Oteracil
證據等級: L2 | 預測適應症: 10 個
## 藥師評估報告
Oteracil：從胃癌到大腸腫瘤
一句話總結
Oteracil 是 S-1 複方的成分之一，原本用於胃癌治療。 TxGNN 模型預測它可能對**大腸腫瘤 (Colonic Neoplasm)** 有效， 目前有 **7 個臨床試驗**和 **10 篇文獻**支持這個方向。
快速總覽
| 項目 | 內容 |
|---|---|
| 原適應症 | 胃癌用藥。 |
| 預測新適應症 | colonic neoplasm、cecum villous adenoma、cecum neuroendocrine tumor G1、lipoma of colon、cecal disease、rectosigmoid junction neoplasm、benign neoplasm of cecum、colonic lymphangioma、colon leiomyoma、cavernous hemangioma of colon |
| TxGNN 預測分數 | 99.99% |
| 證據等級 | L2 |
| 台灣上市 | ✓ 已上市 |
| 許可證數 | 8 張 |
| 建議決策 | Proceed with Guardrails |
預測適應症詳細分析
1. colonic neoplasm L1 99.99% 主要分析
為什麼這個預測合理？
目前缺乏詳細的作用機轉資料。根據已知資訊，Oteracil 是 S-1 複方的一部分，其成分在胃癌中的療效已被證實，機轉上可能適用於大腸腫瘤。S-1 包含的 tegafur 是 5-FU 的前驅藥，已知能夠抑制快速分裂的癌細胞中的 DNA 合成，這在大腸腫瘤中可能有效。
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此預測基於藥物的作用機轉，與現有臨床證據方向一致。
臨床試驗
| 試驗編號 | 階段 | 狀態 | 人數 | 主要發現 |
|---|---|---|---|---|
| NCT00524706 | PHASE1, PHASE2 | UNKNOWN | 42 | Phase I/II Study of S-1, Oral Leucovorin, and Oxaliplatin Combination Therapy (S... |
| NCT02618356 | PHASE2 | UNKNOWN | 82 | A Phase II Clinical Study of Combined Use of Raltitrexed and S-1 as Treatment fo... |
| NCT00974389 | PHASE2 | UNKNOWN | 40 | Phase II Study of Combination Chemotherapy With S-1 Plus Avastin in Unresectable... |
| NCT01918852 | PHASE3 | COMPLETED | 161 | S1 Versus Capecitabine in the First Line Treatment of Metastatic Colorectal Canc... |
| NCT03448549 | PHASE3 | UNKNOWN | 1191 | A Prospective Randomized Controlled Trial to Compare Oxaliplatin Combined With S... |
| NCT06255379 | PHASE2 | NOT_YET_RECRUITING | 52 | An Open, Single-arm, Multicenter, Prospective Phase II Study of Fuquinitinib Com... |
| NCT00660894 | PHASE3 | COMPLETED | 1535 | Randomized Phase III Study of UFT+Leucovorin vs. TS-1 as Adjuvant Treatment for ... |
| NCT02216149 | PHASE2 | TERMINATED | 20 | Effects of S-1 and Capecitabine in Combination With Oxaliplatin on the Coronary ... |
相關文獻
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 25209093 | 2014 | Article | Clinical colorectal cancer | Adaptation of international guidelines for metastatic colorectal cancer: an asia... |
| 28414195 | 2017 | Article | European journal of dermatolog | Tegafur/gimeracil/oteracil (TS-1)-induced erythroderma with an extensive mucosal... |
| 20500514 | 2010 | Article | Cancer science | Characterization of a novel lymph node metastasis model from human colonic cance... |
| 32936722 | 2021 | Article | Journal of oncology pharmacy p | Hypertriglyceridemia induced by S-1: A novel case report and review of the liter... |
| 26805106 | 2015 | Article | Gan to kagaku ryoho. Cancer & | [A Successful Case of Treatment of Colonic Metastasis and Peritoneal Recurrence ... |
| 17496461 | 2007 | Article | Gan to kagaku ryoho. Cancer & | [Adjuvant chemotherapy for colorectal cancer in Japan-current state and problem ... |
| 31917122 | 2020 | Article | Clinical colorectal cancer | S-1 and Oxaliplatin Versus Tegafur-uracil and Leucovorin as Postoperative Adjuva... |
| 29491068 | 2018 | Article | Anticancer research | Pre-exposure to Fluorouracil Increased Trifluridine Incorporation and Enhanced i... |
| 26976971 | 2016 | Article | Anticancer research | Genome-wide DNA Copy-number Analysis in ACTS-CC Trial of Adjuvant Chemotherapy f... |
| 12833857 | 2003 | Article | Nihon Shokakibyo Gakkai zasshi | [Recent advances in chemotherapy for digestive cancers with special references t... |
| 25132036 | 2014 | Article | Gan to kagaku ryoho. Cancer & | [A case of disseminated carcinomatosis of the bone marrow with disseminated intr... |
| 27056996 | 2016 | Article | Annals of oncology : official | A randomized phase III trial comparing S-1 versus UFT as adjuvant chemotherapy f... |
| 40840913 | 2025 | Article | Gan to kagaku ryoho. Cancer & | [A Case of Long-Term Complete Remission with Solitary Metastasis Following Surge... |
| 26036466 | 2015 | Article | BMC cancer | Randomized phase II study of S-1 dosing schedule for resected colorectal cancer. |
| 32189156 | 2020 | Article | International journal of clini | Efficacy and feasibility of S-1 plus oxaliplatin (C-SOX) for treating patients w... |
| 24942277 | 2014 | Article | Annals of oncology : official | S-1 as adjuvant chemotherapy for stage III colon cancer: a randomized phase III ... |
| 23320901 | 2013 | Article | Trials | Optimal schedule of adjuvant chemotherapy with S-1 for stage III colon cancer: s... |
| 21875473 | 2011 | Article | Zhonghua zhong liu za zhi [Chi | [Efficacy and side effects of combination therapy of oxaliplatin and S-1 for col... |
| 10897209 | 2000 | Article | Gan to kagaku ryoho. Cancer & | [Conceptual changes in cancer chemotherapy--biochemical modulation of 5-FU]. |
| 26045119 | 2015 | Article | Tumori | Long-term survival in metastasized leiomyosarcoma: a case report and review of t... |
2. cecum villous adenoma L5 99.98%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
3. cecum neuroendocrine tumor G1 L5 99.98%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
4. lipoma of colon L5 99.98%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
5. cecal disease L4 99.98%
相關文獻（9 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 39024793 | 2024 | Article | Journal of pharmaceutical and | Amelioration of hyperuricemia by cordycepin and Cordyceps militaris aqueous extr... |
| 25918266 | 2015 | Article | Hinyokika kiyo. Acta urologica | [Vesico-appendiceal fistula caused by appendiceal cancer: a case report]. |
| 22333648 | 2012 | Article | Gan to kagaku ryoho. Cancer & | [A case of cecal cancer with abdominal wall abscess]. |
| 30692384 | 2018 | Article | Gan to kagaku ryoho. Cancer & | [A Case of Complete Response to Computed Tomography-Guided Celiac Plexus Neuroly... |
| 24018598 | 2013 | Article | JOP : Journal of the pancreas | Synchronous triple cancers of the pancreas, stomach, and cecum treated with S-1 ... |
| 17431353 | 2007 | Article | Gan to kagaku ryoho. Cancer & | [Successful low-dose TS-1 administration in an elderly colon cancer patient with... |
| 16612166 | 2006 | Article | Gan to kagaku ryoho. Cancer & | [A case of advanced colon cancer with metastases to both para-aortic lymph nodes... |
| 29362308 | 2018 | Article | Gan to kagaku ryoho. Cancer & | [An Elderly Patient with Metastatic Colon Cancer Achieved Long-Term Survival Fol... |
| 24189822 | 2013 | Article | Nihon Shokakibyo Gakkai zasshi | [A case of advanced signet ring cell carcinoma of the appendix that responded to... |
6. rectosigmoid junction neoplasm L5 99.98%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
7. benign neoplasm of cecum L4 99.98%
相關文獻（6 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 10997934 | 2000 | Article | Drug metabolism and dispositio | Tissue distribution and biotransformation of potassium oxonate after oral admini... |
| 24018598 | 2013 | Article | JOP : Journal of the pancreas | Synchronous triple cancers of the pancreas, stomach, and cecum treated with S-1 ... |
| 22202431 | 2011 | Article | Gan to kagaku ryoho. Cancer & | [A long-term survival case in advanced mucinous cystadenocarcinoma of the append... |
| 22333648 | 2012 | Article | Gan to kagaku ryoho. Cancer & | [A case of cecal cancer with abdominal wall abscess]. |
| 26199249 | 2015 | Article | Gan to kagaku ryoho. Cancer & | [Clinical Response of Metastatic Colon Cancer to Chemotherapy with S-1 and Oxali... |
| 17431353 | 2007 | Article | Gan to kagaku ryoho. Cancer & | [Successful low-dose TS-1 administration in an elderly colon cancer patient with... |
8. colonic lymphangioma L5 99.98%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
9. colon leiomyoma L4 99.98%
相關文獻（1 篇）
| PMID | 年份 | 類型 | 期刊 | 主要發現 |
|---|---|---|---|---|
| 40322391 | 2025 | Article | Cureus | Torsion of Metastatic Ovarian Tumor Originating From Sigmoid Colon Cancer. |
10. cavernous hemangioma of colon L5 99.98%
目前尚無針對此適應症的專門臨床研究。此為 TxGNN 模型預測結果，需進一步驗證。
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免責聲明
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
本報告僅供學術研究參考，不構成醫療建議。藥物使用請遵循醫師指示，切勿自行調整用藥。任何老藥新用決策需經過完整的臨床驗證與法規審查。
最後審核：2026-02-20 | 審核者：TwTxGNN Research Team
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