Aditus (Lupus Advisor) 聯繫信件

目標：探討狼瘡照護整合 優先級：中（Phase 3） 聯繫方式：

開發商: Point-of-Care Partners (POCP)
建議聯繫: Brian Bamberger (General Manager, Life Sciences) - Brian.Bamberger@pocp.com
備選: Amy Johnson (VP Client Services) - Amy.Johnson@pocp.com
電話: (877) 312-7627
網站: https://www.lupusadvisor.com/

信件內容

Subject: Integration Inquiry: AI Drug Repurposing for Systemic Lupus Erythematosus Care

Dear Aditus Team,

I am exploring a potential integration between TwTxGNN and Lupus Advisor to enhance clinical decision support for systemic lupus erythematosus (SLE) patients.

About TwTxGNN

TwTxGNN is a SMART on FHIR application that provides AI-powered drug repurposing predictions using Harvard's TxGNN knowledge graph model.

Autoimmune Disease Focus:

17 drugs with autoimmune disease predictions
16 predicted indications
Coverage includes lupus-related conditions
Validated against ClinicalTrials.gov and PubMed

Technical Specs:

FHIR R4 compatible
Static FHIR API available
Open source (MIT license)

Website: https://twtxgnn.yao.care/ GitHub: https://github.com/yao-care/TwTxGNN

Proposed Integration

Lupus Advisor's automated EHR assistance workflow could be enhanced with drug repurposing insights:

Treatment Optimization
- When guideline-recommended treatments show inadequate response
- Display AI-predicted alternative candidates with evidence levels
- Link to supporting clinical trial data
Refractory Case Support
- For patients not responding to standard therapies
- Provide research-backed alternatives for physician consideration
- Include evidence classification (L1-L5)
Clinical Trial Matching
- Connect patients with relevant ongoing trials
- Integrate ClinicalTrials.gov data for predicted indications

Technical Integration

Since both applications use FHIR R4, integration should be straightforward:

Integration Point	Method
Data Exchange	FHIR MedicationKnowledge resources
API Access	Static JSON endpoints
Trigger	Disease activity / treatment response indicators

Example API Call:

GET https://twtxgnn.yao.care/fhir/MedicationKnowledge/hydroxychloroquine.json

Benefits for Lupus Advisor Users

Benefit	Description
Expanded Options	AI-identified candidates beyond standard guidelines
Evidence-Based	Each prediction validated against clinical data
Safety Integrated	DDI checking for 222,391 drug pairs
Trial Links	Direct connection to relevant clinical trials

Next Steps

Would you be open to:

A brief technical call to discuss integration options?
A pilot study with select healthcare institutions?
Reviewing our lupus-related drug predictions?

We believe this integration could provide valuable additional insights for lupus patients, particularly those with refractory disease.

Best regards,

TwTxGNN Team https://twtxgnn.yao.care/

附件清單

英文版專案簡介：project-intro-en.md
FHIR API 規格：api-spec.md
自體免疫疾病藥物預測清單

背景資料

Aditus / Lupus Advisor

狼瘡照護自動化 EHR 輔助平台
SMART on FHIR R4 相容
符合 ACR/EULAR 指引

狼瘡相關適應症

TwTxGNN 中可能相關的適應症關鍵字：

lupus
systemic lupus erythematosus
autoimmune
inflammatory

待辦事項

建立日期：2026-03-01