)
FHIR R4 compatible API

Website: https://twtxgnn.yao.care/ GitHub: https://github.com/yao-care/TwTxGNN

Proposed Collaboration

We believe TwTxGNN's drug repurposing predictions can complement RTI Wellmine's patient data collection platform in the following ways:

API Integration
- Integrate TwTxGNN FHIR API into the Wellmine platform
- Enable rare disease patients to view potential repurposed drug candidates for their conditions
- Provide evidence levels and supporting clinical trial references
Research Validation
- Leverage Wellmine's patient-reported outcomes to validate AI predictions
- Identify high-priority candidates based on patient interest and need
- Facilitate research collaborations with academic institutions
Data Enrichment
- TwTxGNN provides drug predictions with ClinicalTrials.gov and PubMed evidence
- Wellmine provides real-world patient data and feedback
- Combined data can accelerate rare disease treatment discovery

Technical Specifications

Item	TwTxGNN Capability
FHIR Version	R4 (4.0.1)
API Format	Static JSON (FHIR resources)
Endpoints	`/fhir/MedicationKnowledge/{drug}.json`, `/fhir/ClinicalUseDefinition/{prediction}.json`
Authentication	None required (public data)

Next Steps

Would you be available for a brief call to discuss this opportunity? We would be happy to:

Provide a technical demonstration of TwTxGNN
Share our rare disease drug prediction dataset
Discuss API integration requirements
Explore research collaboration frameworks

We believe this collaboration could accelerate rare disease treatment discovery while leveraging Wellmine's unique patient data collection capabilities.

Thank you for your consideration. We look forward to hearing from you.

Best regards,

TwTxGNN Team https://twtxgnn.yao.care/

附件清單

準備發送時，請附上以下資料：

英文版專案簡介：project-intro-en.md
FHIR API 規格：api-spec.md
罕見疾病藥物預測統計（見下方）

罕見疾病相關統計

根據 TwTxGNN 資料庫（search-index.json）：

指標	數值
涉及罕見疾病的藥物數	101
罕見疾病預測適應症數	101
L1-L2 高證據預測	7
L3-L4 中證據預測	25
L5 模型預測	159

分類關鍵字：syndrome, deficiency, inherited, congenital, genetic

待辦事項

建立日期：2026-03-01